Results 81 to 90 of about 129,518 (327)

Aged lipid‐laden microglia display impaired responses to stroke

EMBO Molecular Medicine, 2022
Microglial cells of the aged brain manifest signs of dysfunction that could contribute to the worse neurological outcome of stroke in the elderly. Treatment with colony‐stimulating factor 1 receptor antagonists enables transient microglia depletion that ...
Maria Arbaizar‐Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Planas   +6 more
doaj   +1 more source

Transscleral Optical Phase Imaging of the Human Retina - TOPI [PDF]

, 2019
The in vivo observation of the human retina at the cellular level is crucial to detect lesions before irreversible visual loss occurs, to follow the time course of retinal diseases and to evaluate and monitor the early effects of treatments. Despite the phenomenal advances in optical coherence tomography (OCT) and adaptive optics systems, in vivo ...
arxiv   +1 more source

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. [PDF]

, 2019
Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival.
Bollag, Gideon, Broome, Stephanie, Burton, Elizabeth A, Crapser, Joshua, Green, Kim N, Habets, Gaston, Hohsfield, Lindsay A, Ibrahim, Prabha, Lin, Jack, Nespi, Marika, Phan, Nicole Y, Rymar, Andrey, Severson, Paul L, Singh, Parmveer, Spangenberg, Elizabeth, Spevak, Wayne, Tsang, Garson, Walters, Jason, West, Brian L, Zhang, Chao, Zhang, Jiazhong, Zhang, Ying   +21 more
core  

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

Cell Reports, 2019
Summary: Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity. However, the signaling pathways and environmental cues that drive diverse states of microglia are incompletely ...
Sarah R. Anderson, Jacqueline M. Roberts, Jianmin Zhang, Michael R. Steele, Cesar O. Romero, Alejandra Bosco, Monica L. Vetter   +6 more
doaj  

What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior

Frontiers in Cellular Neuroscience, 2022
Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing ...
Bernadette Basilico, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Silvia Di Angelantonio, Davide Ragozzino, Davide Ragozzino, Ingrid Reverte, Ingrid Reverte   +8 more
doaj   +1 more source

Regional microglia are transcriptionally distinct but similarly exacerbate neurodegeneration in a culture model of Parkinson\u27s disease. [PDF]

, 2018
BACKGROUND: Parkinson\u27s disease (PD) is characterized by selective degeneration of dopaminergic (DA) neurons of the substantia nigra pars compacta (SN) while neighboring ventral tegmental area (VTA) DA neurons are relatively spared.
Cai, Jingli, Iacovitti, Lorraine, Kostuk, Eric Wildon   +2 more
core   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Microglia in Neuronal Circuits [PDF]

Neural Plasticity, 2013
Microglia comprise a unique subset of glial cells as the principal brain immune cells and are actively engaged in physiological and pathological brain functions. Unlike other resident neural cells that are of neuroectodermal origin, microglia are of mesodermal origin and invade the neuroepithelium at early embryonic stages.
Long-Jun Wu, Beth Stevens, Shumin Duan, Brian A. MacVicar   +3 more
openaire   +4 more sources