Results 31 to 40 of about 311,522 (275)

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

Cell Reports, 2013
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu, Emiko T.A. Morimoto, Hani Goodarzi, Jennifer T. Liao, Sean O’Keeffe, Hemali P. Phatnani, Michael Muratet, Michael C. Carroll, Shawn Levy, Saeed Tavazoie, Richard M. Myers, Tom Maniatis   +11 more
doaj   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A [PDF]

, 2017
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves hepatic production of acute-phase proteins, including serum amyloid A (SAA). Extrahepatically, SAA immunoreactivity is found in axonal myelin sheaths of cortex
A Castellheim, A Ellis, AE Mullick, BK Lundholt, BM Schreiber, C Caltagirone, C Gabay, C Marinelli, C Nathan, C Nuccio De, C Rosin, C Solà, C Vaure, CM Uhlar, DB Noriega, DL Thiele, E Gruys, ES Wohleb, F Begum, F Caso, G Guillemin, GC Sellar, GS Getz, GW Duff, H Zheng, HJ Yu, I Hardardóttir, I Paterniti, I Paterniti, I Rajkovic, J Saura, JM Dopp, JS Liang, JT Guo, JW Jeong, J‐L Tchélingérian, K Selmaj, L Facci, L Probert, L Qin, L Sun, M Alhouayek, M Barbierato, M Bsibsi, M Buck De, M Cordaro, M Kopf, M Li, M Poljakovic, ME Hamby, MK McCoy, MS Kindy, N Castanon, N Cheng, N Marchi, P Matzinger, R Martini, RA Dal Canto, RL Meek, RM Ransohoff, S Amor, S Kim, S Lehnardt, S Sandri, S Spuler, SA Liddelow, SD Skaper, SD Skaper, SJ Crocker, SJ Hewett, SY Seong, T Kawamoto, T Miida, TC Theoharides, TF Chung, Y Kumon, Y Yu, YJ Jang   +77 more
core   +3 more sources

Microglia replacement by microglia transplantation (Mr MT) in the adult mouse brain

STAR Protocols, 2021
Summary: Mutations in microglia may cause brain disorders. Replacement of dysfunctional microglia by allogeneic wild-type microglia from bone marrow transplantation (Mr BMT) or peripheral blood can correct the gene deficiency at the brain-wide scale but ...
Zhen Xu, Bo Peng, Yanxia Rao
doaj   +1 more source

Microglia [PDF]

Current Biology, 2008
Soulet, Denis, Rivest, Serge
  +6 more sources

Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

STAR Protocols, 2021
Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj   +1 more source

Microglia from neurogenic and non-neurogenic regions display differential proliferative potential and neuroblast support

Frontiers in Cellular Neuroscience, 2014
Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions.
Gregory Paul Marshall, Loic P Deleyrolle, Brent A Reynolds, Dennis A Steindler, Eric D Laywell   +4 more
doaj   +1 more source

A richer and more diverse future for microglia phenotypes

Heliyon, 2023
Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
doaj   +1 more source

EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]

, 2019
Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe, Chen, David, Feng, Xi, Gupta, Nalin, Gupta, Sonali, Liu, Sharon, Rosi, Susanna   +6 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source