Results 41 to 50 of about 242,823 (354)
Microglia regulation of synaptic plasticity and learning and memory
Neural Regeneration Research, 2021 Microglia are the resident macrophages of the central nervous system. Microglia possess varied morphologies and functions. Under normal physiological conditions, microglia mainly exist in a resting state and constantly monitor their microenvironment and ...
J. Cornell +3 more
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Cell Reports, 2013 Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu +11 more
doaj +1 more source
Microglia in Parkinson’s Disease
Journal of Parkinson's Disease, 2022 Microglia are the primary resident immune cells of the central nervous system. Neuropathological reports have identified augmented microglial activation in brains of patients with neurodegenerative disorders including Parkinson’s disease (PD).
N. Stefanova
semanticscholar +1 more source
Microglia-Derived Microvesicles Affect Microglia Phenotype in Glioma [PDF]
Frontiers in Cellular Neuroscience, 2019 Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids. In the nervous system, EVs participate to neuron-glial cross-talk, a bidirectional communication important to ...
Alfonso Grimaldi +14 more
openaire +6 more sources
Microglia morphophysiological diversity and its implications for the CNS
Frontiers in Immunology, 2022 Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development.
A. Vidal-Itriago +9 more
semanticscholar +1 more source
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Cells, 2022 Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the
Menbere Y Wendimu, S. Hooks
semanticscholar +1 more source
Efficient Strategies for Microglia Replacement in the Central Nervous System
Cell Reports, 2020 Summary: Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases.
Zhen Xu +13 more
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Frontiers in Cellular Neuroscience, 2014 Microglia isolated from the neurogenic subependymal zone (SEZ) and hippocampus (HC) are capable of massive in vitro population expansion that is not possible with microglia isolated from non-neurogenic regions.
Gregory Paul Marshall +4 more
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Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function
Biology, 2021 Microglia act as the immune cells of the central nervous system (CNS). They play an important role in maintaining brain homeostasis but also in mediating neuroimmune responses to insult.
Hui Peng +3 more
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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Nature Neuroscience, 2022 Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbations ...
Nina M. Dräger +18 more
semanticscholar +1 more source