Results 71 to 80 of about 1,644,764 (242)

CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology

Molecular Therapy: Methods & Clinical Development, 2021
Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming.
Dan Xiao, Weifeng Zhang, Qing Wang, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Bogoljub Ciric, Mark Curtis, Abdolmohamad Rostami, Guang-Xian Zhang   +10 more
doaj  

Spermatogenesis is normal in Tex33 knockout mice

PeerJ, 2020
Testis expressed gene 33 (Tex33) is a recently reported testis-specific gene and it is evolutionarily conserved in vertebrates. The Tex33 expression is found in cytoplasm of round spermatids in Mus musculus. However, the in vivo function of Tex33 remains unknown.
Jianli Zhou, Zhendong Zhu, Shuqin Zhao, Zuomin Zhou, Wentao Zeng, Xin Zhang, Mingxi Liu   +6 more
openaire   +3 more sources

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Molecular Neurodegeneration, 2012
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in ...
K. Hinkle, Mei Yue, B. Behrouz, J. Dächsel, S. Lincoln, Erin E. Bowles, Joel E. Beevers, B. Dugger, B. Winner, I. Prots, C. Kent, K. Nishioka, Wen‐lang Lin, D. Dickson, C. Janus, M. Farrer, H. Melrose   +16 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse. [PDF]

PLoS ONE, 2015
The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity
Franziska Mohr, Eric Krejci, Martina Zimmermann, Jochen Klein   +3 more
doaj   +1 more source

MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.

Gastroenterology, 2019
BACKGROUND & AIMS Levels of microRNA 31 (MIR31) are increased in intestinal tissues from patients with inflammatory bowel diseases and colitis-associated neoplasias. We investigated the effects of this microRNA on intestinal inflammation by studying mice
Yuhua Tian, Jiuzhi Xu, Yuan Li, Ran Zhao, Sujuan Du, Cong Lv, Wei Wu, Ruiqi Liu, Xiaole Sheng, Yongli Song, Xueyun Bi, Guilin Li, Mengzhen Li, Xi Wu, Pengbo Lou, Huiwen You, W. Cui, Jinyue Sun, Jianwei Shuai, F. Ren, Bing-Kun Zhang, M. Guo, X. Hou, Kaichun Wu, L. Xue, Hongquan Zhang, M. Plikus, Y. Cong, C. Lengner, Zhanju Liu, Zhengquan Yu   +30 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Gadd45a knockout mice resemble p53 knockouts [PDF]

Genome Biology, 2000
Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
openaire   +2 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload‐Induced Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Alterations of energetic metabolism are suggested to be an important contributor to pressure overload (PO)‐induced heart failure. Our previous study reveals that knockout of endothelial Sirtuin 3 (SIRT3) alters glycolysis and impairs diastolic
Heng Zeng, Xiaochen He, Jian‐Xiong Chen   +2 more
doaj   +1 more source