Results 121 to 130 of about 195,958 (227)

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 1-15, February 2026.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Acquired brachial cutaneous dyschromatosis

JAAD Case Reports, 2023
Emily Everdell, BA, Thomas Denize, MD, Hensin Tsao, MD, PhD   +2 more
doaj   +1 more source

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis [PDF]

Zhongguo aizheng zazhi
Background and purpose: The microphthalmia-associated transcription factor (MITF) plays a complex role in melanoma pathogenesis and progression. It is known to regulate multiple processes both in melanocytes and melanoma cells.
WANG Tong, SUN Wei, XU Yu, HU Tu, LIU Wanlin, ZHENG Qiongdan, ZOU Zijian, DONG Zirui, MA Wenjie, CHEN Yong
doaj   +1 more source

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Renal cell carcinoma (RCC) presents a significant global health challenge, with a substantial proportion of patients diagnosed with advanced or metastatic disease due to the limitations of current diagnostic imaging and the lack of validated non‐invasive biomarkers.
Hossam Kamli, Najeeb Ullah Khan
wiley   +1 more source

Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies [PDF]

, 2019
Melasma is an acquired hyperpigmentation disorder most commonly affecting females with darker skin types. It is triggered by several factors including sun exposure, genetic influences, and female sex hormones.
Maymone, Mayra BC de Castro, Rajanala, Susruthi, Vashi, Neelam A   +2 more
core  

Efficacy of Microneedle Fractional Radiofrequency Combined With Platelet‐Rich Plasma for the Treatment of Melasma: A Split‐Face, Randomized Trial

Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.
ABSTRACT Background Melasma is a common facial pigmentary disorder that markedly impairs quality of life, yet current treatments often yield incomplete clearance and frequent relapse. Microneedle fractional radiofrequency (MFR) can remodel the dermis and enhance transdermal delivery, whereas platelet‐rich plasma (PRP) provides growth factors that may ...
Ziyan Chen, Yuhao Li, Yi Ou, Tingqiao Chen, Yangmei Chen, Jin Chen   +5 more
wiley   +1 more source

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

Cell Reports, 2017
The presence of dark melanin (eumelanin) within human epidermis represents one of the strongest predictors of low skin cancer risk. Topical rescue of eumelanin synthesis, previously achieved in “redhaired” Mc1r-deficient mice, demonstrated significant ...
Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher   +13 more
doaj   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

Melphalan modifies the bone microenvironment by enhancing osteoclast formation [PDF]

, 2017
Melphalan is a cytotoxic chemotherapy used to treat patients with multiple myeloma (MM). Bone resorption by osteoclasts, by remodeling the bone surface, can reactivate dormant MM cells held in the endosteal niche to promote tumor development.
Baldock, Brown, Choi, Cobb, Croucher, Dunstan, Gertz, Gillespie, Hamilton, Jemal, Kanagawa, Limaye, Martin, Martin, McCarty, Parfitt, Price, Quinn, Quinn Julian, Reagan, Rizzoli, Rosiñol, Schneider, Sexton, Thompson, Toyama, Zannettino   +26 more
core   +4 more sources

Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis [PDF]

, 2015
The self-organized morphogenesis of the vertebrate optic cup entails coupling the activation of the retinal gene regulatory network to the constriction-driven infolding of the retinal epithelium.
A Galy, A Picker, A Picker, A Woolfe, AM Clark, AP Lee, BE Bernstein, BK Chauhan, BK Chauhan, BM Lane, C Pittack, C Zou, DJ Horsford, E Ferda Percin, EA Schmitt, F Mertes, GG Loots, I Ovcharenko, IS Liu, J Bessa, J Hyer, J Sprague, J Zlotogora, JR Martinez-Morales, JR Martinez-Morales, JR Martinez-Morales, JR Martinez-Morales, K Bharti, KA Frazer, KM Dorval, KM Kwan, M Burmeister, M Eiraku, M Rembold, M Schwarz, M Vitorino, MA Larkin, MT Nguyen, N Harmston, ND Heintzman, NS Dhomen, O Bogdanovic, O Bogdanovic, P Schook, PH Mathers, R Adler, R Sinn, RD Knight, RE Straub, S Fuhrmann, S Reichman, S Rowan, SJ Davies, SJ England, SK Sundaram, SM Barabino, SR Hilfer, T Nakano, T Ohnishi, TF Plageman Jr., TF Plageman Jr., TH Kim, TR Burglin, TS Mikkelsen, VV Osipov, WA Harris, Y Shen   +66 more
core   +1 more source