A richer and more diverse future for microglia phenotypes
Heliyon, 2023 Microglia are the only resident innate immune cells derived from the mesoderm in the nerve tissue. They play a role in the development and maturation of the central nervous system (CNS).
Jie Wang, Wenbin He, Junlong Zhang
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Effects of lipopolysaccharide-induced inflammation on expression of growth-associated genes by corticospinal neurons [PDF]
, 2006 Background: Inflammation around cell bodies of primary sensory neurons and retinal ganglion cells enhances expression of neuronal growth-associated genes and stimulates axonal regeneration.
Anderson, PN +5 more
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease
Acta Neuropathologica, 2021 Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads.
E. Gerrits +13 more
semanticscholar +1 more source
An updated assessment of microglia depletion: current concepts and future directions
Molecular Brain, 2017 Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly
Jinming Han +2 more
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New insight on microglia activation in neurodegenerative diseases and therapeutics
Frontiers in Neuroscience, 2023 Microglia are immune cells within the central nervous system (CNS) closely linked to brain health and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Yucong Xu +6 more
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Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencing. [PDF]
, 2019 Neuroinflammation commonly accompanies neurodegeneration, but the specific roles of resident and infiltrating immune cells during degeneration remains controversial.
Burns, Marie E +3 more
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Microglia in Parkinson’s Disease
Journal of Parkinson's Disease, 2022 Microglia are the primary resident immune cells of the central nervous system. Neuropathological reports have identified augmented microglial activation in brains of patients with neurodegenerative disorders including Parkinson’s disease (PD).
N. Stefanova
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EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]
, 2019 Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe +6 more
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TREM2-dependent effects on microglia in Alzheimer\u27s Disease [PDF]
, 2018 Alzheimer’s disease (AD) is a late-onset dementia characterized by the deposition of amyloid plaques and formation of neurofibrillary tangles (NFTs) which lead to neuronal loss and cognitive deficits.
Colonna, Marco +2 more
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Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Frontiers in Cellular Neuroscience, 2020 Inflammatory processes and microglia activation accompany most of the pathophysiological diseases in the central nervous system. It is proven that glial pathology precedes and even drives the development of multiple neurodegenerative conditions.
A. Jurga, Martyna Paleczna, K. Kuter
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