Results 21 to 30 of about 239,216 (213)

Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]

, 2016
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann, Gerasimidis, Konstantinos, Khan, Muhammad Jaffar, Shaikh, M. Guftar   +3 more
core   +3 more sources

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice

Pharmaceutical Biology, 2017
Context: Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy in treating obesity is limited.
Xin Yang, Qian Wang, Zeng-run Pang, Meng-ran Pan, Wen Zhang   +4 more
doaj   +1 more source

Alterations in the mammary gland and tumor microenvironment of formerly obese mice

BMC Cancer, 2023
Background Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adipose tissue fibrosis.
Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Yue Xiong, Abbey E. Williams, Lisa M. Arendt   +5 more
doaj   +1 more source

Allergic Airway Responses in Obese Mice [PDF]

American Journal of Respiratory and Critical Care Medicine, 2007
Epidemiologic data indicate an increased incidence of asthma in the obese.To determine whether obese mice exhibit augmented pulmonary responses after allergen sensitization and challenge.Lean, wild-type (C57BL/6), obese ob/ob, and obese db/db mice were sensitized to ovalbumin (OVA), and then challenged with aerosolized OVA or phosphate-buffered saline (
Richard A, Johnston, Ming, Zhu, Yadira M, Rivera-Sanchez, Frank L, Lu, Todd A, Theman, Lesley, Flynt, Stephanie A, Shore   +6 more
openaire   +2 more sources

Ciliary ARL13B prevents obesity in mice.

bioRxiv : the preprint server for biology, 2023
Cilia are near ubiquitous small, cellular appendages critical for cell-to-cell communication. As such, they are involved in diverse developmental and homeostatic processes, including energy homeostasis. ARL13B is a regulatory GTPase highly enriched in cilia.
Terry, Tiffany T., Gigante, Eduardo D., Alexandre, Coralie M., Brewer, Kathryn M., Engle, Staci E., Yue, Xinyu, Berbari, Nicolas F., Vaisse, Christian, Caspary, Tamara   +8 more
openaire   +3 more sources

Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]

, 2017
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica, Gonzalez, Betina, Gonzalez, Candela Rocio, Urbano Suarez, Francisco Jose   +3 more
core   +2 more sources

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. [PDF]

, 2014
The current dogma is that obesity-associated hepatic inflammation is due to increased Kupffer cell (KC) activation. However, recruited hepatic macrophages (RHMs) were recently shown to represent a sizable liver macrophage population in the context of ...
Bandyopadhyay, Gautam, Bogner-Strauss, Juliane G, Chi, Tyler J, Chung, Heekyung, Evans, Ronald M, Franck, Niclas, Hah, Nasun, Heinrichsdorff, Jan, Mayoral, Rafael, Morinaga, Hidetaka, Oh, Da Young, Olefsky, Jerrold M, Osborn, Olivia, Pessentheiner, Ariane R, Walenta, Evelyn   +14 more
core   +2 more sources

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]

, 2020
Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun, Choi, Jeong-Won, Choi, Sun Sil, Eom, Hye-Jin, Hyun, Ji-Min, Jang, Hyun-Jun, Khim, Keon Woo, Lee, Eujin, Lee, Yo Han, Nam, Dougu, Park, Tae-Eun, Yoon, Sora   +11 more
core   +1 more source

Pyruvate induces torpor in obese mice [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Mice can reduce their body temperature and metabolic rate and enter torpor when they are subjected to cold, calorie deprivation, or administration of some metabolic inhibitors. Here we show that administration of pyruvate, a key metabolic intermediate and substrate for gluconeogenesis, induces torpor in obese mice ...
Marion, Soto, Lucie, Orliaguet, Michelle L, Reyzer, M Lisa, Manier, Richard M, Caprioli, C Ronald, Kahn   +5 more
openaire   +2 more sources

Obesity and metabolic syndrome induce hyperfiltration, glomerulomegaly, and albuminuria in obese ovariectomized female mice and obese male mice

Menopause, 2021
Abstract Objective: Obese patients with metabolic syndrome have a high risk of chronic kidney disease. The prevalence of obesity, metabolic syndrome, and insulin resistance increase in women after menopause, as does the risk of chronic kidney disease.
Pérez Pérez, José Antonio, Rodríguez-Rodríguez, Ana Elena, Donate Correa, Javier, Luis Lima, Sergio, Díaz Martín, Laura, Rodríguez Gonzá´lez, Covadonga, Acosta Gonzá´lez, Nieves Guadalupe, Fumero, Cecilia, Navarro Díaz, Maruja, López Á´lvarez, Dolores, Villacampa Jiménez, Jacobo, Navarro Gonzá´lez, José Antonio, Ortiz, Alberto, Porrini, Esteban   +13 more
openaire   +4 more sources