Results 131 to 140 of about 15,118,660 (165)

Monte Carlo simulations of 241 Am α -particle energy distribution, LET distribution, and absorbed dose in a cell layer. [PDF]

Med Phys
Araszkiewicz M, Tymińska K, Kaźmierczak U, Chuchała P, Grzyb J, Kamińska P, Kwiatkowski R, Maleszewska M, Malinowska A, Maliszewska-Olejniczak K, Paterczyk B, Korgul A.   +11 more
europepmc   +1 more source

Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions. [PDF]

Phys Med Biol
Onecha VV, Schuemann J, Paganetti H, Bertolet A.   +3 more
europepmc   +1 more source

Adaptation of stochastic microdosimetric kinetic model for charged-particle therapy treatment planning

Physics in Medicine & Biology, 2018
Abstract The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model. In the SMK model, the radiation
T Inaniwa, N Kanematsu
exaly   +5 more sources

Microdosimetric-Kinetic Model for Radio-enhancement of Gold Nanoparticles: Comparison with LEM

Radiation Research, 2020
Numerous studies have strongly supported the application of gold nanoparticles (GNPs) as radio-enhanced agents. In our previous study, the local effect model (LEM I) was adopted to predict the cell survival for MDA-MB-231 cells exposed to 150 kVp X rays after 500 µg/ml GNPs treatment.
Hyejin, Kim, Wonmo, Sung, Sung-Joon, Ye
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Development of modified microdosimetric kinetic model for relative biological effectiveness in proton therapy

Radiation and Environmental Biophysics, 2022
To predict the biological effects of ionising radiation, the quantity of biological dose is introduced instead of the physical absorbed dose. In proton therapy, a constant relative biological effectiveness (RBE) of 1.1 is usually applied clinically as recommended by the International Commission of Radiation Units and Measurements. This study presents a
Hossein Taghipour, Payvand Taherparvar
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Adaptation of the microdosimetric kinetic model to hypoxia

Physics in Medicine & Biology, 2016
Abstract Ion beams present a potential advantage in terms of treatment of lesions with hypoxic regions. In order to use this potential, it is important to accurately model the cell survival of oxic as well as hypoxic cells. In this work, an adaptation of the microdosimetric kinetic (MK) model making it possible to account for cell ...
C, Bopp, R, Hirayama, T, Inaniwa, A, Kitagawa, N, Matsufuji, K, Noda   +5 more
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Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model

Physics in Medicine and Biology, 2010
We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam.
Taku, Inaniwa, Takuji, Furukawa, Yuki, Kase, Naruhiro, Matsufuji, Toshiyuki, Toshito, Yoshitaka, Matsumoto, Yoshiya, Furusawa, Koji, Noda   +7 more
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Formation of spread-out Bragg peak for helium-ion beam using microdosimetric kinetic model

Physica Medica, 2023
To evaluate the applicability of microdosimetric kinetic model (MKM) to helium-ion therapy by forming a spread-out Bragg peak (SOBP) of a helium-ion beam using the MKM developed for carbon-ion radiotherapy and confirming the predictions in biological experiments.Using a ridge filter, a 90-mm wide SOBP for a 210 MeV/u helium-ion beam was created in a ...
Takashi Akagi, Takuya Maeda, Masaki Suga, Tomohiro Yamashita   +3 more
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A Microdosimetric-Kinetic Model for Cell Killing by Protracted Continuous Irradiation II: Brachytherapy and Biologic Effective Dose

Radiation Research, 2014
Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources.
Roland B, Hawkins, Taku, Inaniwa
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