The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. [PDF]
PLoS Genetics, 2013 Microtubule-microfilament interactions are important for cytokinesis and subcellular localization of proteins and mRNAs. In the early zebrafish embryo, astral microtubule-microfilament interactions also facilitate a stereotypic segregation pattern of ...
Sreelaja Nair +5 more
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Villin: The major microfilament-associated protein of the intestinal microvillus [PDF]
Proceedings of the National Academy of Sciences, 1979 The major protein associated with actin in the microfilament core of intestinal microvilli has been purified. This protein, for which we propose the name villin, has a polypeptide molecular weight of approximately 95,000. Two arguments suggest that villin may be the microvillus crossfilament protein that links the microfilament core laterally down its ...
Anthony Bretscher, Klaus Weber
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Characterization of Human Palladin, a Microfilament-associated Protein [PDF]
Molecular Biology of the Cell, 2001 Actin-containing microfilaments control cell shape, adhesion, and contraction. In striated muscle, α-actinin and other Z-disk proteins coordinate the organization and functions of actin filaments. In smooth muscle and nonmuscle cells, periodic structures termed dense bodies and dense regions, respectively, are thought to serve functions analogous to Z ...
Olli-Matti Mykkänen +6 more
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The Roles of Microfilament-Associated Proteins, Drebrins, in Brain Morphogenesis: A Review [PDF]
Journal of Biochemistry, 1995 The cytoskeleton has been suggested to be one of the important endogenous factors that control neuronal morphogenesis. Analysis of the developmental changes in the protein composition of the brain led to the discovery of novel developmentally regulated actin-binding proteins, drebrins.
Tomoaki Shirao
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Suppression of Tumorigenicity in Breast Cancer Cells by the Microfilament Protein Profilin 1 [PDF]
The Journal of Experimental Medicine, 2000 Differential display screening was used to reveal differential gene expression between the tumorigenic breast cancer cell line CAL51 and nontumorigenic microcell hybrids obtained after transfer of human chromosome 17 into CAL51. The human profilin 1 (PFN1) gene was found overexpressed in the microcell hybrid clones compared with the parental line ...
Jürgen Janke +11 more
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) [PDF]
Frontiers in Plant ScienceThe microfilament cytoskeleton, formed by the process of actin polymerization, serves not only to support the morphology of the cell, but also to regulate a number of cellular activities.
Mengmeng Shi +12 more
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Basolateral Membrane-associated 27-kDa Heat Shock Protein and Microfilament Polymerization [PDF]
Journal of Biological Chemistry, 1997 The in vivo activity of the 27-kDa heat shock protein, a barbed-end microfilament capping protein, may be localized to the plasma membrane. To investigate this putative association, bovine endothelial cells expressing the human wild type or a mutant nonphosphorylatable 27-kDa heat shock protein were subjected to subcellular fractionation and immunoblot
Randolph S. Piotrowicz, Eugene G. Levin
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Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts [PDF]
Current Biology, 1997 The Drosophila central nervous system develops from stem cell like precursors called neuroblasts, which divide unequally to bud off a series of smaller daughter cells called ganglion mother cells. Neuroblasts show cell-cycle-specific asymmetric localization of both RNA and proteins: at late interphase, prospero RNA and Inscuteable, Prospero and Staufen
Julie Broadus, Chris Q. Doe
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Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments [PDF]
FEBS Letters, 1996 We have reported that purified native MAP1B interacts with microtubules but not with microfilaments [Pedrotti and Islam, Cell Motil. Cytoskel. (1995) 30, 301–309]. However, MAP1B can be phosphorylated at multiple sites by casein kinase II (CKII) and proline‐directed protein kinases (PDPK) and immunoblotting studies show that purified native MAP1B is ...
Barbara Pedrotti, Khalid Islam
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Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins [PDF]
The Journal of Cell Biology, 2001 By screening a yeast two-hybrid library with COOH-terminal fragments of vinculin/metavinculin as the bait, we identified a new protein termed raver1. Raver1 is an 80-kD multidomain protein and widely expressed but to varying amounts in different cell lines. In situ and in vitro, raver1 forms complexes with the microfilament-associated proteins vinculin,
Stefan Hüttelmaier +5 more
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