Results 101 to 110 of about 9,717,047 (191)

Ethanolic Extract of Caulerpa racemosa Inhibits Melanogenesis via Downregulation of Microphthalmia-Associated Transcription Factor and Activation of Extracellular Signal-Regulated Kinase

Cosmetics
The application of natural bioactive compounds in cosmeceutical products, particularly as skin-lightening agents, has received increasing interest. Caulerpa racemosa, a green macroalga of the Chlorophyta division, contains beneficial nutrients that are ...
Ratchanon Sukprasert, Kant Sangpairoj, Pornpun Vivithanaporn, Nongnuch Luangpon, Waranurin Yisarakun, Montakan Tamtin, Witoon Khawsuk, Tanapan Siangcham   +7 more
doaj   +1 more source

Identification of novel genes regulating the development of the palate

Developmental Dynamics, Volume 255, Issue 8, Page 808-823, August 2026.
Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley   +1 more source

Autophagy Modulation in Cancer Therapy: Navigating the Dual Roles to Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Autophagy is a fundamental cellular recycling mechanism with complex and often opposing roles in cancer, functioning as both a tumor suppressor and a pro‐survival mechanism in established tumors. This duality has attracted considerable attention, particularly regarding the therapeutic modulation of autophagy to overcome ...
Md Mohiuddin, Md Al Mamun Ahsan
wiley   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T, Webb, Shaun, Barrass, J David, Beggs, Jean D   +3 more
core   +1 more source

sj-docx-1-npx-10.1177_1934578X221076647 - Supplemental material for Synthesis and Melanogenesis Effect of 7,8-Dimethoxy-4-Methylcoumarin via MAPK Signaling-Mediated Microphthalmia-Associated Transcription Factor Upregulation

, 2022
Supplemental material, sj-docx-1-npx-10.1177_1934578X221076647 for Synthesis and Melanogenesis Effect of 7,8-Dimethoxy-4-Methylcoumarin via MAPK Signaling-Mediated Microphthalmia-Associated Transcription Factor Upregulation by Min-Sung Kang, Sung-Chan ...
Seung-Young Kim (681232), Min-Sung Kang (201832), Min-Seon Kim (107479), Taejin Park (3607148), Jin-Soo Park (1508449), Won-Jae Chi (11050563), Sung-Chan Jang (7623821)   +6 more
core   +1 more source

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

Cell Reports, 2017
The presence of dark melanin (eumelanin) within human epidermis represents one of the strongest predictors of low skin cancer risk. Topical rescue of eumelanin synthesis, previously achieved in “redhaired” Mc1r-deficient mice, demonstrated significant ...
Nisma Mujahid, Yanke Liang, Ryo Murakami, Hwan Geun Choi, Allison S. Dobry, Jinhua Wang, Yusuke Suita, Qing Yu Weng, Jennifer Allouche, Lajos V. Kemeny, Andrea L. Hermann, Elisabeth M. Roider, Nathanael S. Gray, David E. Fisher   +13 more
doaj   +1 more source

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population [PDF]

, 2008
Background Recent studies have implicated variants of the transcription factor 7-like 2 (TCF7L2) gene in genetic susceptibility to type 2 diabetes mellitus in several different populations. The aim of this study was to determine whether variants of this
Barnett Anthony H, Barnett, Anthony, Britten, Abigail C., Bellary, S, Barnett, Anthony H., Anthony H Barnett, Kumar Sudhesh, Britten, Abigail, Sudhesh Kumar, Rees, Simon D., Rees, Simon, Kelly, M. Ann, Kelly, Marilyn, Britten Abigail C, Kelly M Ann, Bellary, Srikanth, Rees Simon D, Srikanth Bellary, Abigail C Britten, J Paul O'Hare, Bellary Srikanth, O'Hare, JP, Kumar, Sudhesh, Simon D Rees, Barnett, A. H., O'Hare J Paul, Kumar, S, O'Hare, J. Paul, M Ann Kelly   +28 more
core   +2 more sources

Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin [PDF]

, 2006
Epithelial tight junctions participate in the regulation of gene expression by controlling the activity of transcription factors that can interact with junctional components.
Choquet, A, Balda, MS, Hollande, F, Matter, K, Tsapara, A, Kavanagh, E, Buchert, M   +6 more
core  

Microenvironment-Driven Dynamic Heterogeneity and Phenotypic Plasticity as a Mechanism of Melanoma Therapy Resistance

Frontiers in Oncology, 2018
Drug resistance constitutes a major challenge in designing melanoma therapies. Microenvironment-driven tumor heterogeneity and plasticity play a key role in this phenomenon. Melanoma is highly heterogeneous with diverse genomic alterations and expression
Farzana Ahmed, Nikolas K. Haass, Nikolas K. Haass   +2 more
doaj   +1 more source

Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: a negative regulator of melanogenesis

, 2012
How signaling via reactive oxygen species (ROS) influences skin pigmentation is unclear. We have investigated how NADPH oxidase-derived ROS modulates the expression of the key pigment "melanin" synthesizing enzymes in B16 mouse melanoma cells.
Dusting, GJ (15629489), Brewer, AC (15664358), Chang, CW (15664361), Higuchi, M (15664007), Chan, EC (15663968), Peshavariya, H (15664217), Guei-Sheung Liu (14742562)   +6 more
core