Results 1 to 10 of about 239,720 (224)

Downregulation of PIK3IP1 in retinal microglia promotes retinal pathological neovascularization via PI3K-AKT pathway activation

Scientific Reports, 2023
Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen, Yuan Cao, Yaming Shen, Huan Li, Rong Ye, Jin Yao   +5 more
doaj   +1 more source

The potential of Antheraea pernyi silk for spinal cord repair [PDF]

, 2017
This work was supported by the Institute of Medical Sciences of the University of Aberdeen, Scottish Rugby Union and RS McDonald Charitable Trust. We are grateful to Mr Nicholas Hawkins from Oxford University and Ms Annette Raffan from the University of ...
Huang, W, Knight, D, Lesage, S, Rajnicek, A M, Varone, A, Vollrath, F   +5 more
core   +2 more sources

Adaptive Müller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina

Journal of Neuroinflammation, 2011
Purpose Microglia and Müller cells are prominent participants in retinal responses to injury and disease that shape eventual tissue adaptation or damage.
Wang Minhua, Ma Wenxin, Zhao Lian, Fariss Robert N, Wong Wai T   +4 more
doaj   +1 more source

Negative feedback control of neuronal activity by microglia

Nature, 2020
Microglia, the brain’s resident macrophages, help to regulate brain function by removing dying neurons, pruning non-functional synapses, and producing ligands that support neuronal survival 1 .
Ana Badimon, Hayley J Strasburger, Pinar Ayata, Xinhong Chen, Aditya Nair, Ako Ikegami, Philip Hwang, Andrew T. Chan, Steven M. Graves, Joseph O. Uweru, Carola Ledderose, M. Kutlu, Michael A. Wheeler, A. Kahan, Masago Ishikawa, Ying-Chih Wang, Y. Loh, Jean X. Jiang, D. Surmeier, S. Robson, W. Junger, R. Sebra, E. Calipari, P. Kenny, Ukpong B. Eyo, M. Colonna, F. Quintana, H. Wake, V. Gradinaru, A. Schaefer   +29 more
semanticscholar   +1 more source

Microglia and neuroprotection [PDF]

Journal of Neurochemistry, 2015
AbstractMicroglia were first identified over a century ago, but our knowledge about their ontogeny and functions has significantly expanded only recently. Microglia colonize the central nervous system (CNS) in utero and play essential roles in brain development.
Zhihong Chen, Bruce D. Trapp
openaire   +2 more sources

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L, Duke, Laura, Johnson, Jo Anne, Kodavanti, Prasada, Kodavanti, Urmila, Levesque, Shannon, Lull, Melinda E., Stadler, Krisztian, Surace, Michael J., Taetzsch, Thomas, Wagner, Alison   +10 more
core   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Physalis alkekengi L. var. francheti alleviates neuronal cell death caused by activated microglia in vitro [PDF]

, 2021
Byoung Hee Park, Oh Wook Kwon, In Sung Kim, Hae Min Lee, Yeon Jin Roh, Minseo Kim, Youngho Jo, Hwayeon Cho, Jung Kuk Park, Zhi Zheng, Byung Cheon Lee   +10 more
openalex   +1 more source

Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

Nature Communications, 2020
The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type.
M. Olah, V. Menon, Naomi Habib, M. Taga, Yiyi Ma, Christina Yung, M. Cimpean, Anthony Khairallah, G. Coronas-Samano, R. Sankowski, Dominic Grün, Alexandra Kroshilina, Danielle Dionne, R. Sarkis, G. Cosgrove, Jeffrey J. Helgager, J. Golden, P. Pennell, M. Prinz, J. Vonsattel, A. Teich, J. Schneider, D. Bennett, A. Regev, W. Elyaman, E. Bradshaw, P. D. De Jager   +26 more
semanticscholar   +1 more source

Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy [PDF]

, 2008
The role of heterotopic (migratory) motoneurons (HMN) in the pathogenesis of spinal muscular atrophy (SMA) is still controversial. We examined the occurrence and amount of HMN in spinal cord tissue from eight children with SMA (six with SMA-I and two ...
Barišić, Nina, Hof, Patrick R., Islam, Atiqul, Jovanov Milošević, Nataša, Krušlin, Božo, Lucassen, Paul J., Mladinov, Mihovil, Pajtak, Alen, Sertić, Jadranka, Šešo Šimić, Đurđica, Šimić, Goran   +10 more
core   +1 more source