Results 101 to 110 of about 29,331 (220)

Effect of fluoride toothpaste and mouthwash on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires during comprehensive orthodontic treatment: A randomized clinical trial

Journal of Oral Biology and Craniofacial Research
Objective: To evaluate the effect of fluoride on the cytotoxicity of buccal mucosa cells in the presence of nickel-titanium archwires. Materials and methods: Seventy-five subjects requiring comprehensive orthodontic treatment were randomly allocated to ...
Mayur Bhola, Ashok Kumar Jena, Madhusmita Sethy, Jitendra Sharan   +3 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Mutagenicity and genotoxicity of ClearTaste

Toxicology Reports, 2018
The present study investigates whether ClearTaste is mutagenic/genotoxic by employing it as a test article in bacterial reverse mutation (Ames test) and in vitro human peripheral blood lymphocyte micronucleus assays conducted by a Good Laboratory ...
B.K. Soni, J.P. Langan
doaj   +1 more source

PEGylated Chrysin: In Vitro Biological Activity and Mechanistic Insights in HepG2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
PEGylated chrysin exhibited antiproliferative effects in HepG2 cells, inducing apoptosis, membrane damage, genotoxicity, and wound closure. Compared to paclitaxel, it caused lower ROS production and overall cytotoxicity, while efficiently accumulating in the cytoplasm, supporting its potential as a liver cancer therapeutic candidate. ABSTRACT PEGylated
Fátima Belén Gasser, Julia Oggero, María Sol Renna, María Florencia Beltramino, Candela Simonetto, Lucía Dominguez, Hugo Héctor Ortega, Santiago Eduardo Vaillard, Victoria Anahí Vaillard, María Eugenia Baravalle   +9 more
wiley   +1 more source

Protein Lactylation in Cancer: From Mechanisms to Therapy

MedComm, Volume 7, Issue 11, November 2026.
Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang, Ping Hu, Shun Wang, Xide Zhang, Ziran Ye, Shengqiang Chen, Fu Gao, Yuanyuan Chen, Yanyong Yang   +8 more
wiley   +1 more source

Pharmacological and Therapeutic Potential of Garlic (Allium sativum): Integrating Phytochemistry, Molecular Mechanisms, and Clinical and Preclinical Evidence

ChemistryOpen, Volume 15, Issue 11, November 2026.
Garlic bioactive compounds, including organosulfur compounds (allicin, DADS, DATS, and SAC), phenolic compounds, and quercetin, regulate the Nrf2/HO‐1, NF‐κB, PI3K/Akt, and AMPK/eNOS signaling pathways. These actions enhance antioxidant defenses, suppress inflammation, improve metabolic and cardiovascular function, and contribute to reduced blood ...
Gudisa Bereda
wiley   +1 more source

Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps

, 2008
AIM: To determine, by counting micronucleus (MN) frequencies, whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC)
Kabalar, Mehmet Esref, Binici, Dogan Nasir, Karaman, Ali, Calikusu, Zueleyha   +3 more
core   +1 more source

Mitigating Photoinduced Reactive Oxygen Species From TiO2 and ZnO UV Filters: Materials Design and Evaluation

ChemistrySelect, Volume 11, Issue 42, 10 November 2026.
Photoinduced reactive oxygen species (ROS) from titanium dioxide (TiO2) and zinc oxide (ZnO) ultraviolet (UV) filters can be controlled through particle engineering, surface passivation, and formulation design. This Review links material structure and interfacial chemistry with ROS evaluation and proposes a tiered framework from photoreactivity ...
Chenge Wang
wiley   +1 more source

Protective effect of methanolic extracts of thymus vulgaris against cyclophosphamide- induced DNA damage in mouse bone marrow cells using the micronucleus test [PDF]

Trends in Pharmaceutical Sciences, 2015
Introduction: Cyclophosphamide is a chemo-therapeutic agent in the treatment of the various cancers and autoimmune diseases. This composition has cytotoxic and clastogenic properties.
Abbas Salmani, Ali Kosari, Aliyar Pirouzi, Marjan Omidi, Mehdi Mohsenzadeh   +4 more
doaj  

Micronuclei and Other Nuclear Abnormalities in Patella Limpet as Biomarkers of Cytogenotoxicity in Recreational Port Waters

Environmental Toxicology, Volume 41, Issue 11, Page 1125-1138, November 2026.
ABSTRACT Over the past decades, the growth in human population and economic activities has led to an increase in maritime traffic. This rise puts additional pressure on marine environments, vessel fuel spills being considered to have a major impact on the ecosystem.
Carlos Valiente‐Diaz, Eva Garcia‐Vazquez, Verónica Soto‐López   +2 more
wiley   +1 more source