Isolation, Structural Elucidation, and Anti-Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch. [PDF]
Chem BiodiversPolysaccharide extraction from Alhagi camelorum Fisch. was optimized, yielding ACP‐II‐1, a novel GalA‐rich, HG‐dominant pectin (26.145 kDa) containing branched RG‐I domains. ACP‐II‐1 reduced melanogenesis in forskolin‐stimulated B16F10 cells and a zebrafish model.
Liu Z +4 more
europepmc +2 more sources
Cochlear Melanocytes and MITF Signaling [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2001 Melanocytes occur not only in the skin and eyes but in the cochlea, where they exist as intermediate cells of the stria vascularis. Intermediate cells play an important role for cochlear function: Na+K+-ATPase and potassium channels of intermediate cells are essential for production of endocochlear potential and for preparation of ionic milieu in the ...
openaire +2 more sources
Curcuma longa L. (Zingiberaceae) extract protects against epithelial damage and reduces the expression of the microphthalmia-associated transcription factor in UVB-exposed Wistar rats [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Disproportionate subjection to solar ultraviolet B (UVB) radiation may alter the physiology of human skin. Microphthalmia-associated transcription factor (MITF) is the principal regulator of melanogenesis in the skin.
Deni Firmansyah +3 more
doaj +1 more source
MD investigation on the binding of microphthalmia-associated transcription factor with DNA
Journal of Saudi Chemical Society, 2022 As a main regulator of melanocyte development and an key melanoma oncogene, microphthalmia-associated transcription factor (MITF) is one of the proteins in the basic helix-loop-helix zipper (bHLHZip) transcription factor family. The study on the detailed
Xiang-Feng Wang +6 more
doaj +1 more source
MITF-dependent phenotypic plasticity regulates proton-coupled transport and controls lineage resistance to acidotic stress [PDF]
, 2020 The lineage addiction oncogene, Microphthalmia-Associated Transcription Factor (MITF), mediates melanoma phenotypic plasticity – a pathophysiological process that underlies intratumoural heterogeneity, where melanoma cells interchangeably alter their ...
Yang, Oscar
core +1 more source
Mitf Induction by RANKL Is Critical for Osteoclastogenesis [PDF]
Molecular Biology of the Cell, 2010 Microphthalmia-associated transcription factor (Mitf) regulates the development and function of several cell lineages, including osteoclasts. In this report, we identified a novel mechanism by which RANKL regulates osteoclastogenesis via induction of Mitf isoform E (Mitf-E). Both Mitf-A and Mitf-E are abundantly present in osteoclasts.
Lu, Ssu-Yi, Li, Mengtao, Lin, Yi-Ling
openaire +2 more sources
eLife, 2015 Microphthalmia-associated transcription factor (MITF) is the master regulator of the melanocyte lineage. To understand how MITF regulates transcription, we used tandem affinity purification and mass spectrometry to define a comprehensive MITF interactome
Patrick Laurette +12 more
doaj +1 more source
Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma
Translational Oncology, 2019 Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann +10 more
doaj +1 more source
Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF. [PDF]
PLoS ONE, 2008 The Microphthalmia-associated transcription factor (MITF) is an important regulator of cell-type specific functions in melanocytic cells. MITF is essential for the survival of pigmented cells, but whereas high levels of MITF drive melanocyte ...
Claudia Wellbrock +5 more
doaj +1 more source
Pathways from senescence to melanoma: focus on MITF sumoylation
, 2017 International audienceCutaneous melanoma is a deadly skin cancer that originates from melanocytes. The development of cutaneous melanoma involves a complex interaction between environmental factors, mainly ultraviolet radiation from sunlight, and genetic
C Bertolotto +5 more
core +1 more source