Results 1 to 10 of about 428,092 (271)
Hepcidin knockout exacerbates hindlimb unloading-induced bone loss in mice through inhibiting osteoblastic differentiation. [PDF]
BMC Musculoskelet DisordBackground An oligopeptide hepcidin is encoded by the human HAMP gene (Hamp in mice). Its deficiency can result in iron overload, while excess may lead to iron deficiency.
Chen X +6 more
europepmc +2 more sources
MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice [PDF]
Diabetes & Metabolism Journal, 2021 Background Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis.
Hui Ran +7 more
doaj +1 more source
Approaches for timeline reductions in pathogenesis studies using genetically modified mice
Microbiology Spectrum, 2023 Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj +1 more source
Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. [PDF]
PLoS ONE, 2013 The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival.
Melody A Furnari +4 more
doaj +1 more source
Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility [PDF]
Genetics and Molecular Biology, 2014 The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa.
Yunqiang Liu +5 more
doaj +3 more sources
Sleep in Kcna2 knockout mice [PDF]
BMC Biology, 2007 Abstract Background Shaker codes for a Drosophila voltage-dependent potassium channel. Flies carrying Shaker null or hypomorphic mutations sleep 3–4 h/day instead of 8–14 h/day as their wild-type siblings do. Shaker-like channels are conserved across species but it is unknown whether they affect sleep
Douglas, CL +6 more
openaire +6 more sources
Frontiers in Physiology, 2023 High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller +15 more
doaj +1 more source
Cdk2 Knockout Mice Are Viable [PDF]
Current Biology, 2003 Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2/cyclin E complexes are thought to be required because they phosphorylate the retinoblastoma protein and drive cells through the G1/S transition into the S phase of the cell cycle.
Eiman Aleem +4 more
openaire +3 more sources
Objective hearing threshold identification from auditory brainstem response measurements using supervised and self-supervised approaches [PDF]
BMC Neurosci 23, 81 (2022), 2021 Hearing loss is a major health problem and psychological burden in humans. Mouse models offer a possibility to elucidate genes involved in the underlying developmental and pathophysiological mechanisms of hearing impairment. To this end, large-scale mouse phenotyping programs include auditory phenotyping of single-gene knockout mouse lines.
arxiv +1 more source