Results 81 to 90 of about 9,717,047 (191)

MicroRNA-137 Targets Microphthalmia-Associated Transcription Factor in Melanoma Cell Lines [PDF]

Cancer Research, 2008
Abstract Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function. Frequent alteration in the expression of MITF is detected in melanoma, but the mechanism(s) underlying the alteration in expression have not been completely determined.
Lynne T, Bemis, Robert, Chen, Carol M, Amato, Elizabeth H, Classen, Steven E, Robinson, David G, Coffey, Paul F, Erickson, Yiqun G, Shellman, William A, Robinson   +8 more
openaire   +2 more sources

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

, 2013
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer.
Segura, Miguel F., Álvarez-Díaz, S., Hernando, Eva   +2 more
core   +1 more source

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype

JCI Insight, 2022
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states.
Adriana Sanna, Bengt Phung, Shamik Mitra, Martin Lauss, Jiyeon Choi, Tongwu Zhang, Ching-Ni Njauw, Eugenia Cordero, Katja Harbst, Frida Rosengren, Rita Cabrita, Iva Johansson, Karolin Isaksson, Christian Ingvar, Ana Carneiro, Kevin Brown, Hensin Tsao, My Andersson, Kristian Pietras, Göran Jönsson   +19 more
doaj   +1 more source

CHARGE Syndrome: A Narrative Review and Update on Diagnosis, Assessment and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background CHARGE syndrome (CS) is a rare multisystemic genetic condition caused by a pathogenic variant in the DNA‐binding protein‐7 CHD7 gene. The condition affects the development of neural crest cells, which give rise to craniofacial structures, cranial nerves, ears, eyes and the heart, resulting in diverse and complex clinical features ...
Eleni M. van Gelder, Suzanna E. L. Temple, Niall Jefferson, David Brown, Kasee Stratton‐Gadke, Madelene Rich, Steve Rose, Kim Blake   +7 more
wiley   +1 more source

Cutis Tricolor‐Like Pigmentary Mosaicism in Mowat–Wilson Syndrome: Phenotypic Overlap With Ruggieri–Happle Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Cutis tricolor (CT) is a rare pigmentary mosaicism characterized by the coexistence of hyperpigmented and hypopigmented areas on a background of normal skin; its syndromic form, Ruggieri–Happle syndrome (RHS), is associated with neurodevelopmental delay, facial dysmorphism, skeletal abnormalities, and other systemic defects.
Didier Bessis, Pierre Meyer, Marjolaine Willems   +2 more
wiley   +1 more source

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Ayuko Takahashi (789901), Barbara D. Smith (2212672), Takahashi, A, Christopher Denton, Layne, MD, Bahja Ahmed-Abdi, Ayuko Takahashi, Suki, B, Nikitorowicz-Buniak, J, Bela Suki (2212681), Bahja Ahmed-Abdi (2212675), Matthew D. Layne (364786), Markella Ponticos, Ahmed-Abdi, B, Robert Lafyatis, Markella Ponticos (2212669), Xu Shiwen (2212678), Stratton, R, Bela Suki, Barbara D Smith, Richard Stratton (776213), Joanna Nikitorowicz-Buniak (776212), Smith, BD, Christopher Denton (276245), Xu Shiwen, Lafyatis, R, David Abraham (36404), Shiwen, X, David Abraham, Abraham, D, Matthew D Layne, Ponticos, M, Denton, C, Joanna Nikitorowicz-Buniak, Robert Lafyatis (38139), Richard Stratton   +35 more
core   +1 more source

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis [PDF]

Zhongguo aizheng zazhi
Background and purpose: The microphthalmia-associated transcription factor (MITF) plays a complex role in melanoma pathogenesis and progression. It is known to regulate multiple processes both in melanocytes and melanoma cells.
Tong WANG, Wei SUN, Yu XU, Tu HU, Wanlin LIU, Qiongdan ZHENG, Zijian ZOU, Zirui DONG, Wenjie MA, Yong CHEN   +9 more
doaj   +2 more sources

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

eLife, 2015
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interactome
Patrick Laurette, Thomas Strub, Dana Koludrovic, Céline Keime, Stéphanie Le Gras, Hannah Seberg, Eric Van Otterloo, Hana Imrichova, Robert Siddaway, Stein Aerts, Robert A Cornell, Gabrielle Mengus, Irwin Davidson   +12 more
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source