Results 1 to 10 of about 385,875 (341)
Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao +3 more
semanticscholar +1 more source
Microglia Mediated Neuroinflammation in Parkinson’s Disease
Cells, 2023 Parkinson’s Disease (PD) is the second most common neurodegenerative disorder seen, especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance and coordination are among the hallmarks, and dopaminergic neuronal loss in ...
Sevim Isik +4 more
semanticscholar +1 more source
Brain region- and sex-specific transcriptional profiles of microglia
Frontiers in Psychiatry, 2022 Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko +15 more
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In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity
Frontiers in Immunology, 2022 Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage.
Julian Wolf +10 more
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Efficient Strategies for Microglia Replacement in the Central Nervous System
Cell Reports, 2020 Summary: Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases.
Zhen Xu +13 more
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Journal of Neuroinflammation, 2022 Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized.
Olus Uyar +8 more
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Frontiers in Immunology, 2022 Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity and
Shuailong Li +6 more
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Frontiers in Immunology, 2023 Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms of IS.
Jinsong Zeng +8 more
semanticscholar +1 more source
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
semanticscholar +1 more source