Evaluation of the safety and functional effects of recombinant humanized type III collagen in food toxicology. [PDF]
Front Med (Lausanne)Zhang Z, Yang W, Yang J, Lan X, Chen C.
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Birds as Environmental Bioindicators of Genotoxicity in Brazilian Cerrado Farmlands: An In Situ Approach. [PDF]
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Early and Late Effects of Difluorodeoxycytidine on Murine Cell Radiosensitivity <i>In Vivo</i>. [PDF]
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Sampling times in micronucleus testing
Mutation Research Letters, 1992A series of micronucleus inducers were evaluated in the mouse bone marrow micronucleus test to determine if a 72-h sampling time enhances the sensitivity for detecting genotoxic agents. Male and female Swiss albino mice were dosed once with 7,12- dimethylbenz[a]anthracene, 6-mercaptopurine, benzo[a]pyrene, benzene, cyclophosphamide, 2 ...
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The micronucleus test methodological aspects
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1973Abstract Changes in the cellular compositiion of bone marrow were studied in relation to dose of Trenimon® and time after treatment. Strong mutagenic effects caused a partial depletion of the marrow cavities of nucleated blood cell precursors, with subsequent retention of newly formed erythrocytes and inundation with peripheral blood.
Von Ledebur, M, Schmid, Werner
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The automated bone marrow micronucleus test
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1989A new technology is presented which offers high-quality slides enabling the fully automated scoring of large quantities of erythrocytic cells for micronuclei by computerized image analysis. The techniques are applicable to bone marrow specimens as well as to peripheral blood obtained from various species of laboratory animals as well as from man.
F, Romagna, C D, Staniforth
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Statistical analysis of the micronucleus test
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1984Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately
G E, Amphlett, G F, Delow
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Effect of erythropoietin on the micronucleus test
Environmental and Molecular Mutagenesis, 1989AbstractThe micronucleus test is used widely as an in vivo short‐term assay for potential carcinogens. In the present study, results of the micronucleus test were affected by the rate of erythropoiesis in the bone marrow erythropoietin, a growth factor for the erythroblast, which was used to induce erythropoiesis.The highest frequency of micronucleated
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