Results 191 to 200 of about 38,648 (228)
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Mussel micronucleus cytome assay
Nature Protocols, 2012The micronucleus (MN) assay is one of the most widely used genotoxicity biomarkers in aquatic organisms, providing an efficient measure of chromosomal DNA damage occurring as a result of either chromosome breakage or chromosome mis-segregation during mitosis.
Claudia, Bolognesi, Michael, Fenech
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Buccal micronucleus cytome assay
Nature Protocols, 2009The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for studying DNA damage, chromosomal instability, cell death and the regenerative potential of human buccal mucosal tissue. This method is increasingly used in molecular epidemiological studies for investigating the impact of nutrition, lifestyle factors, genotoxin exposure and
Thomas, P. +7 more
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Micronucleus and its applications
Diagnostic Cytopathology, 2010AbstractMicronucleus (MN) is a small additional nucleus and is readily identifiable by light microscopy. Biologically, micronuclei are the chromosome fragments or whole chromosomes that lag behind at anaphase during nuclear division. MN occurs due to genetic damage of the cell and the MN scoring is the indicator of the genetic damage.
Swapan, Samanta, Pranab, Dey
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Sampling times in micronucleus testing
Mutation Research Letters, 1992A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
P, Vanparys +4 more
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Buccal Micronucleus Cytome Assay
2010The Buccal Micronucleus Cytome (BMCyt) assay is a new minimally invasive system for studying DNA damage, chromosomal instability, cell death, and the regenerative potential of buccal mucosal tissue. This method is increasingly being used in molecular epidemiologic studies investigating the impact of nutrition, life-style factors, genotoxin exposure ...
Philip, Thomas, Michael, Fenech
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Micronucleus in atypical urothelial cells
Diagnostic Cytopathology, 2010AbstractThe objective of this study is to evaluate the role of micronuclei (MN) in identifying the atypical urothelial cells urinary cytology. This is a retrospective study of a total of 30 cases of urine samples. Of these, 15 cases were selected where the initial diagnosis was atypical urothelial cell and later turned out as malignant cells on follow ...
Sandeep Kumar, Arora +2 more
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The micronucleus test methodological aspects
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973Abstract Changes in the cellular compositiion of bone marrow were studied in relation to dose of Trenimon® and time after treatment. Strong mutagenic effects caused a partial depletion of the marrow cavities of nucleated blood cell precursors, with subsequent retention of newly formed erythrocytes and inundation with peripheral blood.
Von Ledebur, M, Schmid, Werner
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Micronucleus Analysis by Flow Cytometry
2019During the last two decades the micronucleus (MN) test has been extensively used as a genotoxicity screening tool of chemicals and in a variety of exploratory and mechanistic investigations. The MN is a biomarker for chromosomal damage or mitotic abnormalities since it can originate from chromosome fragments or whole chromosomes that fail to be ...
Azeddine, Elhajouji, Pascal, Stadelmann
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The in vitro micronucleus technique
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000The study of DNA damage at the chromosome level is an essential part of genetic toxicology because chromosomal mutation is an important event in carcinogenesis. The micronucleus assays have emerged as one of the preferred methods for assessing chromosome damage because they enable both chromosome loss and chromosome breakage to be measured reliably ...
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Micronucleus Experiments with Reptiles
2019Reptiles remain the least studied group of vertebrates in genetic toxicology, even though they have very interesting characteristics. Our studies conducted on native crocodiles, lizards, and turtles have demonstrated the sensitivity of the micronucleus (MN) test as a good indicator for genotoxicity biomonitoring. Reptiles are relevant components of the
G. L. Poletta, P. A. Siroski
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