Results 31 to 40 of about 241,974 (292)

Pyruvate induces torpor in obese mice [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Mice can reduce their body temperature and metabolic rate and enter torpor when they are subjected to cold, calorie deprivation, or administration of some metabolic inhibitors. Here we show that administration of pyruvate, a key metabolic intermediate and substrate for gluconeogenesis, induces torpor in obese mice ...
Marion, Soto, Lucie, Orliaguet, Michelle L, Reyzer, M Lisa, Manier, Richard M, Caprioli, C Ronald, Kahn   +5 more
openaire   +2 more sources

Obesity and metabolic syndrome induce hyperfiltration, glomerulomegaly, and albuminuria in obese ovariectomized female mice and obese male mice

Menopause, 2021
Abstract Objective: Obese patients with metabolic syndrome have a high risk of chronic kidney disease. The prevalence of obesity, metabolic syndrome, and insulin resistance increase in women after menopause, as does the risk of chronic kidney disease.
Pérez Pérez, José Antonio, Rodríguez-Rodríguez, Ana Elena, Donate Correa, Javier, Luis Lima, Sergio, Díaz Martín, Laura, Rodríguez Gonzá´lez, Covadonga, Acosta Gonzá´lez, Nieves Guadalupe, Fumero, Cecilia, Navarro Díaz, Maruja, López Á´lvarez, Dolores, Villacampa Jiménez, Jacobo, Navarro Gonzá´lez, José Antonio, Ortiz, Alberto, Porrini, Esteban   +13 more
openaire   +4 more sources

Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese[S]

Journal of Lipid Research, 2016
Alcohol- and obesity-related liver diseases often coexist. The hepatic lipidomics due to alcohol and obesity interaction is unknown. We characterized the hepatic lipidome due to 1) alcohol consumption in lean and obese mice and 2) obesity and alcohol ...
Puneet Puri, Jun Xu, Terhi Vihervaara, Riikka Katainen, Kim Ekroos, Kalyani Daita, Hae-Ki Min, Andrew Joyce, Faridoddin Mirshahi, Hidekazu Tsukamoto, Arun J. Sanyal   +10 more
doaj   +1 more source

PI3Kα inhibition reduces obesity in mice

Aging, 2016
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity.
Lopez-Guadamillas, Elena, Muñoz-Martin, Maribel, Martinez, Sonia, Pastor, Joaquin, Fernandez-Marcos, Pablo J., Serrano, Manuel   +5 more
openaire   +3 more sources

Malaria and obesity: obese mice are resistant to cerebral malaria [PDF]

Malaria Journal, 2008
The relationship between malaria and obesity are largely unknown. This is partly due to the fact that malaria occurs mainly in tropical areas where, until recently, obesity was not prevalent. It now appears, however, that obesity is emerging as a problem in developing countries.
Robert, Vincent, Bourgouin, Catherine, Depoix, Delphine, Thouvenot, C, Lombard, M-N, Grellier, Philippe   +5 more
openaire   +4 more sources

Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]

, 2017
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica, Gonzalez, Betina, Gonzalez, Candela Rocio, Urbano Suarez, Francisco Jose   +3 more
core   +2 more sources

Influence of obesity on remodeling of lung tissue and organization of extracellular matrix after blunt thorax trauma

Respiratory Research, 2020
Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To date, lung tissue regeneration and
Pengfei Xu, Fabian Gärtner, Adrian Gihring, Congxing Liu, Timo Burster, Martin Wabitsch, Uwe Knippschild, Stephan Paschke   +7 more
doaj   +1 more source

Obesity impairs resistance to Leishmania major infection in C57BL/6 mice.

PLoS Neglected Tropical Diseases, 2020
An association between increased susceptibility to infectious diseases and obesity has been described as a result of impaired immunity in obese individuals. It is not clear whether a similar linkage can be drawn between obesity and parasitic diseases. To
Vinicius Dantas Martins, Franciele Carolina Silva, Felipe Caixeta, Matheus Batista Carneiro, Graziele Ribeiro Goes, Lícia Torres, Sara Cândida Barbosa, Leonardo Vaz, Nivea Carolina Paiva, Cláudia Martins Carneiro, Leda Quercia Vieira, Ana Maria Caetano Faria, Tatiani Uceli Maioli   +12 more
doaj   +1 more source

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]

, 2015
The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M, Costanzo, Anne, Gareau, Melanie G, Jameson, Julie M, Johnson, Andrew MF, Olefsky, Jerrold M, Quehenberger, Oswald   +6 more
core   +2 more sources

Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy

International Journal of Endocrinology, 2015
Objective. Tauroursodeoxycholic acid (TUDCA) has been considered an important regulator of energy metabolism in obesity. However, the mechanism underlying how TUDCA is involved in insulin resistance is not fully understood. We tested the effects of TUDCA
Qinyue Guo, Qindong Shi, Huixia Li, Jiali Liu, Shufang Wu, Hongzhi Sun, Bo Zhou   +6 more
doaj   +1 more source