Results 1 to 10 of about 129,419 (228)

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi   +14 more
core   +10 more sources

Melatonin and Microglia [PDF]

open access: yesInternational Journal of Molecular Sciences, 2021
Melatonin interacts in multiple ways with microglia, both directly and, via routes of crosstalk with astrocytes and neurons, indirectly. These effects of melatonin are of relevance in terms of antioxidative protection, not only concerning free-radical detoxification, but also in prevention of processes that cause, promote, or propagate oxidative stress
Hardeland, Rüdiger   +1 more
openaire   +3 more sources

Glial Purinergic Signaling in Neurodegeneration

open access: yesFrontiers in Neurology, 2021
Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski   +9 more
doaj   +1 more source

Microglia and Microglia-Like Cells: Similar but Different [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2022
Microglia are the tissue-resident macrophages of the central nervous parenchyma. In mammals, microglia are thought to originate from yolk sac precursors and posteriorly maintained through the entire life of the organism. However, the contribution of microglial cells from other sources should also be considered.
Cuadros Ojeda, Miguel Ángel   +4 more
openaire   +4 more sources

Brain region- and sex-specific transcriptional profiles of microglia

open access: yesFrontiers in Psychiatry, 2022
Microglia are resident macrophages of the brain, performing roles related to brain homeostasis, including modulation of synapses, trophic support, phagocytosis of apoptotic cells and debris, as well as brain protection and repair.
Kelly Barko   +15 more
doaj   +1 more source

Aging microglia

open access: yesCellular and Molecular Life Sciences, 2023
AbstractMicroglia are the tissue-resident macrophage population of the brain, specialized in supporting the CNS environment and protecting it from endogenous and exogenous insults. Nonetheless, their function declines with age, in ways that remain to be fully elucidated.
Ignazio Antignano   +3 more
openaire   +2 more sources

In-Depth Molecular Profiling Specifies Human Retinal Microglia Identity

open access: yesFrontiers in Immunology, 2022
Microglia are the tissue-resident macrophages of the retina and brain, being critically involved in organ development, tissue homeostasis, and response to cellular damage.
Julian Wolf   +10 more
doaj   +1 more source

Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response

open access: yesJournal of Neuroinflammation, 2022
Background Microglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes simplex encephalitis (HSE) has not been fully characterized.
Olus Uyar   +8 more
doaj   +1 more source

Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity

open access: yesFrontiers in Immunology, 2022
Microglia are phagocytosis-competent CNS cells comprising a spectrum of subtypes with beneficial and/or detrimental functions in acute and chronic neurodegenerative disorders. The heterogeneity of microglia suggests differences in phagocytic activity and
Shuailong Li   +6 more
doaj   +1 more source

Physiology of Microglia [PDF]

open access: yesPhysiological Reviews, 2011
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed “resting microglia.” Recent studies indicate that even in the normal ...
Helmut, Kettenmann   +3 more
openaire   +3 more sources

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