Results 31 to 40 of about 266,602 (329)
Microglia actively regulate the number of functional synapses. [PDF]
PLoS ONE, 2013 Microglia are the immunocompetent cells of the central nervous system. In the physiological setting, their highly motile processes continually survey the local brain parenchyma and transiently contact synaptic elements.
Kyungmin Ji +3 more
doaj +1 more source
STAR Protocols, 2021 Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj +1 more source
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration
Nature Neuroscience, 2022 Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and ...
Sean K. Ryan +22 more
semanticscholar +1 more source
A richer and more diverse future for microglia phenotypes
Heliyon, 2023 Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
doaj +1 more source
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Frontiers in Cellular Neuroscience, 2020 Inflammatory processes and microglia activation accompany most of the pathophysiological diseases in the central nervous system. It is proven that glial pathology precedes and even drives the development of multiple neurodegenerative conditions.
A. Jurga, Martyna Paleczna, K. Kuter
semanticscholar +1 more source
Journal of Inflammation Research, 2022 Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities.
Menglong Wang +5 more
semanticscholar +1 more source
Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain
STAR Protocols, 2021 Summary: Mutations in microglia may cause brain disorders. Replacement of dysfunctional microglia by allogeneic wild-type microglia from bone marrow transplantation (Mr BMT) or peripheral blood can correct the gene deficiency at the brain-wide scale but ...
Zhen Xu, Bo Peng, Yanxia Rao
doaj +1 more source
Cell Reports, 2013 Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu +11 more
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Tools and Approaches for Studying Microglia In vivo
Frontiers in Immunology, 2020 Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan +2 more
doaj +1 more source