Results 71 to 80 of about 36,831 (386)
Pharmaceutics, 2022 Microneedles have emerged as a novel transdermal delivery tool that enables the delivery of various products such as drugs, vaccines, or cosmetic ingredients. Although the demand for solid microneedles composed of biocompatible polymer is increasing, the
Seongsu Kang +4 more
doaj +1 more source
Microorganism microneedle micro-engine depth drug delivery
Nature CommunicationsAs a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current microneedles rely on passive diffusion, leading to uncontrollable drug penetration.
Bin Zheng +11 more
semanticscholar +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery
Science Advances, 2022 We developed a dynamic omnidirectional adhesive microneedle system that improves the oral delivery of macromolecules.
Wei Chen +14 more
semanticscholar +1 more source
Smart Microneedles for Therapy and Diagnosis [PDF]
Research, 2020 Microneedles represent a cutting-edge and idea-inspiring technology in biomedical engineering, which have attracted increasing attention of scientific researchers and medical staffs. Over the past decades, numerous great achievements have been made. The fabrication process of microneedles has been simplified and becomes more precise, easy-to-operate ...
Xiaoxuan Zhang +5 more
openaire +4 more sources
Transdermal Delivery of Functional Collagen \u3cem\u3eVia\u3c/em\u3e Polyvinylpyrrolidone Microneedles [PDF]
, 2015 Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities.
Inayathullah, Mohammed +9 more
core +1 more source
Advanced Functional Materials, EarlyView.The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar +6 more
wiley +1 more source
Materials & Design, 2021 In this study, we prepared a novel microneedle patch using metal bioelectrodes that provide excellent mechanical properties, drug-delivery efficiency, and biocompatibility at the same time.
Su-Jin Yang +3 more
doaj
Transdermal Polymeric Microneedle Sensing Platform for Fentanyl Detection in Biofluid
Biosensors, 2022 Opioid drugs are extremely potent synthetic analytes, and their abuse is common around the world. Hence, a rapid and point-of-need device is necessary to assess the presence of this compound in body fluid so that a timely countermeasure can be provided ...
Pratik Joshi +4 more
doaj +1 more source
Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination [PDF]
, 2012 Transcutaneous administration has the potential to improve therapeutics delivery, providing an approach that is safer and more convenient than traditional alternatives, while offering the opportunity for improved therapeutic efficacy through sustained ...
Ai-Ling, Michelle Lim +4 more
core +1 more source