Results 91 to 100 of about 5,523,474 (277)
IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments [PDF]
The Journal of Cell Biology, 1997 Activated forms of the GTPases, Rac and Cdc42, are known to stimulate formation of microfilament-rich lamellipodia and filopodia, respectively, but the underlying mechanisms have remained obscure. We now report the purification and characterization of a protein, IQGAP1, which is likely to mediate effects of these GTPases on microfilaments.
Matthew J. Hart +3 more
openaire +2 more sources
Advanced Intelligent Systems, EarlyView.This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li +7 more
wiley +1 more source
A novel methodology on distributed representations of proteins using their interacting ligands [PDF]
Bioinformatics 2018, 2018 The effective representation of proteins is a crucial task that directly affects the performance of many bioinformatics problems. Related proteins usually bind to similar ligands. Chemical characteristics of ligands are known to capture the functional and mechanistic properties of proteins suggesting that a ligand based approach can be utilized in ...
arxiv +1 more source
RNA-binding protein conserved in both microtubule- and microfilament-based RNA localization [PDF]
Genes & Development, 1998 Vg1 mRNA translocation to the vegetal cortex ofXenopus oocytes requires intact microtubules, and a 3′ UTRcis-acting element (termed VLE), which also mediates sequence-specific binding of several proteins. One protein, the 69-kD Vg1 RBP, associates Vg1 RNA to microtubules in vitro.
Leora Havin +7 more
openaire +3 more sources
Animal Research and One Health, EarlyView.Mechanisms of light in regulating the chick pineal clock. Abstract The circadian clock significantly impacts animal health and productivity, with light playing a crucial role in regulating circadian rhythms. However, the mechanisms behind light‐induced circadian transmission remain unclear, particularly in light‐sensitive avian species.
Yunlei Li +10 more
wiley +1 more source
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. [PDF]
PLoS ONE, 2013 In a neonatal model of hypoxic pulmonary hypertension, a dramatic pulmonary artery adventitial thickening, accumulation of inflammatory cells in the adventitial compartment, and angiogenic expansion of the vasa vasorum microcirculatory network are ...
Siddaramappa Nagavedi Umapathy +7 more
doaj +1 more source
Interaction of rat liver lysosomal membranes with actin. [PDF]
, 1984 Membranes were prepared from lysosomes purified 80-fold by centrifugation in a discontinuous metrizamide gradient. When salt-washed membranes were combined with rabbit muscle actin, an increase in viscosity could be measured using a falling ball ...
Bame, KJ, Mehrabian, M, Rome, LH
core
Arthritis &Rheumatology, Accepted Article.Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava +9 more
wiley +1 more source
Changing of expression actinbinding proteins in the kidney under dehydration
Вавиловский журнал генетики и селекции, 2018 Actin is related to main structural proteins in eukaryotes. In opposite to muscle alpha-actin, beta-actin is expressing in all types of cells. The constant reorganization of actin cytoskeleton takes place in non-muscle cells.
I. I. Khegay
doaj +1 more source
Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer. [PDF]
, 2019 Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water.
Fang, Jia-Qi +7 more
core +1 more source