An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments [PDF]
Cell, 1996 Typified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments.
Yanmin Yang +5 more
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Differential Signaling Pathways Identified in Aqueous Humor, Anterior Capsule, and Crystalline Lens of Age-Related, Diabetic, and Post-Vitrectomy Cataract [PDF]
ProteomesBackground: The purpose of this study was to detect proteomic alterations and corresponding signaling pathways involved in the formation of age-related cataract (ARC), diabetic cataract (DC), and post-vitrectomy cataract (PVC).
Christina Karakosta +6 more
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Characterization of Syntenin, a Syndecan-binding PDZ Protein, as a Component of Cell Adhesion Sites and Microfilaments [PDF]
Molecular Biology of the Cell, 2001 Syntenin is a PDZ protein that binds the cytoplasmic C-terminal FYA motif of the syndecans. Syntenin is widely expressed. In cell fractionation experiments, syntenin partitions between the cytosol and microsomes. Immunofluorescence microscopy localizes endogenous and epitope-tagged syntenin to cell adhesion sites, microfilaments, and the nucleus ...
Pascale Zimmermann +8 more
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IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments [PDF]
The Journal of Cell Biology, 1997 Activated forms of the GTPases, Rac and Cdc42, are known to stimulate formation of microfilament-rich lamellipodia and filopodia, respectively, but the underlying mechanisms have remained obscure. We now report the purification and characterization of a protein, IQGAP1, which is likely to mediate effects of these GTPases on microfilaments.
Anne-Marie Bashour +3 more
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Gas2, a growth arrest-specific protein, is a component of the microfilament network system [PDF]
The Journal of cell biology, 1992 In this report we analyze the protein product of a growth arrest-specific gene, gas2, by means of an affinity-purified antibody raised against the protein produced in bacteria. The regulation of Gas2 biosynthesis reflects the pattern of mRNA expression (Schneider, C., R. King, and L. Philipson. 1988. Cell.
Claudio Brancolini +2 more
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Anticytoskeletal autoantibody to microfilament anchorage sites recognizes novel focal contact proteins. [PDF]
Journal of Clinical Investigation, 1987 Actin microfilaments are anchored to the plasma membrane at focal contacts. Using an indirect immunofluorescence method, we detected an autoantibody reactive with focal contacts in PtK2, HEp-2, and BHK-21 cells in serum from two patients with early systemic sclerosis. With double immunofluorescence, using the actin-binding drug phalloidin, we localized
Jean‐Luc Senécal +3 more
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Regulation of Apicomplexan Microfilament Dynamics by a Minimal Set of Actin‐Binding Proteins [PDF]
Traffic, 2006 Efficient and rapid host cell invasion is a prerequisite for an intracellular parasitic life style. Pathogens typically induce receptor‐mediated endocytosis and hijack the force‐transducing system of a host cell to gain access to a replication‐competent niche.
H. Schüler, Kai Matuschewski
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Observations Of Microfilament Bundles In Living Cells Microinjected With Fluorescently Labelled Contractile Proteins [PDF]
Journal of Cell Science, 1986 ABSTRACT Fluorescently labelled contractile proteins (alpha-actinin and filamin) were used to study the dynamic nature of three types of microfilament bundles: myofibrils, stress fibres and polygonal networks. Cultured muscle and non-muscle cells that were microinjected with fluorescent alphaactinin rapidly incorporated the labelled ...
Jean M. Sanger +3 more
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Temporal Profiling of Cellular and Molecular Processes in Osteodifferentiation of Dental Pulp Stem Cells [PDF]
BiologyBased on the potential of DPSCs as the most promising candidates for bone tissue engineering, we comprehensively investigated the time-dependent cellular and molecular changes that occur during their osteodifferentiation.
Bibiána Baďurová +8 more
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A marginal band-associated protein has properties of both microtubule- and microfilament-associated proteins. [PDF]
The Journal of cell biology, 1989 The marginal band of nucleated erythrocytes is a microtubule organelle under rigorous quantitative and spatial control, with properties quite different from those of the microtubule organelles of cultured cells. Previous results suggest that proteins other than tubulin may participate in organizing the marginal band, and may interact with elements of ...
Eric Birgbauer, F Solomon
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