Results 1 to 10 of about 16,371 (189)
Deregulated MITF sumoylation: A route to melanoma [PDF]
Molecular & Cellular Oncology, 2017 Metastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival.
Robert Ballotti, Corine Bertolotto
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Deubiquitination of MITF-M Regulates Melanocytes Proliferation and Apoptosis
Frontiers in Molecular Biosciences, 2021 Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post-translation modifications.
Shaocheng Bai, Naisu Yang, Bohao Zhao
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Journal of Investigative Dermatology, 2002 Microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix (bHLH) and bHLH-leucine zipper transcription factor, is currently an intense focal point in pigment cell biology research. MITF is implicated as the master gene for survival of melanocytes, as well as a key transcription factor regulating the expression of major melanogenic
Park, Hee-Young, Gilchrest, Barbara A.
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Genes & Development, 2019 All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of melanocyte and melanoma biology. Like all transcription factors, MITF binds to specific DNA sequences and up-
Goding, C, Arnheiter, H
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Journal for ImmunoTherapy of Cancer, 2023 Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon +8 more
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The
Pigment Cell & Melanoma Research, 2022 AbstractBidirectional interactions between plastic tumor cells and the microenvironment critically impact tumor evolution and metastatic dissemination by enabling cancer cells to adapt to microenvironmental stresses by switching phenotype. In melanoma, a key determinant of phenotypic identity is the microphthalmia‐associated transcription factor MITF ...
Chauhan, JS +4 more
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The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300
Scientific Reports, 2023 The microphthalmia-associated transcription factor (MITF) is one of four closely related members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular processes.
Alexandra D. Brown +2 more
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Whole-Exome Sequencing Reveals Pediatric Rare Syndromic Hearing Loss
罕见病研究, 2022 Objective To discuss the significance of genetic diagnosis of children with syndromic hearing loss by using whole-exome sequencing. Methods The clinical data of 34 children with sensorineural hearing loss were collected and the whole exons of genome of ...
QU Chunyan +5 more
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Pro-Survival Role of MITF in Melanoma [PDF]
Journal of Investigative Dermatology, 2015 Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell survival. Although components of melanoma cytoprotective mechanisms are overexpressed in many types of tumors, some of their regulators are characteristic for melanoma.
Hartman, Mariusz L., Czyz, Malgorzata
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Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling
eLife, 2019 Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses ...
Alec K Gramann +3 more
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