Results 51 to 60 of about 16,157 (173)

Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression

Marine Drugs, 2018
Heteronemin, the most abundant secondary metabolite in the sponge Hippospongia sp., exhibited potent cytotoxic activity against several cancer cell lines.
Yu-Cheng Chen, Mei-Chin Lu, Mohamed El-Shazly, Kuei-Hung Lai, Tung-Ying Wu, Yu-Ming Hsu, Yi-Lun Lee, Yi-Chang Liu   +7 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Dynamic changes and transcriptome analyses reveal the microfilament skeleton response to water stress in thalli of Neopyropia yezoensis inhabiting the intertidal zone

Plant Stress
The microfilament (MF) cytoskeleton, present in all eukaryotic cells, is not only essential for fundamental cellular processes but also is important in sensing and transducing external signals in response to various developmental cues and abiotic ...
Jiqiang Yin, Ying Sun, Xinping Miao, Jiaxin Qu, Kunjie Zhang, Xue qing Han, Yichi Li, Jiahui Sun, Fanna Kong   +8 more
doaj   +1 more source

miR‐185‐5p Derived From hUC‐MSC Exosomes via Suspension Culture Under Hypoxic Conditions Promotes Scarless Wound Healing in Mice by Precisely Regulating Collagen I/III Regeneration

Advanced Science, EarlyView.
miR‐185‐5p derived from UC‐MSC exosomes via hypoxic suspension culture promotes scarless wound healing in mice by precisely regulating collagen I/III regeneration. Exosomes derived from UC‐MSCs under a three‐dimensional bioreactor and hypoxic conditions were injected into the skin wounds of mice.
Lihua Yang, Yiqun Sun, Qinbiao Yan, Ali Mohsin, Kamran Ashraf, Senyi Gong, Weifeng Li, Touseef Ur Rehman, Yuwen Hu, Jinzhao He, Yu Liu, Meijun Ding, Lin Qi, Meijin Guo, Ke Xue   +14 more
wiley   +1 more source

Proteomic Analysis of the Effect of Proteasome on Quality Changes in Qinchuan Beef during Postmortem Storage [PDF]

Shipin Kexue
In this study, the Longissimus dorsi muscle of Qinchuan beef stored at 4 ℃ after slaughter was determined for its quality indicators, energy level and proteasome activity.
HU Lijun, WANG Jinxia, LI Rong, ZHANG Qian, CHEN Xueyan, LI Yalei, LUO Ruiming
doaj   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

IQGAP1, a Rac- and Cdc42-binding Protein, Directly Binds and Cross-links Microfilaments [PDF]

The Journal of Cell Biology, 1997
Activated forms of the GTPases, Rac and Cdc42, are known to stimulate formation of microfilament-rich lamellipodia and filopodia, respectively, but the underlying mechanisms have remained obscure. We now report the purification and characterization of a protein, IQGAP1, which is likely to mediate effects of these GTPases on microfilaments.
A M, Bashour, A T, Fullerton, M J, Hart, G S, Bloom   +3 more
openaire   +2 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Microfilament dynamics during cell movement and chemotaxis monitored using a GFP–actin fusion protein [PDF]

Current Biology, 1997
The microfilament system in the cortex of highly motile cells, such as neutrophils and cells of the eukaryotic microorganism Dictyostelium discoideum, is subject to rapid re-organization, both spontaneously and in response to external signals. In particular, actin polymerization induced by a gradient of chemoattractant leads to local accumulation of ...
Westphal, Monika, Jungbluth, Andreas, Heidecker, Manfred, Mühlbauer, Bettina, Heizer, Christina, Schwartz, Jean Marc, Marriott, Gerard, Gerisch, Günther   +7 more
openaire   +3 more sources

Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. [PDF]

PLoS ONE, 2013
In a neonatal model of hypoxic pulmonary hypertension, a dramatic pulmonary artery adventitial thickening, accumulation of inflammatory cells in the adventitial compartment, and angiogenic expansion of the vasa vasorum microcirculatory network are ...
Siddaramappa Nagavedi Umapathy, Elzbieta Kaczmarek, Nooreen Fatteh, Nana Burns, Rudolf Lucas, Kurt R Stenmark, Alexander D Verin, Evgenia V Gerasimovskaya   +7 more
doaj   +1 more source