Results 21 to 30 of about 42,496 (156)

Microhomology-mediated end joining drives complex rearrangements and overexpression of MYC and PVT1 in multiple myeloma. [PDF]

Haematologica, 2020
Abstract MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We show that
Mikulasova A, Ashby C, Tytarenko RG, Qu P, Rosenthal A, Dent JA, Ryan KR, Bauer MA, Wardell CP, Hoering A, Mavrommatis K, Trotter M, Deshpande S, Yaccoby S, Tian E, Keats J, Auclair D, Jackson GH, Davies FE, Thakurta A, Morgan GJ, Walker BA.   +21 more
europepmc   +7 more sources

Osteogenesis Imperfecta with a gross deletion including the COL1A1 gene, induced by Alu-driven microhomology-mediated end joining [PDF]

Bone Reports
Osteogenesis Imperfecta (OI) is a rare hereditary brittle bone disorder typically caused by COL1A1 and COL1A2 variants impairing type I collagen. However, gross deletions involving COL1A1 are uncommon.
Kenichi Yamamoto, Hirofumi Nakayama, Yusaku Ito, Masaya Hattori, Takaaki Shimada, Ikumi Ueda, Takeshi Ishimi, Chieko Yamada, Yukako Nakano, Makoto Fujiwara, Takuo Kubota, Yasuhisa Ohata, Yasuji Kitabatake   +12 more
doaj   +2 more sources

A High-Efficiency CRISPR–Cas9 Ribonucleoprotein Genome Editing System in Aspergillus fijiensis Enabled by Microhomology-Mediated End Joining [PDF]

Journal of Fungi
Aspergillus fijiensis is an industrially important filamentous fungus, whose genetic analysis has been limited by the absence of species-specific tools. This study establishes an optimized CRISPR–Cas9 genome editing platform for A.
Zhenchun Duan, Shuangfei Zhang, Xueduan Liu   +2 more
doaj   +2 more sources

Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ [PDF]

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Samuel J. Black, Ahmet Y. Ozdemir, Ekaterina Kashkina, Tatiana Kent, Timur Rusanov, Dejan Ristic, Yeonoh Shin, Antonio Suma, Trung Hoang, Gurushankar Chandramouly, Labiba A. Siddique, Nikita Borisonnik, Katherine Sullivan-Reed, Joseph S. Mallon, Tomasz Skorski, Vincenzo Carnevale, Katsuhiko S. Murakami, Claire Wyman, Richard T. Pomerantz   +18 more
doaj   +2 more sources

Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair. [PDF]

PLoS Genet, 2017
Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins.
Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, McVey M.   +7 more
europepmc   +4 more sources

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining [PDF]

Cell Cycle, 2010
The human disorder ataxia telangiectasia (AT), which is characterized by genetic instability and neurodegeneration, results from mutation of the ataxia telangiectasia mutated (ATM) kinase. The loss of ATM leads to cell cycle checkpoint deficiencies and other DNA damage signaling defects that do not fully explain all pathologies associated with A-T ...
Elias A, Rahal, Leigh A, Henricksen, Yuling, Li, R Scott, Williams, John A, Tainer, Kathleen, Dixon   +5 more
openaire   +3 more sources

Polλ promotes microhomology-mediated end-joining. [PDF]

Nat Struct Mol Biol, 2023
The double-strand break (DSB) repair pathway called microhomology-mediated end-joining (MMEJ) is thought to be dependent on DNA polymerase theta (Polθ) and occur independently of nonhomologous end-joining (NHEJ) factors. An unresolved question is whether MMEJ is facilitated by a single Polθ-mediated end-joining pathway or consists of additional ...
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert ML, Tredinnick T, Ozdemir AY, Kent T, Demidova EV, Arora S, Wilson SH, Pomerantz RT.   +11 more
europepmc   +3 more sources

Beyond Short Microhomologies: Mismatch-Compatible Pol θ-Mediated DNA Damage Repair. [PDF]

Bioessays
Pol θ is traditionally thought to use a short, perfectly matched microhomology (MH) to initiate end‐joining repair of a DNA double‐strand break. Emerging evidence indicates that Pol θ generally utilizes mismatch‐compatible longer microhomologies. This revised definition of MH is applicable across species and broadens the definition of Pol θ‐associated ...
Li Y, Wood RD.
europepmc   +2 more sources

Microhomology-mediated end-joining Knock-In approaches to delete the allergenic domain of trout parvalbumin beta-1. Preliminary results in F0 animals and feedback [version 2; peer review: 1 approved, 2 approved with reservations] [PDF]

Open Research Europe
Background Gene editing techniques offer new opportunities to improve important traits in aquaculture. The allergenicity of fish flesh is a major problem in aquaculture. Parvalbumin (Parv) is the most prevalent fish allergen.
Amaury Herpin, Cecile Duret, Pierre-yves Rescan, Veronique Lebret   +3 more
doaj   +2 more sources

Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy. [PDF]

Cancer Res, 2020
Abstract Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-dependent repair and classical nonhomologous end-joining. Recent studies have identified a third pathway, microhomology-mediated end-joining (MMEJ).
Patterson-Fortin J, D'Andrea AD.
europepmc   +4 more sources