Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]
, 2012 BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman +8 more
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Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Frontiers in Cellular Neuroscience, 2020 Inflammatory processes and microglia activation accompany most of the pathophysiological diseases in the central nervous system. It is proven that glial pathology precedes and even drives the development of multiple neurodegenerative conditions.
A. Jurga, Martyna Paleczna, K. Kuter
semanticscholar +1 more source
Rod microglia: a morphological definition. [PDF]
PLoS ONE, 2014 Brain microglial morphology relates to function, with ramified microglia surveying the micro-environment and amoeboid microglia engulfing debris. One subgroup of microglia, rod microglia, have been observed in a number of pathological conditions, however
Samuel E Taylor +3 more
doaj +1 more source
Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue
Biomolecules, 2022 Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system.
Christopher E. G. Uff +3 more
doaj +1 more source
Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
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APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
NatureSeveral genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1.
Michael Haney +27 more
semanticscholar +1 more source
Microglia in Parkinson’s Disease
Journal of Parkinson's Disease, 2022 Microglia are the primary resident immune cells of the central nervous system. Neuropathological reports have identified augmented microglial activation in brains of patients with neurodegenerative disorders including Parkinson’s disease (PD).
N. Stefanova
semanticscholar +1 more source
New insight on microglia activation in neurodegenerative diseases and therapeutics
Frontiers in Neuroscience, 2023 Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu +6 more
doaj +1 more source
Transcriptional and translational differences of microglia from male and female brains [PDF]
, 2019 Sex differences in brain structure and function are of substantial scientific interest because of sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a common denominator of many of these diseases and thus microglia
Güneykaya, Dilansu
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Tools and Approaches for Studying Microglia In vivo
Frontiers in Immunology, 2020 Microglia are specialized resident macrophages of the central nervous system (CNS) that have important functions during neurodevelopment, homeostasis and disease.
Elisa Eme-Scolan +2 more
doaj +1 more source