Results 61 to 70 of about 969,825 (379)

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Science, 2020
New fecal microbiota for cancer patients The composition of the gut microbiome influences the response of cancer patients to immunotherapies. Baruch et al. and Davar et al.
E. Baruch, I. Youngster, Guy Ben-Betzalel, R. Ortenberg, A. Lahat, L. Katz, K. Adler, Daniela Dick-Necula, S. Raskin, N. Bloch, D. Rotin, Liat Anafi, C. Avivi, Jenny Melnichenko, Yael Steinberg-Silman, R. Mamtani, H. Harati, N. Asher, R. Shapira-Frommer, Tal Brosh-Nissimov, Y. Eshet, Shira Ben-Simon, O. Ziv, M. A. W. Khan, M. Amit, N. Ajami, I. Barshack, J. Schachter, J. Wargo, O. Koren, G. Markel, B. Boursi   +31 more
semanticscholar   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Probiotic potential of Phocaeicola coprocola in modulating learning and memory behaviors in the honeybee model

Frontiers in Microbiology
IntroductionGut microbial therapy has emerged as a prominent research topic for brain function and disorders. The depletion of Phocaeicola coprocola has been reported in various brain-related conditions, suggesting its possible neuroprotective and ...
Mengqi Xu, Mengqi Xu, Xiaohan Zhang, Xiaohan Zhang, Xi Luo, Guanzhou Zhou, Guanzhou Zhou, Nana Zhang, Xiaoyan Chi, Xiaoyan Chi, Rongrong Ren, Lihua Peng, Gang Sun, Yunsheng Yang, Yunsheng Yang   +14 more
doaj   +1 more source

Lacticaseibacillus paracasei sh2020 induced antitumor immunity and synergized with anti-programmed cell death 1 to reduce tumor burden in mice

Gut Microbes, 2022
The gut microbiota was emerging as critical regulatory elements in shaping the outcome of cancer immunotherapy. However, the underlying mechanisms by which the gut commensal species enhance antitumor immunity remain largely unexplored. Here, we show that
Shi-Long Zhang, Bing Han, Yu-Qin Mao, Zheng-Yan Zhang, Zhan-Ming Li, Chao-Yue Kong, You Wu, Guo-Qiang Chen, Li-Shun Wang   +8 more
doaj   +1 more source

Salivary microbiota reflecting changes in subgingival microbiota

Microbiology Spectrum
ABSTRACT The purpose of this study was to determine whether subgingival microbial changes according to the severity of periodontal disease and following the non-surgical periodontal treatment of periodontitis are reflected in the saliva microbiota.
Jae-Suk Jung, Joong-Ki Kook, Soon-Nang Park, Yun Kyong Lim, Geum Hee Choi, Sunjin Kim, Suk Ji   +6 more
openaire   +3 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance. [PDF]

, 2019
The composition of the gastrointestinal microbiota and associated metabolites changes dramatically with diet and the development of obesity. Although many correlations have been described, specific mechanistic links between these changes and glucose ...
Chan, Luisa S, Chordia, Mahendra D, El Ouarrat, Dalila, Han, Andrew W, Jain, Mohit, Johnson, Andrew MF, Lee, Yun Sok, Mahmood, Nadir A, Ofrecio, Jachelle M, Olefsky, Jerrold M, Pan, Dongfeng, Riopel, Matthew, Ryan, Caitlin N, Watrous, Jeramie D, Wollam, Joshua, Xu, Yong-Jiang, Ying, Wei   +16 more
core   +1 more source

Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis [PDF]

, 2016
Important insights have recently been gained in our understanding of the intricate relationship in the intestinal milieu between the vertebrate host mucosal immune response, commensal bacteria, and helminths. Helminths are metazoan worms (macrobiota) and
Gause, William C., Maizels, Rick M.
core   +1 more source

Microbiota in sports

Archives of Microbiology, 2022
AbstractThe influence of microbiota on the human body is currently the subject of many studies. The composition of bacteria colonizing the gastrointestinal tract varies depending on genetic make-up, lifestyle, use of antibiotics or the presence of diseases. The diet is also important in the species diversity of the microbiota. This study is an analysis
Katarzyna Mańkowska, Małgorzata Marchelek-Myśliwiec, Piotr Kochan, Danuta Kosik-Bogacka, Tomasz Konopka, Bartłomiej Grygorcewicz, Paulina Roszkowska, Elżbieta Cecerska-Heryć, Aldona Siennicka, Justyna Konopka, Barbara Dołęgowska   +10 more
openaire   +2 more sources