Results 1 to 10 of about 379,641 (387)

Glial Purinergic Signaling in Neurodegeneration

Frontiers in Neurology, 2021
Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski, Amr Ahmed Gabr, Amr Ahmed Gabr, Stanislav Kozlov, David Blum, David Blum, Annett Halle, Annett Halle, Kevin Carvalho, Kevin Carvalho   +9 more
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In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity

Frontiers in Immunology, 2022
Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage.
Julian Wolf, Stefaniya Boneva, Dennis-Dominik Rosmus, Hansjürgen Agostini, Günther Schlunck, Peter Wieghofer, Peter Wieghofer, Anja Schlecht, Anja Schlecht, Clemens Lange, Clemens Lange   +10 more
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Brain region- and sex-specific transcriptional profiles of microglia

Frontiers in Psychiatry, 2022
Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Yvette Afriyie-Agyemang, Stephanie Puig, Stephanie Puig, Zachary Freyberg, Zachary Freyberg, Zachary Freyberg, George C. Tseng, Ryan W. Logan, Ryan W. Logan, Ryan W. Logan, Marianne L. Seney, Marianne L. Seney   +15 more
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Efficient Strategies for Microglia Replacement in the Central Nervous System

Cell Reports, 2020
Summary: Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases.
Zhen Xu, Yanxia Rao, Yubin Huang, Tian Zhou, Rui Feng, Shanshan Xiong, Ti-Fei Yuan, Shan Qin, Yijie Lu, Xin Zhou, Xiaoyu Li, Bo Qin, Ying Mao, Bo Peng   +13 more
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Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

Journal of Neuroinflammation, 2022
Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized.
Olus Uyar, Juan Manuel Dominguez, Maude Bordeleau, Lina Lapeyre, Fernando González Ibáñez, Luc Vallières, Marie-Eve Tremblay, Jacques Corbeil, Guy Boivin   +8 more
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Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity

Frontiers in Immunology, 2022
Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity and
Shuailong Li, Isa Wernersbach, Gregory S. Harms, Gregory S. Harms, Michael K. E. Schäfer, Michael K. E. Schäfer, Michael K. E. Schäfer   +6 more
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Detection of Synaptic Proteins in Microglia by Flow Cytometry

Frontiers in Molecular Neuroscience, 2020
A growing body of evidence indicates that microglia actively remove synapses in vivo, thereby playing a key role in synaptic refinement and modulation of brain connectivity.
Simone Brioschi, Simone Brioschi, Paolo d’Errico, Lukas S. Amann, Lukas S. Amann, Hana Janova, Sonja M. Wojcik, Melanie Meyer-Luehmann, Lawrence Rajendran, Peter Wieghofer, Rosa C. Paolicelli, Rosa C. Paolicelli, Knut Biber   +12 more
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Quantitative morphometric and cell-type-specific population analysis of microglia-enriched cultures subcloned to high purity from newborn rat brains

IBRO Neuroscience Reports, 2021
Morphological and functional characterizations of cultured microglia are essential for the improved understanding of their roles in neuronal health and disease.
Karolina Dulka, Kálmán Nacsa, Noémi Lajkó, Karoly Gulya   +3 more
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Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
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Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]

, 2020
Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie, de Vries, Helga E., Franssen, Marc, Kamermans, Alwin, Popovic, Marko, Roucourt, Bart, Schouten, Marijn, Sobrino, Tomás, van der Pol, Susanne M.A., van Olst, Lynn, Vandenbroucke, Roosmarijn, Verhaege, Daan, Wever, Dennis, Ytebrouck, Ellen   +13 more
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