Results 111 to 120 of about 1,668,037 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis [PDF]

, 2010
Androgens act to stimulate spermatogenesis through androgen receptors (AR) on the Sertoli cells and peritubular myoid cells (PTM). Specific ablation of the AR in either cell type will cause a severe disruption of spermatogenesis.
Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Cryptic redundancy between PAR1b and PAR1a, two members of the PAR1 kinase family, in the survival of PAR1b-knockout mice

Scientific Reports
The PAR1/MARK family of serine/threonine kinases (PAR1a-d) redundantly controls the cell polarity. PAR1b also mediates the phosphorylation of BRCA1, which promotes its nuclear translocation.
Naoko Murata-Kamiya, Adriana Alejandra Del Valle Lazarte, Ippei Kikuchi, Masanori Hatakeyama   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane‐prostanoid receptor (TPr) increases calcium transients in cardiomyocytes ...
James D. West, Cristi L. Galindo, Kyungsoo Kim, John Jonghyun Shin, James B. Atkinson, Ines Macias‐Perez, Leo Pavliv, Bjorn C. Knollmann, Jonathan H. Soslow, Larry W. Markham, Erica J. Carrier   +10 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. [PDF]

, 2012
Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance.
Bidlingmaier, Martin, Stephen C Benoit, Kristy M. Heppner (182036), Tong, J., Pfluger, Paul T., Zhao, Y., Bidlingmaier, M., Davis, Harold W., Chun-Xia Yi (182031), Kirchner, H., Erin Bartley (182062), Tong, Jenny, Tschöp, Matthias H., Bartley, Erin, Kruthaupt Traci, Gaylinn, B.D., Kirchner, Henriette, Matthias H. Tschöp (158357), Kirk M Habegger, Yongmei Zhao (182070), Kabra, D.G., Bruce D Gaylinn, Timo D. Müller (103425), Stephen C. Benoit (179150), Heppner, K.M., Joseph Anupama, Heppner, Kristy M., Kabra, Dhiraj, Davis, H.W., Yi, Chun-Xia, Traci Kruthaupt (182079), Kristy M Heppner, Joseph, A., Habegger Kirk M., Ottaway, N., Benoit, S.C., Harold W. Davis (182066), Ottaway Nickki, Zhao Yongmei, Nickki Ottaway, Yi, C.-X., Bielohuby Maximillian, Joseph, Anupama, Müller, T.D., Jenny Tong (182043), Kruthaupt, Traci, Yi Chun-Xia, Perez-Tilve Diego, Yongmei Zhao, Maximillian Bielohuby (182048), Müller, Timo D., Davis Harold W., Kirk M. Habegger (182097), Tschöp Matthias H., Anupama Joseph (182074), Dhiraj Kabra (182091), Bidlingmaier Martin, Bartley, E., Thorner, Michael O., Maximillian Bielohuby, Harold W Davis, Nickki Ottaway (182086), Anupama Joseph, Matthias H Tschöp, Benoit, Stephen C., Diego Perez-Tilve, Gaylinn Bruce D., Müller Timo D., Dhiraj Kabra, Kirchner Henriette, Jenny Tong, Traci Kruthaupt, Gaylinn, Bruce D., Paul T Pfluger, Perez-Tilve, Diego, Michael O Thorner, Diego Perez-Tilve (182114), Zhao, Yongmei, Thorner Michael O., Bielohuby, M., Tschöp, M.H., Henriette Kirchner (182039), Kabra Dhiraj, Timo D Müller, Bartley Erin, Habegger, K.M., Bielohuby, Maximilian, Michael O. Thorner (182107), Paul T. Pfluger (179123), Martin Bidlingmaier (150187), Pfluger Paul T., Bruce D. Gaylinn (182057), Chun-Xia Yi, Martin Bidlingmaier, Habegger, Kirk M, Henriette Kirchner, Pfluger, P.T., Benoit Stephen C., Kruthaupt, T., Heppner Kristy M., Erin Bartley, Tong Jenny, Ottaway, Nickki, Perez-Tilve, D., Thorner, M.O.   +104 more
core   +2 more sources

Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency

Biomolecules
Guanylate binding protein 5 (GBP5) is an emerging immune component that has been increasingly recognized for its involvement in autoimmune diseases, particularly inflammatory bowel disease (IBD).
Yichen Li, Wenxia Wang, Yuxuan Liu, Senru Li, Jingyu Wang, Linlin Hou   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source