Results 1 to 10 of about 242,823 (354)
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2022 Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Yafu Yin
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Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals [PDF]
eLifeMicroglia are brain-resident macrophages playing pivotal roles in central nervous system (CNS) development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance remains largely unknown.
Yi Wu +8 more
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Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Frontiers in Cellular Neuroscience, 2020 Inflammatory processes and microglia activation accompany most of the pathophysiological diseases in the central nervous system. It is proven that glial pathology precedes and even drives the development of multiple neurodegenerative conditions.
Agnieszka M Jurga, Katarzyna Z Kuter
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Negative feedback control of neuronal activity by microglia
Nature, 2020 Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival 1 .
Aditya Nair, Ana Badimon, Anat Kahan
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Microglia Function in the Central Nervous System During Health and Neurodegeneration
Annual Review of Immunology, 2017 Microglia are resident cells of the brain that regulate brain development, maintenance of neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct from other tissue macrophages owing to their unique homeostatic ...
Marco Colonna, Oleg Butovsky, Bing Xie
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Interaction of Microglia and Astrocytes in the Neurovascular Unit
Frontiers in Immunology, 2020 The interaction between microglia and astrocytes significantly influences neuroinflammation. Microglia/astrocytes, part of the neurovascular unit (NVU), are activated by various brain insults.
Lirong Liu +4 more
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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Cell, 2017 Hadas Keren-shaul +2 more
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Glial Purinergic Signaling in Neurodegeneration
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
doaj +1 more source
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao +3 more
semanticscholar +1 more source