Results 41 to 50 of about 388,044 (340)

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, 2021
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
semanticscholar   +1 more source

Rod microglia: a morphological definition. [PDF]

PLoS ONE, 2014
Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor, Cristina Morganti-Kossmann, Jonathan Lifshitz, Jenna M Ziebell   +3 more
doaj   +1 more source

Modulation of adult-born neurons in the inflamed hippocampus. [PDF]

, 2013
Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core   +2 more sources

Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

Frontiers in Neuroscience, 2021
Microglia are the resident macrophages of the central nervous system (CNS) acting as the first line of defense in the brain by phagocytosing harmful pathogens and cellular debris. Microglia emerge from early erythromyeloid progenitors of the yolk sac and
L. Muzio, Alice Viotti, G. Martino
semanticscholar   +1 more source

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling [PDF]

, 2014
Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process.
Alvarez-Buylla, Alvaro, Ana I. Santos, Ana S. Lourenço, António F. Ambrósio, Arvidsson, Bal-Price, Batchelor, Beckman, Beltran, Ben-Hur, Benraiss, Bergsland, Boje, Bruno P. Carreira, Buck, Butovsky, Cacci, Caetana M. Carvalho, Calabrese, Calabrese, Cappella, Carreira, Carreira, Chao, Chehrehasa, Covacu, Curtis, Davalos, Dawson, Dawson, Doetsch, Ekdahl, Ekdahl, Eriksson, Estrada, Gage, Galea, Giulian, Green, Guix, Hanafy, Ignarro, Inês M. Araújo, Iosif, Ischiropoulos, Keefer, Kempermann, Kettenmann, Keynes, Lane, Lowenstein, Madhusoodanan, Maria I. Morte, Matarredona, Ming, Misko, Moncada, Monje, Monje, Monteiro, Moreno-Lopez, Murillo-Carretero, Murillo-Carretero, Murphy, Nathan, Nimmerjahn, Ormerod, Packer, Parent, Pryor, Radi, Reynolds, Rock, Salvemini, Saura, Sierra, Szabo, Taupin, Torroglosa, Uc, Vallieres, Walton, Zhang, Zhang, Zhang   +85 more
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Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

STAR Protocols, 2021
Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating ...
Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
doaj   +1 more source

Microglia use TAM receptors to detect and engulf amyloid beta plaques

Nature Immunology, 2021
Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally.
Youtong Huang, Kaisa E Happonen, P. Burrola, Carolyn O’Connor, N. Hah, Ling Huang, A. Nimmerjahn, G. Lemke   +7 more
semanticscholar   +1 more source

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

Cell Reports, 2013
Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo ...
Isaac M. Chiu, Emiko T.A. Morimoto, Hani Goodarzi, Jennifer T. Liao, Sean O’Keeffe, Hemali P. Phatnani, Michael Muratet, Michael C. Carroll, Shawn Levy, Saeed Tavazoie, Richard M. Myers, Tom Maniatis   +11 more
doaj   +1 more source

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons [PDF]

, 2017
The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders.
Alhouayek M, Amor S, Amor S, Appel SH, Bankston AN, Biber K, Biran V, Borsook D, Brenner T, Brooks TA, Buchanan MM, Bulanova E, Burnstock G, Calcia MA, Castellheim A, Chan-Ling T, Chen YJ, Choudhuri K, Christophi GP, Christy AL, Compston A, Conti P, Corrigan F, Cristino L, Cunningham C, Dirckx M, Donath MY, Done JD, D’Agostino G, Eckenhoff RG, Eggen BJ, Ellis A, Engler H, Ertürk A, Eskander MA, Esposito P, Fonken LK, Forsythe P, Freeman LC, Fullerton JN, Gao YJ, Gaudenzio N, Geppetti P, Grace PM, Grakoui A, Gregory GD, Griffin RS, Guerreiro R, Gunin AG, Hagiyama M, Hains LE, Hanisch UK, Harcha PA, Harvey GK, Hayashi R, Heneka MT, Hickman SE, Hsieh CL, Hu W, Héron A, Iadecola C, Ito A, Jay GW, Jensen TS, Ji RR, Jin Y, Jin Y, Juremalm M, Kajihara Y, Kalesnikoff J, Kalichman MW, Kamm CP, Kerstman E, Kobayashi K, Kolbinger F, Koshinaga M, Kwon C, Lange C, Lapilover EG, Laura Facci, Le Thuc O, Leon A, Levy D, Li M, Li X, Liew FY, Lozada A, Lull ME, Luongo L, Manocha GD, Marchi N, Martini R, Maslinska D, Mate I, Matsuda H, Mattila OS, McGeer PL, Medeiros R, Medic N, Medic N, Michaloudi H, Michaud M, Millan MJ, Miller G, Milligan ED, Monks CR, Morena Zusso, Myers RR, Nakae S, Nakajima A, Nathan C, Nave KA, Nelissen S, Nguyen M, Norden DM, Noriega DB, Old EA, Orr AG, Osipchuk Y, Osterberg A, Park CK, Parvathenani LK, Patti GJ, Peferoen L, Peferoen LA, Pekny M, Pelisch N, Perry VH, Perry VH, Pietro Giusti, Prinz M, Prussin C, Punzo D, Ramlackhansingh AF, Ransohoff RM, Rapp JH, Rawji KS, Riedel B, Rivat C, Rosa AC, Sakamoto A, Sastre M, Sayed BA, Silver R, Silverman AJ, Sivanandam TM, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skuljec J, Smith BH, Smith JA, Sospedra M, Stephen D. Skaper, Streit WJ, Suurmond J, Terrando N, Thacker MA, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Ulmann L, van Hecke O, Varma R, von Büdingen HC, Vyas H, Wang M, Wang Y, Wardlaw AJ, Watkins LR, Wohleb ES, Xie F, Young KM, Yuan H, Zarpelon AC, Zeis T, Zhang H, Zhang S, Zhang ZG, Zuo Y   +183 more
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APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia

Nature
Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1.
Michael Haney, Róbert Pálovics, C. Munson, Chris M. Long, Patrik K. Johansson, Oscar Yip, Wentao Dong, Eshaan S. Rawat, Elizabeth West, J. Schlachetzki, A. Tsai, Ian H. Guldner, Bhawika S. Lamichhane, Amanda Smith, N. Schaum, Kruti Calcuttawala, Andrew Shin, Yung-Hua Wang, Chengzhong Wang, Nicole Koutsodendris, G. Serrano, T. Beach, Eric M. Reiman, Christopher K. Glass, Monther Abu-Remaileh, Annika Enejder, Yadong Huang, Tony Wyss-Coray   +27 more
semanticscholar   +1 more source