Results 141 to 150 of about 15,118,660 (165)
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Physics in Medicine & Biology, 2021
Abstract For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges.
Taku Inaniwa +4 more
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Abstract For hypo-fractionated multi-ion therapy (HFMIT), the stochastic microdosimetric kinetic (SMK) model had been developed to estimate the biological effectiveness of radiation beams with wide linear energy transfer (LET) and dose ranges.
Taku Inaniwa +4 more
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Radiation Research, 2003
The microdosimetric-kinetic (MK) model for cell killing by ionizing radiation is summarized. An equation based on the MK model is presented which gives the dependence of the relative biological effectiveness in the limit of zero dose (RBE1) on the linear energy transfer (LET).
Roland B Hawkins
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The microdosimetric-kinetic (MK) model for cell killing by ionizing radiation is summarized. An equation based on the MK model is presented which gives the dependence of the relative biological effectiveness in the limit of zero dose (RBE1) on the linear energy transfer (LET).
Roland B Hawkins
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A modified microdosimetric kinetic model for relative biological effectiveness calculation
Physics in Medicine & Biology, 2017Abstract In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific ...
Yizheng, Chen +4 more
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International Journal of Radiation Biology, 2021
The stochastic microdosimetric kinetic (SMK) model is one of the most sophisticated and precise models used in the estimation of the relative biological effectiveness of carbon-ion radiotherapy (CRT) and boron neutron capture therapy (BNCT). However, because of its complicated and time-consuming calculation procedures, it is nearly impractical to ...
Tatsuhiko, Sato +4 more
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The stochastic microdosimetric kinetic (SMK) model is one of the most sophisticated and precise models used in the estimation of the relative biological effectiveness of carbon-ion radiotherapy (CRT) and boron neutron capture therapy (BNCT). However, because of its complicated and time-consuming calculation procedures, it is nearly impractical to ...
Tatsuhiko, Sato +4 more
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Microdosimetric analysis of proton boron capture therapy using microdosimetric kinetic model
Biomedical Physics & Engineering ExpressAbstract Objective . Proton boron capture therapy (PBCT) is a novel approach that utilizes alpha particles generated through the proton induced capture reaction with 11 B. Early studies reported substantial dose enhancements of 50%–96% near the Bragg peak,
Abdur Rahim +4 more
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LET‐based approximation of the microdosimetric kinetic model for proton radiotherapy
Medical PhysicsAbstractBackgroundPhenomenological relative biological effectiveness (RBE) models for proton therapy, based on the dose‐averaged linear energy transfer (LET), have been developed to address the apparent RBE increase towards the end of the proton range.
Alessio, Parisi +3 more
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VALIDATION OF THE MICRODOSIMETRIC KINETIC MODEL SOFTWARE MODULE
Proceedings of the International Conference NT+ME`26 (Gurzuf, from May 31 to June 7, 2026)A validation of the microdosimetric kinetic model (MKM) software module for cell survival prediction under carbon ion irradiation is presented; the module is implemented in C++ with a Python interface via pybind11 and supports CPU and GPU computation. Validation on 312 data points from the PIDE database yielded R² = 0.975 for stationary-phase cultures,
Aleksei Nikolaevich Solovev +2 more
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Physics in Medicine & Biology, 2020
Abstract To develop a Monte Carlo (MC)-based and robust ion beam therapy optimization system that separates the optimization algorithm from the relative biological effectiveness (RBE) modeling. Robustly optimized dose distributions were calculated and compared across three ion therapy beams (proton, helium, carbon)
Jiasen, Ma +5 more
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Abstract To develop a Monte Carlo (MC)-based and robust ion beam therapy optimization system that separates the optimization algorithm from the relative biological effectiveness (RBE) modeling. Robustly optimized dose distributions were calculated and compared across three ion therapy beams (proton, helium, carbon)
Jiasen, Ma +5 more
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Radiation Research, 2001
Hawkins, R. B. A Microdosimetric-Kinetic Model for the Sensitization of V79 Cells to Radiation by Incorporation of Bromodeoxyuridine. Radiat. Res. 155, 698-702 (2001). The sensitization of G(1)-phase V79 cells to killing by ionizing radiation through incorporation of bromodeoxyuridine (BrdU) in their DNA has been reported to occur exclusively through ...
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Hawkins, R. B. A Microdosimetric-Kinetic Model for the Sensitization of V79 Cells to Radiation by Incorporation of Bromodeoxyuridine. Radiat. Res. 155, 698-702 (2001). The sensitization of G(1)-phase V79 cells to killing by ionizing radiation through incorporation of bromodeoxyuridine (BrdU) in their DNA has been reported to occur exclusively through ...
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Radiation Research, 2018
An expression for the surviving fraction of a replicating population of cells exposed to permanently incorporated radionuclide is derived from the microdosimetric-kinetic model. It includes dependency on total implant dose, linear energy transfer (LET), decay rate of the radionuclide, the repair rate of potentially lethal lesions in DNA and the volume ...
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An expression for the surviving fraction of a replicating population of cells exposed to permanently incorporated radionuclide is derived from the microdosimetric-kinetic model. It includes dependency on total implant dose, linear energy transfer (LET), decay rate of the radionuclide, the repair rate of potentially lethal lesions in DNA and the volume ...
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