Results 41 to 50 of about 21,203 (224)

Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines. [PDF]

PLoS ONE, 2017
ILEI (FAM3C) is a secreted factor that contributes to the epithelial-to-mesenchymal transition (EMT), a cell biological process that confers metastatic properties to a tumor cell.
Ken Noguchi, Annamarie C Dalton, Breege V Howley, Buckley J McCall, Akihiro Yoshida, J Alan Diehl, Philip H Howe   +6 more
doaj   +1 more source

MITF Contributes to the Body Color Differentiation of Sea Cucumbers Apostichopus japonicus through Expression Differences and Regulation of Downstream Genes

Biology, 2022
Melanin, which is a pigment produced in melanocytes, is an important contributor to sea cucumber body color. MITF is one of the most critical genes in melanocyte development and melanin synthesis pathways.
Lili Xing, Shilin Liu, Libin Zhang, Hongsheng Yang, Lina Sun   +4 more
doaj   +1 more source

Expression and contribution of microphthalmia-associated transcription factor to the melanin deposition in Liancheng white ducks

Journal of Integrative Agriculture, 2020
The present study investigates the expression of microphthalmia-associated transcription factor (MITF) and its contribution to the melanin deposition in Liancheng white ducks.
Qing-wu XIN, Zhong-wei MIAO, Zhao-yuan LIU, Li LI, Lin-li ZHANG, Zhi-ming ZHU, Zheng-hong ZHANG, Nen-zhu ZHENG, Zheng-chao WANG   +8 more
doaj   +1 more source

BPTF transduces MITF-driven prosurvival signals in melanoma cells [PDF]

, 2016
Microphthalmia-associated transcription factor (MITF) plays a critical and complex role in melanocyte transformation. Although several downstream targets of MITF action have been identified, the precise mechanisms by which MITF promotes melanocytic tumor
Miller, James R, Debs, Robert, Bezrookove, Vladimir, Dar, Altaf A, Sagebiel, Richard W, Kashani-Sabet, Mohammed, Majid, Shahana, Cleaver, James E, Nosrati, Mehdi, De Semir, David, Phan, Binh, Ursu, Sarah   +11 more
core   +1 more source

Ónæmisforðun MITF-low-sortuæxlisfrumna: Hlutverk IFN-γ og viðbragðsþátta þess

, 2022
Inngangur: Sortuæxlisfrumur geta komið sér undan krabbameinsvörnum ónæmiskerfisins með tjáningu ónæmisbæliprótína. Eitt slíkt prótín, PD-L1, er, skv. óbirtum niðurstöðum frá rannsóknarstofunni okkar, hlutfallslega meira tjáð í IFN-γ-meðhöndluðum MITF-low-
Ólafur Cesarsson 2000-
core   +1 more source

microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. [PDF]

PLoS ONE, 2015
Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein ...
Nathalie Arts, Stefania Cané, Marc Hennequart, Juliette Lamy, Guido Bommer, Benoît Van den Eynde, Etienne De Plaen   +6 more
doaj   +1 more source

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

YY1 interacts with MITF.

, 2012
(A) Interaction between Flag-tagged YY1 and HA-tagged M-MITF in 293T cells. Total cell lysate of 293T cells transfected with indicated plasmids was immunoprecipitated with anti-Flag M2 agarose beads.
Daniel G. Anderson (166832), Robert Langer (166824), Juying Li (166780), Kevin T. Love (166814), Lionel Larue (166841), David E. Fisher (166846), Robert J. A. Bell (166785), Thanh-Nga T. Tran (166787), Huifei Liu (166804), Rizwan Haq (166796), Jun S. Song (166783)   +10 more
core   +1 more source

Acetylation reprograms MITF target selectivity and residence time

Nature Communications, 2023
The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis.
Pakavarin Louphrasitthiphol, Alessia Loffreda, Vivian Pogenberg, Sarah Picaud, Alexander Schepsky, Hans Friedrichsen, Zhiqiang Zeng, Anahita Lashgari, Benjamin Thomas, E. Elizabeth Patton, Matthias Wilmanns, Panagis Filippakopoulos, Jean-Philippe Lambert, Eiríkur Steingrímsson, Davide Mazza, Colin R. Goding   +15 more
doaj   +1 more source

Attenuation Effect of Radiofrequency Irradiation on UV-B-Induced Skin Pigmentation by Decreasing Melanin Synthesis and through Upregulation of Heat Shock Protein 70

Molecules, 2021
Excess melanin deposition in the skin causes cosmetic problems. HSP70 upregulation decreases microphthalmia-associated transcription factor (MITF) expression, which eventually decreases tyrosinase activity and melanogenesis.
Hyoung Moon Kim, Seyeon Oh, Chang Hu Choi, Jin Young Yang, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source