Results 251 to 260 of about 2,492,262 (305)
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The stereochemistry of the Michael addition
Tetrahedron, 1968Abstract The nature of the products obtained in the addition of diethyl malonate to 4-t-butyl-1-cyanocyclohexene under various conditions of solvents, catalysts, and temperature, and their geometries have been determined. In protic solvents, and under conditions of kinetic control, the main product is diethyl cis -t-butyl-1-cyano-2 ...
R.A. Abramavitch, D.L. Struble
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Acid catalyzed michael additions to artemisitene
Bioorganic & Medicinal Chemistry Letters, 2000A series of 14-substituted-artemisinin and 9-epiartemisinin derivatives was prepared by a titanium-tetrachloride catalyzed addition of trimethylsilyl enol ethers to artemisitene. Several compounds were four to seven times more active than artemisinin against Plasmodium falciparum.
J, Ma, E, Weiss, D E, Kyle, H, Ziffer
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Fluorapatite: efficient catalyst for the Michael addition
Tetrahedron Letters, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Mohamed Zahouily +5 more
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Michael Addition of Manganese Enolates to Nitroolefins
Synlett, 2007The Michael addition to nitroolefins of manganese enolates derived from an array of ketones is reported. The desired 1,4-adducts are obtained in high yield and excellent diastereo- and regioselectivity, the sole kinetic adduct being obtained in the case of nonsymmetrical ketones.
Micheletti G. +4 more
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Michael addition drugs and cancer
Some of the earliest anticancer drugs were alkylating agents, capable of covalently modifying critical cellular nucleophiles in proteins and nucleic acids. For many years, adapting another type of covalent reaction, Michael addition reactions, which involve the nucleophilic attack of a carbon nucleophile on an α,β-unsaturated carbonyl compound, have ...Kenneth D, Tew +5 more
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ChemInform Abstract: MICHAEL ADDITIONS OF BENZOINS VERSUS MICHAEL‐STETTER ADDITIONS OF ALDEHYDES
Chemischer Informationsdienst, 1980AbstractBei der Addition von Aldehyden an Chalkon (II) nach Michael‐Stetter spielt die sterische Hinderung in den verwendeten Thiazoliumsalz‐Katalysatoren (III) eine wesentliche Rolle; aus Furfural (I) und (II) erhält man unterschiedliche Anteile an den Addukten (IV) und (V) über diskutierte Zwischenstufen.
J. CASTELLS +6 more
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Organocatalytic Asymmetric Aza‐Michael Additions
Chemistry – A European Journal, 2009AbstractThe catalytic aza‐Michael addition is an important reaction within synthetic organic chemistry, given the significance of the biologically and synthetically interesting products, such as β‐amino acids and β‐lactams. In the last decade organocatalysis emerged as a powerful tool in asymmetric synthesis and had a large impact on the development of
Dieter, Enders +2 more
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Michael and anti-Michael additions to benzoyl(trifluoromethyl)acetylene
The Journal of Organic Chemistry, 1986Etude des aspects cinetiques et thermodynamiques d'additions nucleophiles a l'ynone du ...
Carl L. Bumgardner +2 more
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