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Buccal micronucleus cytome assay

Nature Protocols, 2009
The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for studying DNA damage, chromosomal instability, cell death and the regenerative potential of human buccal mucosal tissue. This method is increasingly used in molecular epidemiological studies for investigating the impact of nutrition, lifestyle factors, genotoxin exposure and
Thomas, P., Holland, N., Bolognesi, C., Kirsch-Volders, M., Bonassi, S., Zeiger, E., Knasmueller, S., Fenech, M.   +7 more
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Statistical evaluation of the in vivo micronucleus assay

Archives of Toxicology, 2008
The statistical evaluation of the in vivo micronucleus assay is focused on multiple contrast tests for comparisons versus the negative control for count data taking the between-animals variability into account. For a possible claim the compound is not genotoxic in the micronucleus assay a proof of safety approach is proposed.
Ludwig A Hothorn, Daniel Gerhard, Hothorn Ludwig A   +2 more
exaly   +3 more sources

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

Ecotoxicology and Environmental Safety, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
E Pinelli
exaly   +2 more sources

In vivo erythrocyte micronucleus assay

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2007
Makoto Hayashi, Lilianne Abramsson-Zetterberg, Antonella Russo   +2 more
exaly   +2 more sources

Mussel micronucleus cytome assay

Nature Protocols, 2012
The micronucleus (MN) assay is one of the most widely used genotoxicity biomarkers in aquatic organisms, providing an efficient measure of chromosomal DNA damage occurring as a result of either chromosome breakage or chromosome mis-segregation during mitosis.
Claudia, Bolognesi, Michael, Fenech
openaire   +2 more sources

A micromethod for the in vitro micronucleus assay

Mutagenesis, 1999
A micromethod for the in vitro micronucleus assay was developed using L5178Y cells to enable the rapid screening of a large number of molecules. The method is quick, simple to perform and needs very small amounts of compound, i.e.
F, Nesslany, D, Marzin
openaire   +2 more sources

Evaluation of a modified micronucleus assay

International Journal of Radiation Biology, 1996
The relationship between ionizing radiation-induced cell killing and DNA damage measured by the micronucleus assay was determined in three established cell lines (L929, HL-60, and Chang). Our data revealed a dose-dependent increase of cells bearing multiple micronuclei.
M, Abend, A, Rhein, K P, Gilbertz, D, Van Beuningen   +3 more
openaire   +2 more sources

Clinical experience with the micronucleus assay

Journal of Cellular Biochemistry, 1993
Because of the logistical and practical problems that make cancer prevention trials using cancer incidence as an endpoint virtually impossible to conduct for the majority of cancer types, there is a desperate need for valid intermediate markers of cancer risk to serve as surrogate endpoints in chemoprevention trials. A long and continually growing list
H S, Garewal, L, Ramsey, G, Kaugars, J, Boyle   +3 more
openaire   +2 more sources

Micronucleus assay in sea urchin embryos

Mutation Research/Environmental Mutagenesis and Related Subjects, 1996
We have developed a micronucleus assay for use in sea urchin embryos. The embryos at the early blastula stage (about 256 cells) were exposed to genotoxic chemicals overnight until control embryos have reached the gastrula stage. Then all embryos were suspended in 1 M urea, dissociated by pipetting, and fixed with methanol:acetic acid (9:1).
K, Saotome, T, Sofuni, M, Hayashi
openaire   +2 more sources