Results 121 to 130 of about 565,375 (311)

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Liss Birgit, Paolo Calabresi, Auburger Georg, Silke Nuber, Javier Fernández-Ruiz, Lastres-Becker, Isabel, Double Kay L., Auburger, Georg, Lüddens Hartmut, Nuber Silke, Fernández-Ruiz, Javier, Fernández-Ruiz Javier, Gispert, Suzana, Schlaudraff Falk, Nuber, Silke, García-Arencibia Moisés, García-Arencibia, Moisés, Manfred Gerlach, Gerlach, Manfred, Double, Kay L., Kay L. Double, Alexander Kurz, Tantucci Michela, Bonin Michael, Bockhart, Vanessa, Gispert Suzana, Calabresi, Paolo, Lüddens, Hartmut, Moisés García-Arencibia, Tozzi Alessandro, Michael Bonin, Michela Tantucci, Schlaudraff, Falk, Hartmut Lüddens, Lastres-Becker Isabel, Isabel Lastres-Becker, Tantucci, Michela, Birgit Liss, Wüllner Ullrich, Ullrich Wüllner, Kurz Alexander, Vanessa Bockhart, Liss, Birgit, Falk Schlaudraff, Kurz, Alexander, Suzana Gispert, Bonin, Michael, Calabresi Paolo, Wüllner, Ullrich, Georg Auburger, Tozzi, Alessandro, Kay L Double, Alessandro Tozzi, Gerlach Manfred, Bockhart Vanessa   +54 more
core   +1 more source

Testicular development in mice lacking receptors for follicle stimulating hormone and androgen [PDF]

, 2012
Post-natal testicular development is dependent on gonadotrophin and androgen stimulation. Follicle stimulating hormone (FSH) acts through receptors (FSHR) on the Sertoli cell to stimulate spermatogenesis while androgens promote testis growth through ...
Abel, M., Ana Monteiro, Abel Margaret, Margaret Abel, Peter J. O’Shaughnessy (171628), O’Shaughnessy Peter J., Monteiro, A., O'Shaughnessy, P.J., Ana Monteiro (171632), Peter J O'Shaughnessy, Margaret Abel (171636), Monteiro Ana   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency

Biomolecules
Guanylate binding protein 5 (GBP5) is an emerging immune component that has been increasingly recognized for its involvement in autoimmune diseases, particularly inflammatory bowel disease (IBD).
Yichen Li, Wenxia Wang, Yuxuan Liu, Senru Li, Jingyu Wang, Linlin Hou   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice

, 2007
Previous in vitro studies have characterized the electrophysiological properties and molecular events associated with long-term potentiation (LTP), but as yet there are no in vivo data from molecular-level dissection that directly identify LTP as the ...
Delgado-García, José M, Valenzuela-Harrington, Mauricio, Sciarretta, Carla, Minichiello, Liliana, Gruart, Agnès   +4 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Scavenger receptor class B type I knockout mice develop extensive diet-induced coronary artery atherosclerosis in an age-dependent manner.

PLoS ONE
ObjectiveHomozygous knockout of scavenger receptor class B type I (SR-B1) in mice with atherogenic mutations (such as knockout of the apolipoprotein E or low density lipoprotein receptor genes) results in spontaneous or diet-induced coronary heart ...
Samuel K Lee, Ting Xiong, Alexander S Qian, Jeong-Ah Yoo, B Sumayyah H Sokeechand, Mark T Fuller, Peter L Gross, Richard C Austin, Suleiman A Igdoura, Bernardo L Trigatti   +9 more
doaj   +1 more source