Results 101 to 110 of about 565,375 (311)

Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice

Scientific Reports
The onset and progression mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are being studied.
Kyutaro Koyama, Akira Sakamaki, Shinichi Morita, Itsuo Nagayama, Marina Kudo, Yuto Tanaka, Naruhiro Kimura, Yoshihisa Arao, Hiroyuki Abe, Kenya Kamimura, Shuji Terai   +10 more
doaj   +1 more source

Physiological parameters of Cav2.2-knockout mice.

, 2019
A: PAS-stained sections of wild type and knockout mice kidneys. Magnification: ×100 (left column) and ×400 (middle and right column). B: Body weight (BW) and kidney weight (KW) of wild type and knockout mice before (Pre) and 14 days after UUO (Post ...
Shunsuke Takahashi (619660), Yoriaki Kaneko (2626213), Akito Maeshima (2626207), Keiichiro Mishima (7481051), Keiju Hiromura (2626216), Toru Sakairi (2626210), Hidekazu Ikeuchi (2626219), Masao Nakasatomi (6433679), Yoshihisa Nojima (184788)   +8 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury

, 2016
Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Li JS, Shi JX, Li XM, Wang H, Hu R
core  

receptor knockout mice

, 2001
1 Scald injury in Sv129+C57BL/6 mice induced a temperature and time dependent oedema formation as calculated by the extravascular accumulation of [I-125]-albumin. Oedema formation was suppressed in NK1 knockout mice compared to wildtypes at 10 (
Gerard, N P, Brain, S D; id_orcid, Andrew Rawlingson, Norma P Gerard, Rawlingson, A, Susan D Brain   +5 more
core   +1 more source

Heightened seizure severity in somatostatin knockout mice [PDF]

, 2002
Patients and experimental models of temporal lobe epilepsy display loss of somatostatinergic neurons in the dentate gyrus. To determine if loss of the peptide somatostatin contributes to epileptic seizures we examined kainate-evoked seizures and kindling
Rubinstein, Marcelo, Buckmaster, Paul S., Otero Corchón, Veronica, Low, Malcolm J.   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Thymosin Beta-4 Induces Mouse Hair Growth.

PLoS ONE, 2015
Thymosin beta-4 (Tβ4) is known to induce hair growth and hair follicle (HF) development; however, its mechanism of action is unknown. We generated mice that overexpressed Tβ4 in the epidermis, as well as Tβ4 global knockout mice, to study the role of Tβ4
Xiaoyu Gao, Hao Liang, Fang Hou, Zhipeng Zhang, Mingtu Nuo, Xudong Guo, Dongjun Liu   +6 more
doaj   +1 more source

Aggression in Knockout Mice [PDF]

ILAR Journal, 2000
R J, Nelson, S, Chiavegatto
openaire   +2 more sources

The International Gene Trap Consortium website : a portal to all publicly available gene trap cell lines in mouse [PDF]

, 2006
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to create sizeable public cell line repositories available ...
Chang, Patricia J., Conklin, B.R., Rossant, J., Skarnes, William C., Harper, C.A., Harper, C., Skarnes, W.C., Babbitt, Patricia C, Johns, Susan J., Chang, P., Chang, P.J., Huang, C., Yamamura, Ken-ichi, von Melchner, Harald, Hicks, Geoffrey G, Wurst, Wolfgang, Ferrin, Thomas E., Soriano, Philippe, Nord, Alex S., Ferrin, T., Morris, J.H., Hicks, G., Wurst, W., Cox, Antony V, Cox, A.V., Chang, Patricia J, Babbitt, Patricia C., Liu, S., Young, S.G., Babbitt, P.C., Meng, Elaine C, Young, Stephen G, Ruiz, Patricia, Stanford, W.L., Cox, A., Nord, A.S., Harper, Courtney A., Babbitt, P., Stanford, William L., Young, S., Huang, C.C., Huang, Conrad C, Johns, Susan J, Skarnes, W., Johns, S., Kawamoto, Michiko, Kawamoto, M., Stanford, W., Meng, E.C., von, Melchner, H., Skarnes, William C, Soriano, P., Johns, S.J., Huang, Conrad C., Morris, John H, Ferrin, T.E., Meng, Elaine C., Nord, A., Young, Stephen G., Conklin, B., Yamamura, K., Hicks, G.G., Stanford, William L, Ferrin, Thomas E, Stryke, Doug, Morris, J., von Melchner, H., Cox, Antony V., Stryke, D., Conklin, Bruce R, Harper, Courtney A, Meng, E., Morris, John H., Conklin, Bruce R., Liu, Songyan, Ruiz, P., Hicks, Geoffrey G., Nord, Alex S, Melchner, Harald von (Prof. Dr.), Rossant, Janet   +79 more
core   +1 more source