Results 81 to 90 of about 29,331 (220)
, 2017 Exposure of genotoxic substances come from various sources such as food additives. The aim of this study is to evaluate the genotoxicity of food additives in CHO-K1 cells by micronucleus test flow cytometry.
Herwandhani Putri +5 more
core +1 more source
Chromosomal and immune dysregulation underlying granular mitosis in glioblastoma
Brain Pathology, EarlyView.Granular mitosis (GM) morphology is linked to PI3K/PTEN pathway alterations, chromosomal disorganization, and impaired innate immunity. Cells exhibiting GM morphology are associated with localized immune responses within their immediate spatial microenvironment.
Rachel Barboza +8 more
wiley +1 more source
, 2009 This report describes the aims, discussion and outcomes of the first Human Micronucleus collaborative project workshop on the buccal micronucleus assay. It was agreed at the workshop that three activities should be initiated as soon as possible namely (i)
Holland, Nina +4 more
core +1 more source
Cancer Science, EarlyView.UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka +2 more
wiley +1 more source
Genetics and Molecular Biology, 2007 The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice.
Ximena C. Abrevaya +2 more
doaj +1 more source
Micronucleus-Specific DNA Sequences in an Amicronucleate Mutant of Tetrahymena
, 1984 DNA from the amicronucleate Tetrahymena cell line BI3840 was probed for DNA sequences which are limited to the micronucleus in wild-type cells. Four micronucleus-specific DNA sequences were not detectable in DNA from the amicronucleate cell line.
Karrer, Kathleen M. +2 more
core +1 more source
Clinical Oral Implants Research, EarlyView.ABSTRACT Background Postmenopausal osteoporosis associated with cafeteria diet and bisphosphonate therapy may impair peri‐implant bone repair. Therefore, strategies to enhance osseointegration are needed. Aim This study investigated whether teriparatide‐coated implant surfaces enhance osseointegration in a rodent model of estrogen deficiency (OVX) and ...
Ana Cláudia Ervolino da Silva +9 more
wiley +1 more source
Plant Breeding, EarlyView.ABSTRACT The combination of polyploidy, apomixis and the formation of aneuploid and interploid hybrids makes the genus Urochloa an interesting system for investigating meiotic stability and genome behaviour in grasses. In this study, routine meiotic analysis and genomic in situ hybridization (GISH) were used to (i) evaluate meiosis in three hybrids of ...
Isabella Campos Moraes +3 more
wiley +1 more source
Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, Volume 20, Issue 11, Page 2820-2838, November 2026.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source