Nano-Micro Letters, 2021 Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine interface.
Hyeonhee Roh +6 more
doaj +1 more source
Extensive collection of femtoliter pad secretion droplets in beetle Leptinotarsa decemlineata allows nanoliter microrheology [PDF]
, 2010 Pads of beetles are covered with long, deformable setae, each ending in a micrometric terminal plate coated with secretory fluid. It was recently shown that the layer of the pad secretion covering the terminal plates is responsible for the generation of ...
Bastien Laurent +14 more
core +3 more sources
Microneedle physical contact as a therapeutic for abnormal scars
European Journal of Medical Research, 2017 Background Abnormal (keloid and hypertrophic) scars are a significant affliction with no satisfactory single modality therapy to-date. Available options are often ineffective, painful, potentially hazardous, and require healthcare personnel involvement ...
David C. Yeo +3 more
doaj +1 more source
Multifunctional polysaccharide composited microneedle for oral ulcers healing
Materials Today Bio, 2023 Oral ulcers have periodicity and recurrence, and the etiology and causative mechanisms remain unclear; therefore, it is difficult to treat oral ulcers effectively.
Yiyu Zeng +6 more
doaj +1 more source
A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines following intradermal and intramuscular administration [PDF]
, 2014 Strategies to optimize responses to seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery.
Castellino, Flora +9 more
core +1 more source
Substrate Deformation Predicts Neuronal Growth Cone Advance [PDF]
, 1977 Although pulling forces have been observed in axonal growth for several decades, their underlying mechanisms, absolute magnitudes, and exact roles are not well understood.
Athamneh, Ahmad I.M. +3 more
core +1 more source
Microneedle-Based Vaccines [PDF]
, 2009 The threat of pandemic influenza and other public health needs motivate the development of better vaccine delivery systems. To address this need, microneedles have been developed as micron-scale needles fabricated using low-cost manufacturing methods that administer vaccine into the skin using a simple device that may be suitable for self ...
Mark R, Prausnitz +3 more
openaire +2 more sources
Separable arrowhead microneedles [PDF]
Journal of Controlled Release, 2011 Hypodermic needles cause pain and bleeding, produce biohazardous sharp waste and require trained personnel. To address these issues, we introduce separable arrowhead microneedles that rapidly and painlessly deliver drugs and vaccines to the skin. These needles are featured by micron-size sharp tips mounted on blunt shafts.
Leonard Y, Chu, Mark R, Prausnitz
openaire +2 more sources
MICRONEEDLE STRUCTURE DESIGN AND OPTIMIZATION USING GENETIC ALGORITHM [PDF]
Journal of Engineering Science and Technology, 2015 This paper presents a Genetic Algorithm (GA) based microneedle design and analysis. GA is an evolutionary optimization technique that mimics the natural biological evolution.
N. A. ISMAIL +3 more
doaj
MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing
Research, 2021 Wound healing is a complex physiological process that involves coordinated phases such as inflammation and neovascularization. Attempts to promote the healing process tend to construct an effective delivery system based on different drugs and materials ...
Lingyu Sun +5 more
doaj +1 more source