Results 1 to 10 of about 16,424 (119)

Whole-Exome Sequencing Reveals Pediatric Rare Syndromic Hearing Loss

罕见病研究, 2022
Objective To discuss the significance of genetic diagnosis of children with syndromic hearing loss by using whole-exome sequencing. Methods The clinical data of 34 children with sensorineural hearing loss were collected and the whole exons of genome of ...
QU Chunyan, ZHOU Yi, CHEN Min, HAO Jinsheng, NI Xin, LIU Haihong   +5 more
doaj   +1 more source

Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells

Journal for ImmunoTherapy of Cancer, 2023
Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon, Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Young Yang, Myeong-Sok Lee, Jong-Seok Lim   +8 more
doaj   +1 more source

Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

eLife, 2019
Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses ...
Alec K Gramann, Arvind M Venkatesan, Melissa Guerin, Craig J Ceol   +3 more
doaj   +1 more source

The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300

Scientific Reports, 2023
The microphthalmia-associated transcription factor (MITF) is one of four closely related members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular processes.
Alexandra D. Brown, Kyle Lynch, David N. Langelaan   +2 more
doaj   +1 more source

Deubiquitination of MITF-M Regulates Melanocytes Proliferation and Apoptosis

Frontiers in Molecular Biosciences, 2021
Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post-translation modifications.
Shuaishuai Hu, Shaocheng Bai, Yingying Dai, Naisu Yang, Jiali Li, Xiyu Zhang, Fan Wang, Bohao Zhao, Guolian Bao, Yang Chen, Yang Chen, Xinsheng Wu, Xinsheng Wu   +12 more
doaj   +1 more source

Deregulated MITF sumoylation: A route to melanoma

Molecular & Cellular Oncology, 2017
Metastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival.
Robert Ballotti, Corine Bertolotto
doaj   +1 more source

MiTF links Erk1/2 kinase and p21^CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells

Molecular Cancer, 2010
As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown.
Liu Feng, Singh Amarinder, Yang Zhen, Garcia Angela, Kong Yu, Meyskens Frank L   +5 more
doaj   +1 more source

An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis

Biomedicines, 2023
Background: Sepsis induces GAS5 expression in the vascular endothelium, but the molecular mechanism is unclear, as is the role of GAS5 in sepsis. Methods and results: We observed that GAS5 expression in the endothelium was significantly upregulated in a ...
Junning Cheng, Chang Ding, Huying Tang, Haonan Zhou, Mingdong Wu, Yikuan Chen   +5 more
doaj   +1 more source

HVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma

OncoImmunology, 2019
HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading antitumor immunity.
Nausicaa Malissen, Nicolas Macagno, Samuel Granjeaud, Clémence Granier, Vincent Moutardier, Caroline Gaudy-Marqueste, Nadia Habel, Marion Mandavit, Bernard Guillot, Christine Pasero, Eric Tartour, Robert Ballotti, Jean-Jacques Grob, Daniel Olive   +13 more
doaj   +1 more source

Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. [PDF]

PLoS ONE, 2017
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340.
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee   +2 more
doaj   +1 more source