Results 41 to 50 of about 2,492,262 (305)

“Anti-Michael addition” of Grignard reagents to sulfonylacetylenes: synthesis of alkynes [PDF]

, 2017
In this work, the addition of Grignard reagents to arylsulfonylacetylenes, which undergoes an “anti-Michael addition”, resulting in their alkynylation under very mild conditions is described.
Alemán, José, Boughani, Lazhar, Esteban, Francisco, Fraile, Alberto, García Ruano, José L.   +4 more
core   +2 more sources

The applicability of sulfoxide Michael acceptor – 2­-(S)-­[(4­-methylphenyl)sulfinyl]-­2­-cyclopenten­-1­-one in constructing the carbon skeleton of 9,11­-secosterols [PDF]

Proceedings of the Estonian Academy of Sciences
A possibility of use of the Michael addition reaction of the A,B­-ring fragment enolate to sulfoxide 2­-(S)-­[(4­-methylphenyl)sulfinyl]-­2­-cyclopenten­-1­-one for constructing the main skeleton of 9,11­-secosterols was studied.
Kristi Rõuk, Marek Kõllo, Ivar Järving, Margus Lopp   +3 more
doaj   +1 more source

Microwave assisted synthesis of some new coumarin-pyrazoline hybrids and their antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2015
A series of pyrazolines 4a-g have been synthesized by Michael addition of chalcones 3a-g with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation.
Ashok Dongamanti, Lakshmi Bommidi Vijaya, Ravi Sidda, Ganesh Arram   +3 more
doaj   +1 more source

Poly(amidoamine)-BSA conjugates synthesised by Michael addition reaction retained enzymatic activity [PDF]

, 2016
Polymer-protein conjugates are key to overcome some of the therapeutic protein limitations, including inefficient intracellular delivery. Poly(amidoamine)s are bioresponsive polyelectrolytes, which can form complexes with proteins and promote their ...
Abuchowski, Basak, Bell, Besheer, Boyer, Caliceti, Chen, Coué, D. R. Garcia, De, Dubois, Dubois, Ferruti, Ferruti, Gauthier, Grover, Heredia, Heredia, Hermanson, Isom, Lavignac, Lavignac, Lavignac, Liu, Liu, Lu, Lutz, Malgesini, Miyamoto, Moriyama, N. Lavignac, Nauka, Nicolas, Pasut, Pelegri-O'Day, Ranucci, Richardson, Sakurai, Sasaki, Segel, Seo, Shimoboji, Simakova, Suthiwangcharoen, Thilakarathne, Treetharnmathurot, Urban, Vanparijs, Voet, Wallat, Yoshimura, Zarafshani, Zhang, Zhang, Zhao   +54 more
core   +1 more source

4′-(N-(2-Cyanoethyl)pyrrol-2-yl)-2,2′:6′,2″-terpyridine

Molbank, 2023
The preparation and characterization of a new multi-functionalized terpyridine molecule featuring a pyrrole heterocycle and a cyano group is described. This new compound was obtained via a KF/alumina-catalyzed Michael addition of 4′-(pyrrol-2-yl)-2,2′:6′,
Jérôme Husson
doaj   +1 more source

Simple one pot preparation of chemical hydrogels from cellulose dissolved in cold LiOH/urea [PDF]

, 2020
In this work, non-derivatized cellulose pulp was dissolved in a cold alkali solution (LiOH/urea) and chemically cross-linked with methylenebisacrylamide (MBA) to form a robust hydrogel with superior water absorption properties.
Lindman, Björn, Medronho, Bruno, Norgren, Magnus, Yang, Jiayi   +3 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Stereochemical Studies on a New Ciramadol Analogue by NMR-Spectroscopy [PDF]

, 1994
The absol. configuration of a Ciramadol analogue obtained from (-)-menthone is established by 'H-NMR-. simulated NMR-, COSY-90-, and NOEmeasurements. The final compound 2-(a-1 -pyrrolidino)benzy 1-4-isopropyl- 1 -methyl-cyclohexan-3-one (4b), e.g..
Akgün, H., Burgemeister, Thomas, Ertan, M., Wiegrebe, Wolfgang, Özarslan, Ö.   +4 more
core  

Synthesis of interesting β-nitrohydrazides through a thiourea organocatalysed aza-Michael addition [PDF]

, 2014
The synthesis of antimicrobial β-nitrohydrazides, as the target product of our reaction, is reached for the first time under organocatalytic enantioselective conditions.
Alcaine, Ana, Herrera, Raquel P., Marqués-López, Eugenia   +2 more
core   +2 more sources