Results 11 to 20 of about 16,371 (189)

Clinical, pathological and dermoscopic phenotype of MITF p.E318K carrier cutaneous melanoma patients

Journal of Translational Medicine, 2020
Background The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on clinico-phenotypic, as well as on
Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta, Paola Ghiorzo, Italian Melanoma Intergroup (I.M.I.)   +15 more
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Mitf Induction by RANKL Is Critical for Osteoclastogenesis [PDF]

Molecular Biology of the Cell, 2010
Microphthalmia-associated transcription factor (Mitf) regulates the development and function of several cell lineages, including osteoclasts. In this report, we identified a novel mechanism by which RANKL regulates osteoclastogenesis via induction of Mitf isoform E (Mitf-E). Both Mitf-A and Mitf-E are abundantly present in osteoclasts.
Lu, Ssu-Yi, Li, Mengtao, Lin, Yi-Ling
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MiTF links Erk1/2 kinase and p21^CIP1/WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells

Molecular Cancer, 2010
As a survival factor for melanocytes lineage cells, MiTF plays multiple roles in development and melanomagenesis. What role MiTF plays in the DNA damage response is currently unknown.
Liu Feng, Singh Amarinder, Yang Zhen, Garcia Angela, Kong Yu, Meyskens Frank L   +5 more
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An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis

Biomedicines, 2023
Background: Sepsis induces GAS5 expression in the vascular endothelium, but the molecular mechanism is unclear, as is the role of GAS5 in sepsis. Methods and results: We observed that GAS5 expression in the endothelium was significantly upregulated in a ...
Junning Cheng, Chang Ding, Huying Tang, Haonan Zhou, Mingdong Wu, Yikuan Chen   +5 more
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HVEM has a broader expression than PD-L1 and constitutes a negative prognostic marker and potential treatment target for melanoma

OncoImmunology, 2019
HVEM (Herpes Virus Entry Mediator) engagement of BTLA (B and T Lymphocyte Attenuator) triggers inhibitory signals in T cells and could play a role in evading antitumor immunity.
Nausicaa Malissen, Nicolas Macagno, Samuel Granjeaud, Clémence Granier, Vincent Moutardier, Caroline Gaudy-Marqueste, Nadia Habel, Marion Mandavit, Bernard Guillot, Christine Pasero, Eric Tartour, Robert Ballotti, Jean-Jacques Grob, Daniel Olive   +13 more
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Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. [PDF]

PLoS ONE, 2017
Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340.
Gerrit van Rensburg, Sebastian Mackedenski, Chow H Lee   +2 more
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MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway

Frontiers in Immunology, 2023
MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been
Yanru Guo, Yanru Guo, Laia Ollé, Laia Ollé, Elizabeth Proaño-Pérez, Elizabeth Proaño-Pérez, Elizabeth Proaño-Pérez, Cristina Aparicio, Mario Guerrero, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Rosa Muñoz-Cano, Margarita Martín, Margarita Martín, Margarita Martín   +14 more
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A rare case of Waardenburg syndrome with unilateral hearing loss caused by nonsense variant c.772C>T (p.Arg259*) in the MITF gene in Yakut patient from the Eastern Siberia (Sakha Republic, Russia)

International Journal of Circumpolar Health, 2019
Waardenburg syndrome (WS) is an orphan genetic disease with autosomal dominant pattern of inheritance characterised by varying degrees of hearing loss accompanied by skin, hair and iris pigmentation abnormalities. Four types of WS differing in phenotypic
Nikolay A. Barashkov, Georgii P. Romanov, Uigulaana P. Borisova, Aisen V. Solovyev, Vera G. Pshennikova, Fedor M. Teryutin, Alexander A. Bondar, Igor V. Morozov, Elza K. Khusnutdinova, Olga L. Posukh, Tatiana E. Burtseva, Jon Øyvind Odland, Sardana A. Fedorova   +12 more
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MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells. [PDF]

PLoS ONE, 2013
Metastasized malignant melanoma has a poor prognosis because of its intrinsic resistance to chemotherapy and radiotherapy. The central role in the melanoma transcriptional network has the transcription factor MITF (microphthalmia-associated transcription
Lubica Ondrušová, Jiri Vachtenheim, Jiri Réda, Petra Záková, Kamila Benková   +4 more
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Cochlear Melanocytes and MITF Signaling [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2001
Melanocytes occur not only in the skin and eyes but in the cochlea, where they exist as intermediate cells of the stria vascularis. Intermediate cells play an important role for cochlear function: Na+K+-ATPase and potassium channels of intermediate cells are essential for production of endocochlear potential and for preparation of ionic milieu in the ...
openaire   +2 more sources