Results 11 to 20 of about 16,157 (173)
Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7-Polarized Microfilament Coordination in Breast Cancer Cells. [PDF]
Adv Sci (Weinh)This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Zhu L +10 more
europepmc +2 more sources
The Significant Role of the Microfilament System in Tumors
Frontiers in Oncology, 2021 Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer and polymer. Among them, monomer actin is a spherical molecule composed of a polypeptide chain, also known as spherical actin.
Xin Jiang +6 more
doaj +1 more source
Villin: The major microfilament-associated protein of the intestinal microvillus [PDF]
Proceedings of the National Academy of Sciences, 1979 The major protein associated with actin in the microfilament core of intestinal microvilli has been purified. This protein, for which we propose the name villin, has a polypeptide molecular weight of approximately 95,000. Two arguments suggest that villin may be the microvillus crossfilament protein that links the microfilament core laterally down its ...
A, Bretscher, K, Weber
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Modulation of Microfilament Protein Composition by Transfected Cytoskeletal Actin Genes [PDF]
Molecular and Cellular Biology, 1988 HuT-14T is a highly tumorigenic fibroblast cell line which exhibits a reduced steady-state level of beta-actin due to coding mutations in one of two beta-actin alleles. The normal rate of total actin synthesis could be restored in some clones of cells following transfection of the functional beta-actin gene but not following transfection of the ...
S Y, Ng +4 more
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Scientific Reports, 2023 mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated.
Naphat Chantaravisoot +8 more
doaj +1 more source
Role of hypoxia in promoting migration and cell fusion of urine-derived stem cells
陆军军医大学学报, 2023 Objective To explore the effect of hypoxia on cell migration and fusion of urine-derived stem cells (USCs) in vitro, and observe the changes in cytoskeleton and cell polarity during the process.
ZHANG Nannan, HU Chaoqun, HE Yun
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An Essential Cytoskeletal Linker Protein Connecting Actin Microfilaments to Intermediate Filaments [PDF]
Cell, 1996 Typified by rapid degeneration of sensory neurons, dystonia musculorum mice have a defective BPAG1 gene, known to be expressed in epidermis. We report a neuronal splice form, BPAG1n, which localizes to sensory axons. Both isoforms have a coiled-coil rod, followed by a carboxy domain that associates with intermediate filaments.
Yang, Y. +5 more
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Molecular imaging of membrane proteins and microfilaments using atomic force microscopy [PDF]
Experimental and Molecular Medicine, 2010 Atomic force microscopy (AFM) is an emerging technique for a variety of uses involving the analysis of cells. AFM is widely applied to obtain information about both cellular structural and subcellular events. In particular, a variety of investigations into membrane proteins and microfilaments were performed with AFM.
Se-Hui, Jung +4 more
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Asian Journal of Andrology, 2016 Plastins are a family of actin binding proteins (ABPs) known to cross-link actin microfilaments in mammalian cells, creating actin microfilament bundles necessary to confer cell polarity and cell shape.
Nan Li, Chris KC Wong, C Yan Cheng
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LIM Kinases in Osteosarcoma Development
Cells, 2021 Tumorigenesis is a long-term and multistage process that often leads to the formation of metastases. During this pathological course, two major events appear to be crucial: primary tumour growth and metastatic expansion. In this context, despite research
Régis Brion +5 more
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