Results 171 to 180 of about 15,516,475 (251)
Some of the next articles are maybe not open access.
Statistical analysis of the micronucleus test
Mutation Research, 1984Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
openaire +2 more sources
The micronucleus test methodological aspects
Mutation Research, 1973Changes in the cellular compositiion of bone marrow were studied in relation to dose of Trenimon® and time after treatment. Strong mutagenic effects caused a partial depletion of the marrow cavities of nucleated blood cell precursors, with subsequent retention of newly formed erythrocytes and inundation with peripheral blood.
Von Ledebur, M, Schmid, Werner
openaire +2 more sources
The micronucleus test with mouse spleen cells
Mutation Research Letters, 1983The results of this study show that the micronucleus test can be carried out with mouse spleen cells as well as with cells from bone marrow. Polychromatic erythrocytes occurred in the spleen at a frequency of about 9% of the whole spleen cells compared with about 13% in the bone marrow. 3 test compounds were used to compare the frequency of micronuclei
Y, Shindo +3 more
openaire +2 more sources
The automated bone marrow micronucleus test
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989A new technology is presented which offers high-quality slides enabling the fully automated scoring of large quantities of erythrocytic cells for micronuclei by computerized image analysis. The techniques are applicable to bone marrow specimens as well as to peripheral blood obtained from various species of laboratory animals as well as from man.
F, Romagna, C D, Staniforth
openaire +2 more sources
The micronucleus test: Statistical design and analysis
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979Alternative statistical procedures are discussed which may be employed to compare the incidences among treatment groups of micronucleated polychromatic and normochromatic erythrocytes and their ratios. Comparison of incidences of micronucleated polychromatic erythrocytes using a sequential sampling strategy based on the negative binomial distribution ...
B E, Mackey, J T, MacGregor
openaire +2 more sources
Genetic toxicological testing of some dyes by the micronucleus test
Mutation Research/Genetic Toxicology, 1986Three widely used dyes, acridine orange, blue VRS and fast green FCF were administered to male mice in order to study the induction of gross chromosomal anomalies using the micronucleus test. All 3 compounds were shown to be clastogenic.
R N, Misra, B, Misra
openaire +2 more sources
The Micronucleus Test on Exfoliated Human Cells
1985The frequency of micronuclei in exfoliated human or animal cells can be used as an “endogenous dosimeter” present in tissues which are targets for carcinogenic and genotoxic agents and from which carcinomas arise. The application of the micronucleus test to exfoliated cells of various human tissues will provide evidence of exposure to carcinogens and ...
H F, Stich, W, Stich, M P, Rosin
openaire +2 more sources
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008
The aim of this study was to determine the mechanism of the rodent bone marrow micronucleus test in relation to erythropoiesis. We have previously reported that an acceleration of erythropoiesis increases the frequency of micronucleated polychromatic erythrocytes (MPCE) induced by mutagens.
Yuji, Suzuki +5 more
openaire +2 more sources
The aim of this study was to determine the mechanism of the rodent bone marrow micronucleus test in relation to erythropoiesis. We have previously reported that an acceleration of erythropoiesis increases the frequency of micronucleated polychromatic erythrocytes (MPCE) induced by mutagens.
Yuji, Suzuki +5 more
openaire +2 more sources
Mutation Research/Environmental Mutagenesis and Related Subjects, 1993
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
openaire +2 more sources
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
openaire +2 more sources