Results 31 to 40 of about 16,371 (189)

microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. [PDF]

PLoS ONE, 2015
Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein ...
Nathalie Arts, Stefania Cané, Marc Hennequart, Juliette Lamy, Guido Bommer, Benoît Van den Eynde, Etienne De Plaen   +6 more
doaj   +1 more source

Expression and contribution of microphthalmia-associated transcription factor to the melanin deposition in Liancheng white ducks

Journal of Integrative Agriculture, 2020
The present study investigates the expression of microphthalmia-associated transcription factor (MITF) and its contribution to the melanin deposition in Liancheng white ducks.
Qing-wu XIN, Zhong-wei MIAO, Zhao-yuan LIU, Li LI, Lin-li ZHANG, Zhi-ming ZHU, Zheng-hong ZHANG, Nen-zhu ZHENG, Zheng-chao WANG   +8 more
doaj   +1 more source

Acetylation reprograms MITF target selectivity and residence time

Nature Communications, 2023
The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis.
Pakavarin Louphrasitthiphol, Alessia Loffreda, Vivian Pogenberg, Sarah Picaud, Alexander Schepsky, Hans Friedrichsen, Zhiqiang Zeng, Anahita Lashgari, Benjamin Thomas, E. Elizabeth Patton, Matthias Wilmanns, Panagis Filippakopoulos, Jean-Philippe Lambert, Eiríkur Steingrímsson, Davide Mazza, Colin R. Goding   +15 more
doaj   +1 more source

Regulation of MITF stability by the USP13 deubiquitinase [PDF]

Nature Communications, 2011
The microphthalmia-associated transcription factor (MITF) is essential for melanocyte development. Mutation-induced MAPK pathway activation is common in melanoma and induces MITF phosphorylation, ubiquitination, and proteolysis. Little is known about the enzymes involved in MITF ubiquitination/deubiquitination.
Xiansi, Zhao, Brian, Fiske, Akinori, Kawakami, Juying, Li, David E, Fisher   +4 more
openaire   +2 more sources

Attenuation Effect of Radiofrequency Irradiation on UV-B-Induced Skin Pigmentation by Decreasing Melanin Synthesis and through Upregulation of Heat Shock Protein 70

Molecules, 2021
Excess melanin deposition in the skin causes cosmetic problems. HSP70 upregulation decreases microphthalmia-associated transcription factor (MITF) expression, which eventually decreases tyrosinase activity and melanogenesis.
Hyoung Moon Kim, Seyeon Oh, Chang Hu Choi, Jin Young Yang, Sunggeun Kim, Donghwan Kang, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours [PDF]

PeerJ, 2015
CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the ‘proliferative’ from ‘invasive’ signature in the phenotype-switching model of melanoma. We have found that, in addition to other ‘proliferative’ signature genes,
Jillian Howlin, Helena Cirenajwis, Barbara Lettiero, Johan Staaf, Martin Lauss, Lao Saal, Åke Borg, Sofia Gruvberger-Saal, Göran Jönsson   +8 more
doaj   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

05 | Revisiting cancer risk associated with the MITF p.e318k variant beyond melanoma

Dermatology Reports
Background: The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele.
Italian Melanoma Intergroup
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source