Results 51 to 60 of about 723,806 (335)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Associations among Wine Grape Microbiome, Metabolome, and Fermentation Behavior Suggest Microbial Contribution to Regional Wine Characteristics. [PDF]

, 2016
UnlabelledRegionally distinct wine characteristics (terroir) are an important aspect of wine production and consumer appreciation. Microbial activity is an integral part of wine production, and grape and wine microbiota present regionally defined ...
Allen, Greg, Bokulich, Nicholas A, Collins, Thomas S, Ebeler, Susan E, Heymann, Hildegarde, Masarweh, Chad, Mills, David A   +6 more
core   +2 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism

mSystems
Honeybees (Apis mellifera), as social insects, exhibit complex social behaviors and cognitive functions. The short lifespan and stable gut microorganisms of honeybees provide certain availability as a rapid and high-flux animal model for aging research ...
Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang   +11 more
doaj   +1 more source

Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota

Frontiers in Aging Neuroscience, 2022
Recent evidence points out the role of the gut microbiota in the aging process. However, the specific changes and relevant interventions remain unclear. In this study, Senescence Accelerated Mouse-Prone 8 (SAMP8) mice were divided into four groups; young-
Nana Zhang, Nana Zhang, Yan Zhang, Yan Zhang, Zikai Wang, Fei Pan, Rongrong Ren, Zhengpeng Li, Huijun Zhao, Xi Luo, Zongwei Li, Lei Wang, Rui Mo, Gang Sun, Lihua Peng, Ming Ni, Yunsheng Yang, Yunsheng Yang   +17 more
doaj   +1 more source

Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]

, 2016
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann, Gerasimidis, Konstantinos, Khan, Muhammad Jaffar, Shaikh, M. Guftar   +3 more
core   +3 more sources

MICROBIOTA

Revista de la Sociedad Argentina de Diabetes, 2020
La microbiota intestinal se considera un órgano que posee un importante impacto en la salud del huésped, cuya formación en los dos y tres primeros años de vida es clave en el futuro desarrollo de la salud/enfermedad del individuo.
openaire   +3 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Soil domestication by rice cultivation results in plant-soil feedback through shifts in soil microbiota. [PDF]

, 2019
BackgroundSoils are a key component of agricultural productivity, and soil microbiota determine the availability of many essential plant nutrients.
Edwards, Joseph, Kilmer, John, Liechty, Zachary, Nguyen, Bao, Ni, Jiadong, Phillips, Gregory, Santos-Medellín, Christian, Sundaresan, Venkatesan, Veliz, Esteban   +8 more
core   +1 more source