Results 1 to 10 of about 969,825 (379)

Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

Gut Microbes, 2023
Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals with microbiota sequencing enrolled in the American Gut Project.
Qi Su, Hein M Tun, Qin Liu, Yun Kit Yeoh, Joyce Wing Yan Mak, Francis KL Chan, Siew C Ng   +6 more
doaj   +1 more source

Faecal microbiome-based machine learning for multi-class disease diagnosis

Nature Communications, 2022
Here, using fecal metagenomics data of 2,320 individuals, the authors develop a microbiome-based machine learning approach showing high accuracy for multi-class disease diagnosis, highlighting its potential application in improving noninvasive ...
Qi Su, Qin Liu, Raphaela Iris Lau, Jingwan Zhang, Zhilu Xu, Yun Kit Yeoh, Thomas W. H. Leung, Whitney Tang, Lin Zhang, Jessie Q. Y. Liang, Yuk Kam Yau, Jiaying Zheng, Chengyu Liu, Mengjing Zhang, Chun Pan Cheung, Jessica Y. L. Ching, Hein M. Tun, Jun Yu, Francis K. L. Chan, Siew C. Ng   +19 more
doaj   +1 more source

Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

Signal Transduction and Targeted Therapy, 2023
The role of gut microbiota in modulating the durability of COVID-19 vaccine immunity is yet to be characterised. In this cohort study, we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline, 1 month, and 6 months post
Ye Peng, Lin Zhang, Chris K. P. Mok, Jessica Y. L. Ching, Shilin Zhao, Matthew K. L. Wong, Jie Zhu, Chunke Chen, Shilan Wang, Shuai Yan, Biyan Qin, Yingzhi Liu, Xi Zhang, Chun Pun Cheung, Pui Kuan Cheong, Ka Long Ip, Adrian C. H. Fung, Kenneth K. Y. Wong, David S. C. Hui, Francis K. L. Chan, Siew C. Ng, Hein M. Tun   +21 more
doaj   +1 more source

Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome

Nature Communications, 2022
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range MGEs ...
Samuel C. Forster, Junyan Liu, Nitin Kumar, Emily L. Gulliver, Jodee A. Gould, Alejandra Escobar-Zepeda, Tapoka Mkandawire, Lindsay J. Pike, Yan Shao, Mark D. Stares, Hilary P. Browne, B. Anne Neville, Trevor D. Lawley   +12 more
doaj   +1 more source

Patent Human Infections with the Whipworm, Trichuris trichiura, Are Not Associated with Alterations in the Faecal Microbiota [PDF]

, 2013
Background: The soil-transmitted helminth (STH), Trichuris trichiura colonises the human large intestine where it may modify inflammatory responses, an effect possibly mediated through alterations in the intestinal microbiota.
A Olsen, AJ Bancroft, AL Kau, AL Moncayo, Alan W. Walker, AW Walker, C De Filippo, C Quince, CA Figueiredo, DA Bundy, EG Zoetendal, EK Costello, GD Wu, H Sokol, J Bethony, J Maukonen, JL Shin, Jorge Reyes, JS Crowther, Julian Parkhill, KS Hayes, LC Rodrigues, LS Mansfield, M Reina Ortiz, Maritza Vaca, Martha Chico, MI Bahl, MJ Broadhurst, MP Bryant, N Segata, P Endara, P Steinmann, PB Eckburg, PD Schloss, Philip Cooper, RW Li, RW Li, RW Summers, RW Summers, S Wu, ST Walk, Stefan Bereswill, Susannah J. Salter, T Yatsunenko, TT MacDonald, VB Young, Y Suputtamongkol   +46 more
core   +16 more sources

Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle

Genome Biology, 2021
Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota.
Hilary P. Browne, Alexandre Almeida, Nitin Kumar, Kevin Vervier, Anne T. Adoum, Elisa Viciani, Nicholas J. R. Dawson, Samuel C. Forster, Claire Cormie, David Goulding, Trevor D. Lawley   +10 more
doaj   +1 more source

Multi-kingdom gut microbiota analyses define COVID-19 severity and post-acute COVID-19 syndrome

Nature Communications, 2022
Here, by performing an integrative multi-omics analysis coupled to clinical features of COVID-19 patients prospectively followed for up to 6 month, the authors identify specific gut microbiome patterns associated with disease severity and development of ...
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng   +15 more
doaj   +1 more source

Movement ecology and sex are linked to barn owl microbial community composition. [PDF]

, 2020
The behavioural ecology of host species is likely to affect their microbial communities, because host sex, diet, physiology, and movement behaviour could all potentially influence their microbiota.
Bowie, Rauri CK, Charter, Motti, Corl, Ammon, Getz, Wayne M, Kamath, Pauline L, Nathan, Ran, Rozman, Gabe, Toledo, Sivan, Turjeman, Sondra   +8 more
core   +1 more source

Prevotella species in the human gut is primarily comprised of Prevotella copri, Prevotella stercorea and related lineages

Scientific Reports, 2022
Prevotella species in the human gut microbiome are primarily comprised of Prevotella copri, and its diversity and function were recently investigated in detail. Much less is known about other Prevotella species in the human gut.
Yun Kit Yeoh, Yang Sun, Lawrence Yuk Ting Ip, Lan Wang, Francis K. L. Chan, Yinglei Miao, Siew C. Ng   +6 more
doaj   +1 more source

Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice [PDF]

, 2013
Background: Murine models are a crucial component of gut microbiome research. Unfortunately, a multitude of genetic backgrounds and experimental setups, together with inter-individual variation, complicates cross-study comparisons and a global ...
Brinkman, Brigitta, Cauwe, Benedicte, Garcia Yunta, Roberto, Hildebrand, Falk, Liston, Adrian, Nguyen, (Thi Loan Anh, Raes, Jeroen, Vandenabeele, Peter   +7 more
core   +3 more sources