Results 161 to 170 of about 1,644,764 (242)

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

Advanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee, Seongchan Kim, Eui‐Sang Yu, Sian Lee, Min Jun Ko, Hyojin Lee, Dong‐Hyun Kim   +6 more
wiley   +1 more source

Engineered Peptides‐Based Hybrid‐Nested Microneedle Effectively Treat Biofilm‐Infected Diabetic Wounds

Advanced Functional Materials, EarlyView.
A hybrid‐nested microneedle/cryogel scaffold (MQW‐CMg‐MOF) is designed for efficient biofilm removal and accelerated healing of diabetic wounds. The scaffold shows substantial biofilm removal in vitro and in a preclinical diabetic swine biofilm‐infected wound model compared to the control.
Syed Muntazir Andrabi, S. M. Shatil Shahriar, Yiran Tian, Farzad Hayati, Yajuan Su, Feng Zhang, Navatha Shree Sharma, Guangshun Wang, Shannon L. Wong, Zheng Yan, Guoliang Huang, Jingwei Xie   +11 more
wiley   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Stable, Easy‐to‐Handle, Fully Autologous Electrospun Polymer‐Peptide Skin Equivalent for Severe Burn Injuries

Advanced Functional Materials, EarlyView.
A bioengineered skin equivalent composed of electrospun poly(ε‐caprolactone) (PCL) and the bioactive peptide Fmoc‐FRGD is developed for severe burn treatment. This scaffold promotes full‐thickness skin regeneration by supporting cellular adhesion and integration. In‐vitro and in‐vivo studies show enhanced mechanical stability, accelerated wound closure,
Dana Cohen‐Gerassi, Marina BenShoshan, Adi Liiani, Tomer Reuveni, Offir Loboda, Moti Harats, Josef Haik, Itzhak Binderman, Yosi Shacham‐Diamand, Amit Sitt, Ayelet Di Segni, Lihi Adler‐Abramovich   +11 more
wiley   +1 more source

Generation of Fgfr1 conditional knockout mice [PDF]

genesis, 2002
Xiaoling Xu, Cuiling Li, Wenhui Qiao, Chu-Xia Deng   +3 more
openaire   +4 more sources

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Nature, 2003
M. Holzenberger, J. Dupont, B. Ducos, P. Leneuve, A. Géloën, P. Even, P. Cervera, Y. Bouc   +7 more
semanticscholar   +1 more source

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source