Results 1 to 10 of about 225,547 (369)
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2022 Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Yafu Yin
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Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Frontiers in Cellular Neuroscience, 2020 Inflammatory processes and microglia activation accompany most of the pathophysiological diseases in the central nervous system. It is proven that glial pathology precedes and even drives the development of multiple neurodegenerative conditions.
Agnieszka M Jurga, Katarzyna Z Kuter
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Microglia Function in the Central Nervous System During Health and Neurodegeneration
Annual Review of Immunology, 2017 Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic ...
Marco Colonna, Oleg Butovsky, Bing Xie
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Interaction of Microglia and Astrocytes in the Neurovascular Unit
Frontiers in Immunology, 2020 The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults.
Lirong Liu +4 more
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Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB [PDF]
Molecular NeurodegenerationBackground Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated in contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Benjamin E. Clarke +11 more
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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Cell, 2017 Hadas Keren-shaul +2 more
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Negative feedback control of neuronal activity by microglia
Nature, 2020 Aditya Nair, Ana Badimon, Anat Kahan
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Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Brain region- and sex-specific transcriptional profiles of microglia
Frontiers in Psychiatry, 2022 Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko +15 more
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