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Micronucleus Assay with Tetrad Cells of Tradescantia
The Tradescantia micronucleus assay has been used for 50 years for the detection of genotoxins (including carcinogens) in the environment. Micronuclei are extranuclear bodies that contain entire chromosomes or chromosomal fragments and can be scored under the microscope.Miroslav, Mišík +6 more
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The Micronucleus Assay. II. In Vitro
1981The genetic implications of chromosomal translocations, inversions, and deletions for human health are well known (Hamerton, 1971). In addition, the presence of chromosomal aberrations indicates that damage to DNA has occurred. Similarly, sister chromatid exchanges (SCE), whose genetic significance is not known, have been found to be useful as a ...
John A. Heddle +2 more
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Micronucleus assay in freshwater invertebrates
2000The number of micronuclei (MNi) in haemocytes of freshwater mussel Dreissena polymorpha Pall., freshwater snails Planorbarius corneus L. and Lymnaea stagnalis L., and freshwater decapod crustaceans Astacus astacus L. and Austropotamobius torrentium Schr.
Erben, Radovan +3 more
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In Vivo Rodent Micronucleus Assay
2007Genotoxicity plays an important role for the safety evaluation of chemicals. Chromosomal aberration is one of two major end points of genotoxicity. The rodent haematopoietic cell micronucleus assay is most widely used as an in vivo test to evaluate structural and numerical chromosomal aberrations.
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Feasibility of automating the micronucleus assay.
Analytical and quantitative cytology and histology, 1986The results of a feasibility study on the automation of the micronucleus assay in whole blood cultures of human lymphocytes are reported. The assay requires determination of the number of lymphocytes with micronuclei among the proliferating population.
H H, Callisen, M, Pincu, A, Norman
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[Prediction of radiosensitivity by micronucleus assay].
Gan no rinsho. Japan journal of cancer clinics, 1990The correlation between cell survival curve and dose response curve of MN frequency following irradiations was studied using cytokinesis-block method. Both dose response curves were analyzed by linear quadratic model, i.e. SF = exp (- alpha D - beta D2) and MN frequency = aD + bD2 + c.
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In vivo rodent micronucleus assay: protocol, conduct and data interpretation
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000Makoto Hayashi
exaly