Results 51 to 60 of about 242,823 (354)
Microbiology Spectrum, 2016 ABSTRACT The concept of the immunological privilege of the central nervous system (CNS) has had a profound influence on studies of interactions between the immune system and the CNS. At one time there was considerable debate as to whether there were any cells in the CNS of myeloid origin, but we now know that there are a number of populations
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IBRO Neuroscience Reports, 2021 Morphological and functional characterizations of cultured microglia are essential for the improved understanding of their roles in neuronal health and disease.
Karolina Dulka +3 more
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Translational Psychiatry, 2022 Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known regarding ...
Pamela M. Maras +6 more
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Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration
Frontiers in Neuroanatomy, 2017 Microglia activation is recognized as the hallmark of neuroinflammation. However, the activation profile and phenotype changes of microglia during the process of retinal degeneration are poorly understood.
Tian Zhou +8 more
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Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
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Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
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FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
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Scientific Reports, 2023 Retinal pathological neovascularization involves endothelial cells, pericytes, photoreceptor cells, ganglion cells, and glial cells, whose roles remain unclear.
Lushu Chen +5 more
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Antioxidants, 2020 Neurodegenerative disorders, such as Alzheimer’s disease, are a global public health burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are undoubtedly hallmarks of neurodegeneration, contributing to disease progression.
Dominic S A Simpson, P. Oliver
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Microglia in Development and Disease [PDF]
Clinical and Developmental Immunology, 2013 The first special issue on microglia was published in 1993 in Glia and others followed in regular, roughly ten-year intervals. Clearly, the importance of microglia has been recognized since the 1980s while the journal Glia has (appropriately) taken the lead in regularly reviewing microglial biology. Also there have been others. The current issue is the
Anirban Ghosh +3 more
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