Results 1 to 10 of about 266,602 (329)
Physiological Reviews, 2011 Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed “resting microglia.” Recent studies indicate that even in the normal ...
Helmut, Kettenmann +3 more
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Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Brain region- and sex-specific transcriptional profiles of microglia
Frontiers in Psychiatry, 2022 Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko +15 more
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Cellular and Molecular Life Sciences, 2023 AbstractMicroglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated.
Ignazio Antignano +3 more
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In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity
Frontiers in Immunology, 2022 Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage.
Julian Wolf +10 more
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Efficient Strategies for Microglia Replacement in the Central Nervous System
Cell Reports, 2020 Summary: Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases.
Zhen Xu +13 more
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Journal of Neuroinflammation, 2022 Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized.
Olus Uyar +8 more
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Frontiers in Immunology, 2022 Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity and
Shuailong Li +6 more
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IBRO Neuroscience Reports, 2021 Morphological and functional characterizations of cultured microglia are essential for the improved understanding of their roles in neuronal health and disease.
Karolina Dulka +3 more
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Detection of Synaptic Proteins in Microglia by Flow Cytometry
Frontiers in Molecular Neuroscience, 2020 A growing body of evidence indicates that microglia actively remove synapses in vivo, thereby playing a key role in synaptic refinement and modulation of brain connectivity.
Simone Brioschi +12 more
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