Results 111 to 120 of about 15,524 (254)

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, Volume 268, Issue 4, Page 367-382, April 2026.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

micronucleus test

Citation: 'micronucleus test' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10960 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Analysis of Regulatory Inhalation Unit Risk Estimates for Cobalt: Comparison to Epidemiological Data

Risk Analysis, Volume 46, Issue 4, April 2026.
ABSTRACT Several cancer potency estimates have been proposed by regulatory agencies to characterize the dose response of cobalt and/or cobalt compounds. The objective of this research is to investigate whether these proposed cancer potency estimates for certain cobalt substances align with the available epidemiology literature.
Lynne P. Marshall, Vanessa Viegas, Andrew Maier, Gary Marsh, Marisa L. Kreider   +4 more
wiley   +1 more source

Micronucleus test for determining genotoxic damage

Turkish Bulletin of Hygiene and Experimental Biology, 2011
Micronuclei (MN) are formed during mitosis and do not integrate in the main nucleus. They may arise from a whole lagging chromosome or an acentric chromosome fragment. An increase of MN frequency indicates genomic instability. The MN test is commonly used to determine the genotoxic effects of chemical and physical agents on somatic cells. It is applied
Vedat Sekeroglu, Zulal Atli Sekeroglu
openaire   +1 more source

KIFC1 is Associated With Sarcomatoid Differentiation, Immune Response, and a Poor Prognosis in Clear Cell Renal Cell Carcinoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano, Yohei Sekino, Go Kobayashi, Hikaru Nakahara, Shintaro Akabane, Kenshiro Takemoto, Miki Naito, Shunsuke Miyamoto, Kohei Kobatake, Hiroyuki Kitano, Keisuke Goto, Akihiro Goriki, Keisuke Hieda, Takao Hinoi, Nobuyuki Hinata   +14 more
wiley   +1 more source

Ozonoterapia: efectos genotóxicos en sangre periférica de ratón

Revista Cubana de Investigaciones Biomédicas, 1999
Se realizó el estudio de la actividad genotóxica del oleozón, mediante el ensayo de micronúcleos en sangre periférica, a través del análisis y la comparación de las frecuencias de micronúcleos en reticulocitos en ratones de la línea Cenp:NMRI de uno y ...
Yousy González Carvajal, Antonia Remigio Montero, Zullyt Zamora Rodríguez, Gladys Fonseca López   +3 more
doaj  

The Comet Assay: Tails of the (Un)expected. Use of the comet assay in pharmaceutical development.

Frontiers in Genetics, 2015
In genotoxicity testing of pharmaceuticals the rodent alkaline comet assay is being increasingly used as a second in vivo assay in addition to the in vivo micronucleus assay to mitigate in vitro positive results as recommended by regulatory guidance.
Bas-jan Van Der Leede
doaj   +1 more source

Rapid Adaptation to Road Salts in a Freshwater Microbial Eukaryote

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Road salt application is causing increased salinization of freshwater ecosystems. Using experimental evolution, we demonstrate that ciliates can quickly adapt to tolerate high salinities, but this adaptation may come at a cost to survival in the absence of salt.
Rebecca A. Zufall, Nia Pereda, Karissa Plum, Ethan Rothschild   +3 more
wiley   +1 more source

Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Lead is a nonessential, toxic heavy metal that causes widespread environmental contamination, affecting humans, animals, plants, and ecosystems. Globally, an estimated 800 million children have blood lead levels (BLLs) above 5 µg/dL.
Gudisa Bereda
wiley   +1 more source

Genotoxicity and toxicity evaluations of ECF cellulose bleaching effluents using the Allium cepa L. Test

Brazilian Journal of Biology
Toxicity and genotoxicity tests were performed on root cells of Allium cepa in order to evaluate wastewater quality following an ECF cellulose bleaching process.
O. Roa, MC. Yeber, W. Venegas
doaj   +1 more source