Results 1 to 10 of about 316,864 (309)
Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi +14 more
core +9 more sources
Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
doaj +1 more source
In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity
Frontiers in Immunology, 2022 Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage.
Julian Wolf +10 more
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Brain region- and sex-specific transcriptional profiles of microglia
Frontiers in Psychiatry, 2022 Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko +15 more
doaj +1 more source
Physiological Reviews, 2011 Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed “resting microglia.” Recent studies indicate that even in the normal ...
Helmut, Kettenmann +3 more
openaire +2 more sources
Efficient Strategies for Microglia Replacement in the Central Nervous System
Cell Reports, 2020 Summary: Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases.
Zhen Xu +13 more
doaj +1 more source
Journal of Neuroinflammation, 2022 Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized.
Olus Uyar +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity and
Shuailong Li +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of melatonin are of relevance in terms of antioxidative protection, not only concerning free-radical detoxification, but also in prevention of processes that cause, promote, or propagate oxidative stress
Hardeland, Rüdiger +1 more
openaire +3 more sources
IBRO Neuroscience Reports, 2021 Morphological and functional characterizations of cultured microglia are essential for the improved understanding of their roles in neuronal health and disease.
Karolina Dulka +3 more
doaj +1 more source