Results 11 to 20 of about 42,496 (156)

Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining. [PDF]

PLoS Pathogens, 2021
MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes.
Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Maggie Cam, Stephen H Hughes, Paul F Lambert, Zhi-Ming Zheng   +10 more
doaj   +3 more sources

Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism. [PDF]

PLoS Genet, 2016
The parasite Leishmania often relies on gene rearrangements to survive stressful environments. However, safeguarding a minimum level of genome integrity is important for cell survival. We hypothesized that maintenance of genomic integrity in Leishmania would imply a leading role of the MRE11 and RAD50 proteins considering their role in DNA repair ...
Laffitte MC, Leprohon P, Hainse M, Légaré D, Masson JY, Ouellette M.   +5 more
europepmc   +7 more sources

Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma [PDF]

The Journal of Clinical Investigation
Oncogene expression can cause replication stress (RS), leading to DNA double-strand breaks (DSBs) that require repair through pathways such as homologous recombination, nonhomologous end-joining, and microhomology-mediated end-joining (MMEJ).
Jithma P. Abeykoon, Shuhei Asada, Guangli Zhu, Yuna Hirohashi, Lisa Moreau, Divya Iyer, Sirisha Mukkavalli, Kalindi Parmar, Gabriella Zambrano, Lige Jiang, Dongni Yi, Michelle Manske, Kimberly Gwin, Rebecca L. King, James R. Cerhan, Xiaosheng Wu, Zhenkun Lou, Geoffrey I. Shapiro, Thomas Witzig, Alan D’Andrea   +19 more
doaj   +3 more sources

Human papillomavirus 16 promotes microhomology-mediated end-joining. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance Cancers associated with the human papillomavirus, including oropharyngeal, anal canal, cervical, and vulvar carcinomas, constitute about 4.5% of all solid tumors. In many cases, they can be readily cured with radiotherapy, which is the mainstay of treatment. HPV-associated cancers are more radiosensitive than HPV-negative cancers,
Leeman JE, Li Y, Bell A, Hussain SS, Majumdar R, Rong-Mullins X, Blecua P, Damerla R, Narang H, Ravindran PT, Lee NY, Riaz N, Powell SN, Higginson DS.   +13 more
europepmc   +5 more sources

Microhomology Selection for Microhomology Mediated End Joining in Saccharomyces cerevisiae. [PDF]

Genes (Basel), 2019
Microhomology-mediated end joining (MMEJ) anneals short, imperfect microhomologies flanking DNA breaks, producing repair products with deletions in a Ku- and RAD52-independent fashion. Puzzlingly, MMEJ preferentially selects certain microhomologies over others, even when multiple microhomologies are available.
Lee K, Ji JH, Yoon K, Che J, Seol JH, Lee SE, Shim EY.   +6 more
europepmc   +6 more sources

Microhomology-mediated end joining: Good, bad and ugly. [PDF]

Mutat Res, 2018
DNA double-strand breaks (DSBs) are induced by a variety of genotoxic agents, including ionizing radiation and chemotherapy drugs for treating cancers. The elimination of DSBs proceeds via distinctive error-free and error-prone pathways. Repair by homologous recombination (HR) is largely error-free and mediated by RAD51/BRCA2 gene products.
Seol JH, Shim EY, Lee SE.
europepmc   +5 more sources

Risky business: Microhomology-mediated end joining. [PDF]

Mutat Res, 2016
Prevalence of microhomology (MH) at the breakpoint junctions in somatic and germ-line chromosomal rearrangements and in the programmed immune receptor rearrangements from cells deficient in classical end joining reveals an enigmatic process called MH-mediated end joining (MMEJ).
Sinha S, Villarreal D, Shim EY, Lee SE.
europepmc   +5 more sources

Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ. [PDF]

Nat Struct Mol Biol, 2015
Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand break-repair pathway that uses sequence microhomology to recombine broken DNA. Although MMEJ has been implicated in cancer development, the mechanism of this pathway is unknown. We demonstrate that purified human DNA polymerase θ (Polθ) performs MMEJ of DNA containing
Kent T, Chandramouly G, McDevitt SM, Ozdemir AY, Pomerantz RT.   +4 more
europepmc   +5 more sources

A role for human homologous recombination factors in suppressing microhomology-mediated end joining. [PDF]

Nucleic Acids Res, 2016
DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways.
Ahrabi S, Sarkar S, Pfister SX, Pirovano G, Higgins GS, Porter AC, Humphrey TC.   +6 more
europepmc   +8 more sources

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? [PDF]

Trends Biochem Sci, 2015
DNA double-strand breaks (DSBs) disrupt the continuity of chromosomes and their repair by error-free mechanisms is essential to preserve genome integrity. Microhomology-mediated end joining (MMEJ) is an error-prone repair mechanism that involves alignment of microhomologous sequences internal to the broken ends before joining, and is associated with ...
Sfeir A, Symington LS.
europepmc   +5 more sources