Results 191 to 200 of about 29,331 (220)

The effect of benzene in the micronucleus test

Mutation Research/Genetic Toxicology, 1980
The potential cytogenetic effect of benzene was studied by means of the micronucleus test in developing erythrocytes of male and female mice at dosages ranging from 0.0625 to 2.0 ml/kg/day. Groups of mice were given two daily oral doses and sacrificed 6, 18, 24 or 48 h, or 5, 9 or 16 days after the last dose. The doses were given 24 h apart.
M, Hite, M, Pecharo, I, Smith, S, Thornton   +3 more
openaire   +2 more sources

Effect of erythropoietin on the micronucleus test

Environmental and Molecular Mutagenesis, 1989
AbstractThe micronucleus test is used widely as an in vivo short‐term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
Y, Suzuki, Y, Nagae, T, Ishikawa, Y, Watanabe, T, Nagashima, K, Matsukubo, H, Shimizu   +6 more
openaire   +2 more sources

Clinical experience with the micronucleus assay

Journal of Cellular Biochemistry, 1993
Because of the logistical and practical problems that make cancer prevention trials using cancer incidence as an endpoint virtually impossible to conduct for the majority of cancer types, there is a desperate need for valid intermediate markers of cancer risk to serve as surrogate endpoints in chemoprevention trials. A long and continually growing list
H S, Garewal, L, Ramsey, G, Kaugars, J, Boyle   +3 more
openaire   +2 more sources

Statistical analysis of the micronucleus test

Mutation Research, 1984
Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
openaire   +2 more sources

Buccal Micronucleus Cytome Assay

2010
The Buccal Micronucleus Cytome (BMCyt) assay is a new minimally invasive system for studying DNA damage, chromosomal instability, cell death, and the regenerative potential of buccal mucosal tissue. This method is increasingly being used in molecular epidemiologic studies investigating the impact of nutrition, life-style factors, genotoxin exposure ...
Philip, Thomas, Michael, Fenech
openaire   +2 more sources

Micronucleus Analysis by Flow Cytometry

2019
During the last two decades the micronucleus (MN) test has been extensively used as a genotoxicity screening tool of chemicals and in a variety of exploratory and mechanistic investigations. The MN is a biomarker for chromosomal damage or mitotic abnormalities since it can originate from chromosome fragments or whole chromosomes that fail to be ...
Azeddine, Elhajouji, Pascal, Stadelmann
openaire   +2 more sources

The micronucleus test in piscine erythrocytes

Aquatic Toxicology, 2006
Cytogenetic assays on aquatic organisms are essential, as humans are exposed throughout their lifetime to several xenobiotics present in both the water and aquatic food. The micronucleus test showed to be a useful in vivo assay for genotoxicity testing. However, many aspects of its protocol need to be refined, knowledge of confounding factors should be
openaire   +2 more sources

The transplacental micronucleus test

Mutation Research/Environmental Mutagenesis and Related Subjects, 1980
C J, Stoyel, A M, Clark
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Micronucleus

2008
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Micronucleus assay protocols

Mutation Research/Genetic Toxicology, 1991
openaire   +2 more sources