Results 181 to 190 of about 29,331 (220)

Tradescantia micronucleus bioassay

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1994
Four coded chemicals, azidoglycerol (AG), N-methyl-N-nitrosourea (MNU), sodium azide (NaN3), and maleic hydrazide (MH), were tested with the Tradescantia micronucleus (Trad-MCN) bioassay by five independent laboratories from five different countries. The purpose of this international collaborative study was to evaluate four plant bioassays, of which ...
T H, Ma, G L, Cabrera, R, Chen, B S, Gill, S S, Sandhu, A L, Vandenberg, M F, Salamone   +6 more
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Micronucleus and its applications

Diagnostic Cytopathology, 2010
AbstractMicronucleus (MN) is a small additional nucleus and is readily identifiable by light microscopy. Biologically, micronuclei are the chromosome fragments or whole chromosomes that lag behind at anaphase during nuclear division. MN occurs due to genetic damage of the cell and the MN scoring is the indicator of the genetic damage.
Swapan, Samanta, Pranab, Dey
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The in vitro micronucleus technique

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
The study of DNA damage at the chromosome level is an essential part of genetic toxicology because chromosomal mutation is an important event in carcinogenesis. The micronucleus assays have emerged as one of the preferred methods for assessing chromosome damage because they enable both chromosome loss and chromosome breakage to be measured reliably ...
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Buccal micronucleus cytome assay

Nature Protocols, 2009
The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for studying DNA damage, chromosomal instability, cell death and the regenerative potential of human buccal mucosal tissue. This method is increasingly used in molecular epidemiological studies for investigating the impact of nutrition, lifestyle factors, genotoxin exposure and
Thomas, P., Holland, N., Bolognesi, C., Kirsch-Volders, M., Bonassi, S., Zeiger, E., Knasmueller, S., Fenech, M.   +7 more
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Mussel micronucleus cytome assay

Nature Protocols, 2012
The micronucleus (MN) assay is one of the most widely used genotoxicity biomarkers in aquatic organisms, providing an efficient measure of chromosomal DNA damage occurring as a result of either chromosome breakage or chromosome mis-segregation during mitosis.
Claudia, Bolognesi, Michael, Fenech
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A micromethod for the in vitro micronucleus assay

Mutagenesis, 1999
A micromethod for the in vitro micronucleus assay was developed using L5178Y cells to enable the rapid screening of a large number of molecules. The method is quick, simple to perform and needs very small amounts of compound, i.e.
F, Nesslany, D, Marzin
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Micronucleus in atypical urothelial cells

Diagnostic Cytopathology, 2010
AbstractThe objective of this study is to evaluate the role of micronuclei (MN) in identifying the atypical urothelial cells urinary cytology. This is a retrospective study of a total of 30 cases of urine samples. Of these, 15 cases were selected where the initial diagnosis was atypical urothelial cell and later turned out as malignant cells on follow ...
Sandeep Kumar, Arora, Pranab, Dey, Uma Nahar, Saikia   +2 more
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Evaluation of a modified micronucleus assay

International Journal of Radiation Biology, 1996
The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus assay was determined in three established cell lines (L929, HL-60, and Chang). Our data revealed a dose-dependent increase of cells bearing multiple micronuclei.
M, Abend, A, Rhein, K P, Gilbertz, D, Van Beuningen   +3 more
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The In Vitro Micronucleus Assay

2011
The in vitro micronucleus test detects genotoxic damage in interphase cells. The in vitro micronucleus test provides an alterative to the chromosome aberration test, and because the in vitro micronucleus test examines cells at interphase, the assessment of micronuclei can be scored faster, as the analysis of damage is thought to be less subjective and ...
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Sampling times in micronucleus testing

Mutation Research Letters, 1992
A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
P, Vanparys, G, Deknudt, F, Vermeiren, M, Sysmans, R, Marsboom   +4 more
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