Results 11 to 20 of about 21,203 (224)

MITF—the first 25 years [PDF]

Genes & Development, 2019
All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of ...
Colin R. Goding, Heinz Arnheiter, Arnheiter, H, Goding, Colin   +3 more
core   +4 more sources

Subcellular localization of Mitf in monocytic cells [PDF]

Histochemistry and Cell Biology, 2010
Microphthalmia-associated transcription factor (Mitf) is a transcription factor that plays an important role in regulating the development of several cell lineages.
Ssu-Yi Lu, Yi-Ling Lin, Li, Mengtao, Hsiao-Ching Wan, Mengtao Li, Lu, Ssu-Yi, Lin, Yi-Ling, Wan, Hsiao-Ching   +7 more
core   +6 more sources

Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease [PDF]

Cancer Research, 2019
The melanocyte-inducing transcription factor (MITF)–low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking.
Spitzer, Michaela, Brown, Daniel V., Dilshat, Ramile, Mathers, Marie E, Ponting, Chris P., Lefevre, Thomas, Ponting, Chris P.; id_orcid, Travnickova, Jana, Patton, E. Elizabeth; id_orcid, Steingrimsson, Eirikur, Mathers, Marie E., Khamseh, Ava, Capper, Amy, Ewing, Ailith, Semple, Colin A.; id_orcid, Semple, Colin A., Lister, James A, Wojciechowska, Sonia, Lister, James A., Patton, E. Elizabeth, Brown, Daniel V, Voet, Thierry, Gautier, Philippe, Brombin, Alessandro   +23 more
core   +4 more sources

Clinical, pathological and dermoscopic phenotype of MITF p.E318K carrier cutaneous melanoma patients [PDF]

Journal of Translational Medicine, 2020
Background The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on clinico-phenotypic, as well as on
Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta, Paola Ghiorzo, Italian Melanoma Intergroup (I.M.I.)   +15 more
doaj   +4 more sources

miR-148 regulates Mitf in melanoma cells.

PLoS ONE, 2010
The Microphthalmia associated transcription factor (Mitf) is an important regulator in melanocyte development and has been shown to be involved in melanoma progression. The current model for the role of Mitf in melanoma assumes that the total activity of
Benedikta S Haflidadóttir, Kristín Bergsteinsdóttir, Christian Praetorius, Eiríkur Steingrímsson   +3 more
doaj   +2 more sources

MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells. [PDF]

PLoS ONE, 2013
Metastasized malignant melanoma has a poor prognosis because of its intrinsic resistance to chemotherapy and radiotherapy. The central role in the melanoma transcriptional network has the transcription factor MITF (microphthalmia-associated transcription
Lubica Ondrušová, Jiri Vachtenheim, Jiri Réda, Petra Záková, Kamila Benková   +4 more
doaj   +2 more sources

CITED1 is a novel binding partner of MITF that influences the MITF-directed transcriptional profile in melanoma

, 2017
We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive
Ake Borg, Jillian Howlin, Martin Lauss, Sofia Gruvberger-Saal, Barbara Lettiero, Goran B Jönsson   +5 more
core   +2 more sources

More On MITF [PDF]

Journal of Investigative Dermatology, 2002
Microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix (bHLH) and bHLH-leucine zipper transcription factor, is currently an intense focal point in pigment cell biology research. MITF is implicated as the master gene for survival of melanocytes, as well as a key transcription factor regulating the expression of major melanogenic
Park, Hee-Young, Gilchrest, Barbara A.
openaire   +2 more sources

MITF-activated genes associated with TFAP2-independent MITF peaks are enriched for cell cycle and DNA-repair.

, 2022
(A) Plot-profile showing MITF CUT&RUN peak signal at TFAP2-independent MITF peaks in TFAP2-KO and WT SK-MEL-28 cell lines. (B) Genes associated with TFAP2-independent anti-MITF peaks were analyzed for enriched gene ontology biological process using GREAT
Hannah E. Seberg (3804376), Gregory Bonde (130382), Christopher M. Franke (12557816), Ramile Dilshat (9029712), Eric Van Otterloo (241891), Eiríkur Steingrímsson (245726), Robert A. Cornell (8933123), Colin Kenny (8830949), Annika Helverson (12557813)   +8 more
core   +1 more source

The MITF regulatory network in melanoma

Pigment Cell & Melanoma Research, 2022
AbstractBidirectional interactions between plastic tumor cells and the microenvironment critically impact tumor evolution and metastatic dissemination by enabling cancer cells to adapt to microenvironmental stresses by switching phenotype. In melanoma, a key determinant of phenotypic identity is the microphthalmia‐associated transcription factor MITF ...
Chauhan, JS, Hölzel, M, Lambert, J-P, Buffa, FM, Goding, CR   +4 more
openaire   +3 more sources