Results 11 to 20 of about 16,506 (196)

More On MITF [PDF]

Journal of Investigative Dermatology, 2002
Microphthalmia-associated transcription factor (MITF), a basic-helix-loop-helix (bHLH) and bHLH-leucine zipper transcription factor, is currently an intense focal point in pigment cell biology research. MITF is implicated as the master gene for survival of melanocytes, as well as a key transcription factor regulating the expression of major melanogenic
Park, Hee-Young, Gilchrest, Barbara A.
openaire   +2 more sources

MITF—the first 25 years [PDF]

Genes & Development, 2019
All transcription factors are equal, but some are more equal than others. In the 25 yr since the gene encoding the microphthalmia-associated transcription factor (MITF) was first isolated, MITF has emerged as a key coordinator of many aspects of melanocyte and melanoma biology. Like all transcription factors, MITF binds to specific DNA sequences and up-
Goding, C, Arnheiter, H
openaire   +2 more sources

The MITF regulatory network in melanoma

Pigment Cell & Melanoma Research, 2022
AbstractBidirectional interactions between plastic tumor cells and the microenvironment critically impact tumor evolution and metastatic dissemination by enabling cancer cells to adapt to microenvironmental stresses by switching phenotype. In melanoma, a key determinant of phenotypic identity is the microphthalmia‐associated transcription factor MITF ...
Chauhan, JS, Hölzel, M, Lambert, J-P, Buffa, FM, Goding, CR   +4 more
openaire   +3 more sources

Pro-Survival Role of MITF in Melanoma [PDF]

Journal of Investigative Dermatology, 2015
Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell survival. Although components of melanoma cytoprotective mechanisms are overexpressed in many types of tumors, some of their regulators are characteristic for melanoma.
Hartman, Mariusz L., Czyz, Malgorzata
openaire   +2 more sources

A rare case of Waardenburg syndrome with unilateral hearing loss caused by nonsense variant c.772C>T (p.Arg259*) in the MITF gene in Yakut patient from the Eastern Siberia (Sakha Republic, Russia)

International Journal of Circumpolar Health, 2019
Waardenburg syndrome (WS) is an orphan genetic disease with autosomal dominant pattern of inheritance characterised by varying degrees of hearing loss accompanied by skin, hair and iris pigmentation abnormalities. Four types of WS differing in phenotypic
Nikolay A. Barashkov, Georgii P. Romanov, Uigulaana P. Borisova, Aisen V. Solovyev, Vera G. Pshennikova, Fedor M. Teryutin, Alexander A. Bondar, Igor V. Morozov, Elza K. Khusnutdinova, Olga L. Posukh, Tatiana E. Burtseva, Jon Øyvind Odland, Sardana A. Fedorova   +12 more
doaj   +1 more source

Pleurochrysis carterae Hot-Water Extract Inhibits Melanogenesis in Murine Melanoma Cells

Cosmetics, 2019
In this study, we examined the effect of a hot-water extract of coccolithophore Pleurochrysis carterae on melanogenesis in B16F1 and B16F10 melanoma cells. P.
Kazuomi Sato, Yuji Yamaguchi, Setsuko Sakaki, Hiroyuki Takenaka   +3 more
doaj   +1 more source

MITF-independent pro-survival role of BRG1-containing SWI/SNF complex in melanoma cells. [PDF]

PLoS ONE, 2013
Metastasized malignant melanoma has a poor prognosis because of its intrinsic resistance to chemotherapy and radiotherapy. The central role in the melanoma transcriptional network has the transcription factor MITF (microphthalmia-associated transcription
Lubica Ondrušová, Jiri Vachtenheim, Jiri Réda, Petra Záková, Kamila Benková   +4 more
doaj   +1 more source

Phyllanthus acidus (L.) Skeels and Rhinacanthus nasutus (L.) Kurz leaf extracts suppress melanogenesis in normal human epidermal melanocytes and reconstitutive skin culture

Asian Pacific Journal of Tropical Medicine, 2019
Objective: To determine the effect of extracts from Phyllanthus acidus (P. acidus) (L.) Skeels and Rhinacanthus nasutus (R. nasutus) (L.) Kurz leaves on melanogenesis and the underlying mechanism in normal human epidermal melanocytes (NHEM) and a ...
Moragot Chatatikun, Takeshi Yamauchi, Kenshi Yamasaki, Anchalee Chiabchalard, Setsuya Aiba   +4 more
doaj   +1 more source

Clinical, pathological and dermoscopic phenotype of MITF p.E318K carrier cutaneous melanoma patients

Journal of Translational Medicine, 2020
Background The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele. However, the impact of this variant on clinico-phenotypic, as well as on
Giulia Ciccarese, Bruna Dalmasso, William Bruno, Paola Queirolo, Lorenza Pastorino, Virginia Andreotti, Francesco Spagnolo, Enrica Tanda, Giovanni Ponti, Cesare Massone, Francesco Drago, Aurora Parodi, Giovanni Ghigliotti, Maria Antonietta Pizzichetta, Paola Ghiorzo, Italian Melanoma Intergroup (I.M.I.)   +15 more
doaj   +1 more source

Cochlear Melanocytes and MITF Signaling [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2001
Melanocytes occur not only in the skin and eyes but in the cochlea, where they exist as intermediate cells of the stria vascularis. Intermediate cells play an important role for cochlear function: Na+K+-ATPase and potassium channels of intermediate cells are essential for production of endocochlear potential and for preparation of ionic milieu in the ...
openaire   +2 more sources