Projected $t$-SNE for batch correction [PDF]
Bioinformatics, 2020, 1-6, 2019 Biomedical research often produces high-dimensional data confounded by batch effects such as systematic experimental variations, different protocols and subject identifiers. Without proper correction, low-dimensional representation of high-dimensional data might encode and reproduce the same systematic variations observed in the original data, and ...
arxiv +1 more source
Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration
Frontiers in Neuroanatomy, 2017 Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou +8 more
doaj +1 more source
Thematic analysis of multiple sclerosis research by enhanced strategic diagram [PDF]
arXiv, 2021 This bibliometric review summarised the research trends and analysed research areas in multiple sclerosis (MS) over the last decade. The documents containing the term "multiple sclerosis" in the article title were retrieved from the Scopus database. We found a total of 18003 articles published in journals in the English language between 2012 and 2021 ...
arxiv
Autism spectrum disorder: a neuro-immunometabolic hypothesis of the developmental origins [PDF]
Biology 2023, 2019 Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes and microglia, among the brain's non-neuronal glia cell populations, play a pivotal role in neurodevelopment, predisposition to and initiation of disease throughout lifespan.
arxiv +1 more source
EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]
, 2019 Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe +6 more
core +1 more source
A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation. [PDF]
, 2020 BackgroundInteractions between neurons, astrocytes, and microglia critically influence neuroinflammatory responses to insult in the central nervous system.
Goshi, Noah +3 more
core
Microglial subtypes: diversity within the microglial community [PDF]
, 2019 Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill multiple functions across development and adulthood and under disease conditions. Current understanding revolves around microglia
Joseph, Bertrand +3 more
core +1 more source
Microglia in Development and Disease [PDF]
Clinical and Developmental Immunology, 2013 The first special issue on microglia was published in 1993 in Glia and others followed in regular, roughly ten-year intervals. Clearly, the importance of microglia has been recognized since the 1980s while the journal Glia has (appropriately) taken the lead in regularly reviewing microglial biology. Also there have been others. The current issue is the
Anirban Ghosh +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]
, 2018 The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro +7 more
core +3 more sources