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The Micronucleus Test on Exfoliated Human Cells
1985The frequency of micronuclei in exfoliated human or animal cells can be used as an “endogenous dosimeter” present in tissues which are targets for carcinogenic and genotoxic agents and from which carcinomas arise. The application of the micronucleus test to exfoliated cells of various human tissues will provide evidence of exposure to carcinogens and ...
H F, Stich, W, Stich, M P, Rosin
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2014
Mercury, one of the most widely diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states, each of which with unique characteristics of target organ specificity (Aleo et al. 2002). In nature the different forms of mercury include the metallic form, inorganic compounds, as well as alkyl ...
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Mercury, one of the most widely diffused and hazardous organ-specific environmental contaminants, exists in a wide variety of physical and chemical states, each of which with unique characteristics of target organ specificity (Aleo et al. 2002). In nature the different forms of mercury include the metallic form, inorganic compounds, as well as alkyl ...
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Mutation Research/Environmental Mutagenesis and Related Subjects, 1993
In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
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In vivo somatic chromosome mutation tests are usually carried out using the bone marrow micronucleus test in the mouse. This test is also considered predictive for the study of clastogenic effects in germ cells. However, it has been reported that the sensitivity of the bone marrow micronucleus test is insufficient to detect unstable compounds or short ...
I, Cliet, C, Melcion, A, Cordier
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Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2008
The aim of this study was to determine the mechanism of the rodent bone marrow micronucleus test in relation to erythropoiesis. We have previously reported that an acceleration of erythropoiesis increases the frequency of micronucleated polychromatic erythrocytes (MPCE) induced by mutagens.
Yuji, Suzuki +5 more
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The aim of this study was to determine the mechanism of the rodent bone marrow micronucleus test in relation to erythropoiesis. We have previously reported that an acceleration of erythropoiesis increases the frequency of micronucleated polychromatic erythrocytes (MPCE) induced by mutagens.
Yuji, Suzuki +5 more
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Strain difference in the micronucleus test. The Collaborative Study Group for the Micronucleus Test.
Mutation research, 1988The Collaborative Study Group for the Micronucleus Test, a task group of the Environmental Mutagen Society of Japan, has earlier addressed the question of sex difference as a source of variation in the micronucleus test. Strain difference, another issue in test protocols requiring urgent clarification, was selected as the subject of the second study ...
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Strain difference in the micronucleus test
Mutation Research/Genetic Toxicology, 1988Abstract The Collaborative Study Group for the Micronucleus Test, a task group of the Environmental Mutagen Society of Japan, has earlier addressed the question of sex difference as a source of variation in the micronucleus test. Strain difference, another issue in test protocols requiring urgent clarification, was selected as the subject of the ...
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The transplacental micronucleus test
Mutation Research/Environmental Mutagenesis and Related Subjects, 1980C J, Stoyel, A M, Clark
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Sex difference in the micronucleus test. The Collaborative Study Group for the Micronucleus Test.
Mutation research, 1986Since sex difference seemed to be one of the most urgent issues to be clarified among many parameters in protocols for the micronucleus test, the collaborative study group for the micronucleus test, consisting of members of the Japanese Environmental Mutagen Society, focused on this subject first. 20 clastogens were examined for sex-related differences
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The Micronucleus Test for Cytogenetic Analysis
1976Micronuclei originate from chromatin which for different reasons has been lagging in anaphase (Fig. la-d). In the course of telophase this material is included into one or the other daughter cell where it either can fuse with the main nucleus or form one or several secondary nuclei.
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Radioprotective effect of stobadine in the mouse micronucleus test
Mutation Research Letters, 1994Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy 60Co exposure.
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