Results 51 to 60 of about 59,469 (309)

Genotoxicity of aluminium oxide, iron oxide, and copper nanoparticles in mouse bone marrow cells

Arhiv za Higijenu Rada i Toksikologiju, 2021
The aim of this study was to evaluate the genotoxic effects of Al2O3, Fe2O3, and Cu nanoparticles with chromosomal aberration (CA), micronucleus (MN), and comet assays on the bone marrow of male BALB/c mice.
Sadiq Rakhshinda, Khan Qaiser Mahmood, Mobeen Ameena, Shah Asma   +3 more
doaj   +1 more source

RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay)

International Journal of Radiation Biology, 2017
Purpose: In the framework of the ‘Realizing the European Network of Biodosimetry’ (RENEB) project, two intercomparison exercises were conducted to assess the suitability of an optimized version of the cytokinesis-block micronucleus assay, and to evaluate
Julie Depuydt, A. Baeyens, S. Barnard, C. Beinke, Anett Benedek, P. Beukes, I. Buraczewska, F. Darroudi, S. de Sanctis, I. Domínguez, O. Monteiro Gil, V. Hadjidekova, E. Kis, U. Kulka, F. Lista, K. Lumniczky, R. M’kacher, J. Moquet, D. Obreja, U. Oestreicher, J. Pajic, N. Pastor, Ljubomira Popova, E. Regalbuto, M. Ricoul, L. Sabatier, J. Slabbert, S. Sommer, A. Testa, H. Thierens, A. Wójcik, A. Vral   +31 more
semanticscholar   +1 more source

Herbal Remedies for Combating Irradiation: a Green Antiirradiation Approach [PDF]

, 2014
Plants play important roles in human life not only as suppliers of oxygen but also as a fundamental resource to sustain the human race on this earthly plane.
Choong, Y. S., Deivanai, S., Lachumy, S. J., Latha, L. Y., Oon, C. E., Saravanan, D., Sasidharan, S., Vijayarathna, S., Yeng, C.   +8 more
core   +1 more source

Comparison of established and emerging biodosimetry assays [PDF]

, 2013
Rapid biodosimetry tools are required to assist with triage in the case of a large-scale radiation incident. Here, we aimed to determine the dose-assessment accuracy of the well-established dicentric chromosome assay (DCA) and cytokinesis-block ...
Abend, M, Badie, C, Balagurunathan, Y, Barnard, S, Beinke, C, Bernard, N, Boulay-Greene, H, Braselmann, H, Brengues, M, De Amicis, A, De Sanctis, S, Greither, R, Herodin, F, Jones, A, Kabacik, S, Knie, T, Kulka, U, Lista, F, Martigne, P, Meineke, V, Missel, A, Moquet, J, Oestreicher, U, Peinnequin, A, Poyot, T, Roessler, U, Romm, H, Rothkamm, K, Scherthan, H, Terbrueggen, B, Thierens, Hubert, Valente, M, Vral, Anne, Zenhausern, F   +33 more
core   +2 more sources

Safety evaluation of the food enzyme pullulanase from genetically modified Bacillus subtilis strain NZYM-AK [PDF]

, 2017
Publisher ...
Aguilera-Gómez, Margarita, Bolognesi, Claudia, Castle, Laurence, Chesson, Andrew, Cravedi, Jean-Pierre, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Glandorf, Boet, Grob, Konrad, Gürtler, Rainer, Herman, Lieve, Husøy, Trine, Jany, Klaus-Dieter, Kovalkovičová, Natália, Kärenlampi, Sirpa, Maia, Joaquim, Marcon, Francesca, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Tavares Poças, Maria de Fátima, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia, Želježic, Davor   +29 more
core   +3 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Genotoxicity and histopathological assessment of silver nanoparticles in Swiss albino mice

Cuadernos de investigación UNED, 2018
Silver nanoparticles (AgNPs) are widely used in industrial and medical applications. However, there is a growing concern about the potentialities of AgNPs to induce genotoxicity and DNA damage in humans.
Oluyinka A Iyiola, Temitope F. Olafimihan   +1 more
doaj   +1 more source

Evaluation of the novel liver micronucleus assay using formalin-fixed tissues

Genes and Environment, 2019
The repeated-dose liver micronucleus (RDLMN) assay is an effective and important in vivo test for detecting genotoxic compounds, particularly for those that require metabolic activation to show genotoxicity.
S. Hamada, Miyuki Shigano, Satoru Kawakami, Maya Ueda, H. Sui, Katsuya Yamada, Soichiro Hagio, Ayaka Momonami, A. Maeda, Yukari Terashima, W. Ohyama, T. Morita, M. Hayashi   +12 more
semanticscholar   +1 more source

The micronucleus assay in radiation accidents [PDF]

, 2009
The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents ...
Thierens, Hubert, Vral, Anne
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source