Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]
, 2017 This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5 ...
Aguiar, Cristhiane Favero +25 more
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Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. [PDF]
PLoS ONE, 2013 A positive relationship between obesity and asthma has been well documented. The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses.
Marina Ciarallo Calixto +9 more
doaj +1 more source
Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice. [PDF]
PLoS ONE, 2014 Synphilin-1 is a cytoplasmic protein that has been shown to be involved in the control of energy balance. Previously, we reported on the generation of a human synphilin-1 transgenic mouse model (SP1), in which overexpression of human synphilin-1 resulted
Xueping Li +10 more
doaj +1 more source
Metabolic effects of CCL5 deficiency in lean and obese mice
Frontiers in Immunology, 2023 Accumulation and activation of immunocytes in adipose tissues are essential to obesity-induced inflammation and insulin resistance. Chemokines are pivotal for the recruitment of immunocytes in adipose tissue during obesity. Chemokine (C-C motif) ligand 5
Hui Zhou +22 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Muscle weakness is a frequently occurring complication of sepsis, associated with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced muscle wasting and weakness.
Wouter Vankrunkelsven +8 more
doaj +1 more source
Alterations in oral [1-(14)C] 18:1n-9 distribution in lean wild-type and genetically obese (ob/ob) mice. [PDF]
PLoS ONE, 2015 Obesity may result from altered fatty acid (FA) disposal. Altered FA distribution in obese individuals is poorly understood. Lean wild-type C57BL/6J and obese C57BL/6Job/ob mice received an oral dose of [1-(14)C]18:1n-9 (oleic acid), and the ...
Xinxia Wang +4 more
doaj +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
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Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice [PDF]
, 2017 Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron.
Arefiev, Yevgeniy +12 more
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Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice [PDF]
, 2020 Pomace olive oil, an olive oil sub-product, is a promising source of bioactive triterpenoids such as oleanolic acid and maslinic acid. Considering the vascular actions of pomace olive oil and the potential effects of the isolated oleanolic acid on ...
Claro Cala, Carmen María +6 more
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Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]
, 2019 There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A +6 more
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