Results 41 to 50 of about 266,602 (329)
APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
NatureSeveral genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1.
Michael Haney +27 more
semanticscholar +1 more source
Microglia use TAM receptors to detect and engulf amyloid beta plaques
Nature Immunology, 2021 Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally.
Youtong Huang +7 more
semanticscholar +1 more source
New insight on microglia activation in neurodegenerative diseases and therapeutics
Frontiers in Neuroscience, 2023 Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu +6 more
doaj +1 more source
Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue
Biomolecules, 2022 Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff +3 more
doaj +1 more source
Frontiers in Neurology, 2023 Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of microglia, and we now ...
Jun Qin, Zhihui Ma, Xiaoli Chen, S. Shu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
An updated assessment of microglia depletion: current concepts and future directions
Molecular Brain, 2017 Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly
Jinming Han +2 more
doaj +1 more source
Rod microglia: a morphological definition. [PDF]
PLoS ONE, 2014 Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor +3 more
doaj +1 more source
Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids
Scientific Reports, 2023 Microglia play a vital role maintaining brain homeostasis but can also cause persistent neuroinflammation. Short-chain fatty acids (SCFAs) produced by the intestinal microbiota have been suggested to regulate microglia inflammation indirectly by ...
M. Caetano-Silva +5 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source