Results 21 to 30 of about 16,506 (196)

MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway

Frontiers in Immunology, 2023
MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been
Yanru Guo, Yanru Guo, Laia Ollé, Laia Ollé, Elizabeth Proaño-Pérez, Elizabeth Proaño-Pérez, Elizabeth Proaño-Pérez, Cristina Aparicio, Mario Guerrero, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Margarita Martín, Margarita Martín, Margarita Martín   +14 more
doaj   +1 more source

Curcuma longa L. (Zingiberaceae) extract protects against epithelial damage and reduces the expression of the microphthalmia-associated transcription factor in UVB-exposed Wistar rats [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Disproportionate subjection to solar ultraviolet B (UVB) radiation may alter the physiology of human skin. Microphthalmia-associated transcription factor (MITF) is the principal regulator of melanogenesis in the skin.
Deni Firmansyah, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita   +3 more
doaj   +1 more source

Mitf Induction by RANKL Is Critical for Osteoclastogenesis [PDF]

Molecular Biology of the Cell, 2010
Microphthalmia-associated transcription factor (Mitf) regulates the development and function of several cell lineages, including osteoclasts. In this report, we identified a novel mechanism by which RANKL regulates osteoclastogenesis via induction of Mitf isoform E (Mitf-E). Both Mitf-A and Mitf-E are abundantly present in osteoclasts.
Lu, Ssu-Yi, Li, Mengtao, Lin, Yi-Ling
openaire   +2 more sources

Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells

eLife, 2015
Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interactome
Patrick Laurette, Thomas Strub, Dana Koludrovic, Céline Keime, Stéphanie Le Gras, Hannah Seberg, Eric Van Otterloo, Hana Imrichova, Robert Siddaway, Stein Aerts, Robert A Cornell, Gabrielle Mengus, Irwin Davidson   +12 more
doaj   +1 more source

Subcellular localization of Mitf in monocytic cells [PDF]

Histochemistry and Cell Biology, 2010
Microphthalmia-associated transcription factor (Mitf) is a transcription factor that plays an important role in regulating the development of several cell lineages. The subcellular localization of Mitf is dynamic and is associated with its transcription activity.
Lu, Ssu-Yi, Wan, Hsiao-Ching, Li, Mengtao, Lin, Yi-Ling   +3 more
openaire   +4 more sources

Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. [PDF]

PLoS ONE, 2008
The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells. MITF is essential for the survival of pigmented cells, but whereas high levels of MITF drive melanocyte ...
Claudia Wellbrock, Sareena Rana, Hugh Paterson, Helen Pickersgill, Thijn Brummelkamp, Richard Marais   +5 more
doaj   +1 more source

MITF Contributes to the Body Color Differentiation of Sea Cucumbers Apostichopus japonicus through Expression Differences and Regulation of Downstream Genes

Biology, 2022
Melanin, which is a pigment produced in melanocytes, is an important contributor to sea cucumber body color. MITF is one of the most critical genes in melanocyte development and melanin synthesis pathways.
Lili Xing, Shilin Liu, Libin Zhang, Hongsheng Yang, Lina Sun   +4 more
doaj   +1 more source

MD investigation on the binding of microphthalmia-associated transcription factor with DNA

Journal of Saudi Chemical Society, 2022
As a main regulator of melanocyte development and an key melanoma oncogene, microphthalmia-associated transcription factor (MITF) is one of the proteins in the basic helix-loop-helix zipper (bHLHZip) transcription factor family. The study on the detailed
Xiang-Feng Wang, Jian Sun, Xin-Lu Wang, Jia-Kun Tian, Zhen-Wei Tian, Ji-Long Zhang, Ran Jia   +6 more
doaj   +1 more source

Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma

Translational Oncology, 2019
Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold   +10 more
doaj   +1 more source

Expression and contribution of microphthalmia-associated transcription factor to the melanin deposition in Liancheng white ducks

Journal of Integrative Agriculture, 2020
The present study investigates the expression of microphthalmia-associated transcription factor (MITF) and its contribution to the melanin deposition in Liancheng white ducks.
Qing-wu XIN, Zhong-wei MIAO, Zhao-yuan LIU, Li LI, Lin-li ZHANG, Zhi-ming ZHU, Zheng-hong ZHANG, Nen-zhu ZHENG, Zheng-chao WANG   +8 more
doaj   +1 more source