Results 111 to 120 of about 24,177 (264)
Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma
Brain Pathology, EarlyView.Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza +8 more
wiley +1 more source
Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer
Cancer Science, EarlyView.Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo +6 more
wiley +1 more source
Influence of the radiation on cytogenetic parameters mouselike rodents from the Chornobyl Nuclear Power Plant exclusion zone [PDF]
Ядерна фізика та енергетика, 2013 Results of radioecological and cytogenetic studies are presented. The soil contamination on the testing exper-imental sites of Chornobyl exclusion zone was studied.
O. O. Burdo +4 more
doaj
A Unified Deep Learning Framework for Instance Segmentation Across Diverse Cytological Stains
Cytopathology, EarlyView.Transformer‐based unified cytology segmentation across Papanicolaou, Feulgen and AgNOR achieves stain‐invariant performance. Mask2Former maximises boundary precision (AP75) on the combined dataset, enabling one model to replace multiple stain‐specific deployments without accuracy loss while simplifying clinical integration.
Luís Otávio Santos +6 more
wiley +1 more source
Micronuclei formation in irradiated cell cultures
, 2018 Jeden z cílů této práce je detailně popsat mechanismy poškození jaderné DNA z hlediska radiační fyziky a chemie, spolu s mechanismem vzniku mikrojader v lidských buňkách.
Kaczor Stanislav
core
Increased Genetic Instability in Exfoliated Oral Cells in Patients With Epidermolysis Bullosa
Oral Diseases, EarlyView.ABSTRACT Objective To analyze the nuclear abnormalities of cytotoxicity—karyorrhexis (KR), karyolysis (KL), and pyknosis (PN)—and genotoxicity—micronucleus (MN) in exfoliated cells from different sites of the oral mucosa in patients with Epidermolysis Bullosa (EB) and a control group.
Ana Carolina Sias Franco Franzosi +5 more
wiley +1 more source
Sequence and structural alignments reveal insights into ANKLE2 evolution and function. [PDF]
Protein SciAbstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Fishburn AT +8 more
europepmc +2 more sources
Photochemistry and Photobiology, EarlyView.Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza +4 more
wiley +1 more source
Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source